Intervertebral disc as a source of pain

Rea, William J.; Kapur, Sandeep; Mutagi, Hirachand

doi:10.1093/bjaceaccp/mks028

Cited by 25 publications

(20 citation statements)

References 9 publications

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“…IVD degeneration is a cell-driven process that starts in the NP [6] . It results from a change in the physiochemical cellular environment that leads NP cells to produce catabolic and degradative enzymes causing progressive tissue degeneration, loss of disc height and ultimately pain [7] , [8] , [9] , [10] , [11] , [12] . Due to the avascular nature of the NP and the low mitotic activity of NP cells, the IVD has a low self-healing ability.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications

et al. 2019

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“…Degenerative Disc Disease (DDD), a common pathological condition that adversely affects approximately 1 in 7 individuals worldwide, is associated with severe neurological consequences and is a significant cause of radiating chronic lower back pain and paresthesia in the back and extremities (5–7). Up to 45% of cases of lower back pain with or without radiculopathy can be attributed to DDD (8). …”

Section: Introductionmentioning

confidence: 99%

Role of Sonic Hedgehog Signaling Pathway in Intervertebral Disk Formation and Maintenance

Rajesh

Dahia

2018

Curr Mol Bio Rep

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a) Purpose of Review: The intervertebral discs (IVD) are an essential component of the spine. Degeneration of the discs, commonly due to age or injury, is a leading cause of chronic lower back pain. Despite its high prevalence, there is no effective treatment for disc disease due to limited understanding of disc at the cellular and molecular level. b) Recent Findings: Recent research has demonstrated the importance of the intracellular developmental pathway sonic hedgehog (Shh) during the formation and postnatal maintenance of the IVD. Recent studies corroborate that the down-regulation of SHH expression is associated with pathological changes in the IVDs and demonstrate the reactivation of the hedgehog pathway as a promising avenue for rescuing health disc structure and function. c) Summary: Understanding the role of developmental signaling pathways that regulate disc formation and maintenance may help develop strategies to recapitulate the same mechanism for disc treatment and hence improve the quality and longevity of patient lives.

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“…Symptoms and clinical presentations associated with lumbar disc degeneration and lumbosacral nerve lesion are discogenic pain, radical pain, muscular weakness, and cutaneous innervation defect. Discogenic pain is caused by a damaged intrinsic intervertebral disc in the lumbar region [ 47 ]. As the disc begins to degenerate, the disc itself becomes painful and movements that place stress on the disc may result in discogenic pain that comes from the disc.…”

Section: Clinical Presentation Of Lumbar Disc Degeneration and Lummentioning

confidence: 99%

Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions

Liyew

2020

International Journal of Rheumatology

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Lumbar disc degeneration is defined as the wear and tear of lumbar intervertebral disc, and it is mainly occurring at L3-L4 and L4-S1 vertebrae. Lumbar disc degeneration may lead to disc bulging, osteophytes, loss of disc space, and compression and irritation of the adjacent nerve root. Clinical presentations associated with lumbar disc degeneration and lumbosacral nerve lesion are discogenic pain, radical pain, muscular weakness, and cutaneous. Discogenic pain is usually felt in the lumbar region, or sometimes, it may feel in the buttocks, down to the upper thighs, and it is typically presented with sudden forced flexion and/or rotational moment. Radical pain, muscular weakness, and sensory defects associated with lumbosacral nerve lesions are distributed on lower extremities, the buttock, lower abdomen, and groin region. A lumbosacral plexus lesion presents different symptoms in the territories of the lumbar and sacral nerves. Patients with lumbar plexus lesion clinically present with weakness of hip flexion, knee extension, thigh adduction, and sensory loss in the lower abdomen, inguinal region, and over the entire medial, lateral, and anterior surfaces of the thigh and the medial lower leg, while sacral plexus lesion presents clinical symptoms at nerve fibers destined for the sciatic nerve, common peroneal nerve, and pudendal nerve. Weakness of ankle inversion, plantar flexion, and foot drop are the main clinical manifestations of the sacral plexus lesion area. Numbness and decreased sensation are also present along the anterolateral calf and dorsum of the foot. On examination, foot eversion is usually stronger than foot dorsiflexion. The patients may also present with pain and difficulty of bowel movements, sexual dysfunction assessments, and loss of cutaneous sensation in the areas of the anal canal, anus, labia major, labia minor, clitoris, penis, and scrotum.

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Intervertebral disc as a source of pain

Cited by 25 publications

References 9 publications

Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications

Graphene oxide containing self-assembling peptide hybrid hydrogels as a potential 3D injectable cell delivery platform for intervertebral disc repair applications

Role of Sonic Hedgehog Signaling Pathway in Intervertebral Disk Formation and Maintenance

Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions

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