Injecting vasopressin intramyometrially reduces bleeding during myomectomy. It is challenging to the anesthesiologist in view of its side effects. Low concentrations of vasopressin has been considered to be safe, but sometimes it can lead to undesirable effects such as bradycardia with loss of peripheral pulse, non recordable blood pressure further leading to cardiac arrest. We report a case history of a patient who had developed bradycardia and dyspnea along with loss of peripheral pulse after local infiltration of 5 unit of vasopressin (20units diluted in 100ml NS), patient was revived by successful resuscitation.