Interventions to Improve Cognitive Functioning After Traumatic Brain Injury (TBI)

Chen, Anthony; Novakovic-Agopian, Tatjana; Loya, Fred

doi:10.1007/978-3-030-22436-3_17

Cited by 2 publications

(1 citation statement)

References 287 publications

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“…While neuro-stimulants are widely used to tease out their impact functional recovery [12][13][14], with few exceptions, there is a scarcity of studies shedding light on when is the most optimal time to commence initiation of neuro-stimulants. In the literature, the time elapsed since the injury is often reported to have been shown to range from a day to several years after initial TBI injury [21,22]. There is no description of whether the participants were treated with methylphenidate during an acute or chronic post-TBI phase.…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach

et al. 2020

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Background: Road traffic accidents are known to be the main cause of traumatic brain injury (TBI). TBI is also a leading cause of death and disability. This study, by means of the idiographic approach (single-case experimental designs using multiple-baseline designs), has examined whether methylphenidate (MPH-trade name Ritalin) had a differential effect on cognitive measures among patients with TBI with the sequel of acute and chronic postconcussion syndromes. The effect on gender was also explored. Methods: In comparison with healthy controls, patients with TBI (acute and chronic) and accompanying mild cognitive impairment (MCI) were screened for their integrity of executive functioning. Twenty-four patients exhibiting executive dysfunction (ED) were then instituted with the pharmacological intervention methylphenidate (MPH). The methylphenidate was administered using an uncontrolled, open label design. Results: The administration of methylphenidate impacted ED in the TBI group but had no effect on mood. Attenuation of ED was more apparent in the chronic phases of TBI. The effect on gender was not statistically significant with regard to the observed changes.

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