Intervertebral Disk Degeneration: T1ρ MR Imaging of Human and Animal Models

Zhou, Zhiyu; Jiang, Bo; Zhou, Zhiyang; Pan, Ximin; Sun, Haibo; Huang, Baoding; Tang, Liang; Ringgaard, Steffen; Zou, Xuenong

doi:10.1148/radiol.13120874

Cited by 32 publications

(35 citation statements)

References 28 publications

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“…In contrast to the above studies as well as the present results, Zhou et al did not find a significant influence of age on the T1ρ relaxation time [16]. They examined 80 patients with low back pain at 1.5 T. While there was a significant negative correlation between Pfirrmann grade and T1ρ relaxation time, age was not found to have a significant influence on T1ρ times.…”

contrasting

confidence: 99%

“…This is justified, however, as the described preliminary test showed a very low level of interobserver variability. In addition, studies in the literature have shown excellent reproducibility results and high levels of interobserver reliability [6,16,30]. It would not have been possible to control for the minimal bias in light of the fact that none of the included individuals had ever suffered from low back pain, even though each individual was examined and interviewed by an orthopedic spine surgeon.…”

Section: Limitationsmentioning

confidence: 99%

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Influence of Age, BMI, Gender and Lumbar Level on T1ρ Magnetic Resonance Imaging of Lumbar Discs in Healthy Asymptomatic Adults

Gübitz

Lange

Gosheger

et al. 2017

Fortschr Röntgenstr

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40/18 18 81 18 11 r.guebitz@asklepios.com ZUSAMMENFASSUNG Ziel Ermittlung der Größenordnung der T1ρ Werte der lumbalen Bandscheiben in gesunden asymptomatischen Probanden bei 1,5 T. Zusätzlich wurde der Einfluss von Alter, body mass index (BMI), Geschlecht und lumbaler Level auf die T1ρ Relaxation. Material und MethodenIn der prospektiven Studie wurden 81 freiwillige Probanden zwischen 20 und 80 Jahren eingeschlossen und in drei Altersgruppen unterteilt (A, 20 -39 Jahre; B, 40 -59 Jahre; C, 60 -80 Jahre). Alle Probanden wurden in einem 1,5 T MRT untersucht und sagittale T1ρ Bilder akquiriert. Die ermittelten T1ρ Relaxationszeiten wurden korreliert mit Alter, BMI, Geschlecht und lumbalem Level jeweils bezogen auf die gesamte Bandscheibe, den Annulus fibrosus und den Nucleus pulposus.Ergebnisse Das Alter zeigte einen signifikanten Einfluss auf die T1ρ Relaxationszeit in allen lumbalen Leveln wobei zunehmendes Alter mit abnehmenden Relaxationszeiten verbunden war. Darüber hinaus zeigte sich ein signifikanter Unterschied zwischen den Altersgruppen A vs. C und B vs. C (P = 0,0008 und P = 0,0149). Kein signifkanter Unterschied bestand zwischen den T1ρ Relaxationszeiten von Männern und Frauen (P > 0,05). Der BMI zeigte eine signifikant negative Korrelation mit der T1ρ Relaxationszeit (P < 0,0001). Hinsichtlich des lumbalen Levels zeigte sich eine signifikante Abnahme der Relaxationszeiten von L 1/2 zu L5 / S1 (P = 0,0013).Schlussfolgerung Steigendes Alter korrelierte signifikant mit zunehmender Degeneration lumbaler Bandscheiben bei asymptomatischen Probanden, insbesondere ab einem Alter von 60 Jahren. Ein hoher BMI korrelierte ebenfalls signifikant mit zunehmender Degeneration. Die unteren lumbalen Bandscheiben zeigten insgesamt eine fortgeschrittenere Degeneration als die oberen. Kernaussagen ▪ Steigendes Alter vermindert die T1ρ Relaxationszeit derBandscheiben signifikant (P < 0,05) ▪ Geschlecht zeigt keinen signifikanten Einfluss auf die T1ρRelaxationszeit (P > 0,05) ▪ BMI korreliert signifikant negativ mit der T1ρ Relaxationszeit (P < 0,01). ▪ Signifikant niedrigere Relaxationszeiten der unteren gegenüber oberen LWS (P < 0,01). This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. ABSTR AC T PurposeTo assess the T1ρ range of lumbar intervertebral discs in healthy asymptomatic individuals at 1.5 T and to investigate the influence of age, body mass index (BMI), gender, and lumbar level on T1ρ relaxation. Materials and MethodsIn a prospective study, a total of 81 volunteers aged 20 -80 years were included in this study and divided into three age groups (A: 20 -39y; B: 40 -59y; C: 60 -80y). All of the volunteers underwent magnetic resonance imaging (MRI) at 1.5 T with acquisition of sagittal T1ρ images. The calculated T1ρ relaxation times were correlated with age, BMI, gender, and lumbar level relative to the total disc, the annulus fibrosus, and the nucleus pulposus.Results Age had a significant influence on T1ρ relaxation times at all lumbar levels, with increasing age...

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contrasting

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Influence of Age, BMI, Gender and Lumbar Level on T1ρ Magnetic Resonance Imaging of Lumbar Discs in Healthy Asymptomatic Adults

Gübitz

Lange

Gosheger

et al. 2017

Fortschr Röntgenstr

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“…The discs were graded on the basis of the sagittal T2-weighted MR images, which provide MR-based semi-quantitative evaluations of the discs. The discs were assigned into one of the two groups based on the grading — non-degenerated (Pfirrmann grades 1, 2) or degenerated (Pfirrmann grades 3, 4) disc groups, in order to evaluate the significance of the differences between the normal/early and later stages of disc degeneration in terms of the T1ρ and T2 measurements (1415). …”

Section: Methodsmentioning

confidence: 99%

Interobserver and Test-Retest Reproducibility of T1ρ and T2 Measurements of Lumbar Intervertebral Discs by 3T Magnetic Resonance Imaging

et al. 2016

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ObjectiveTo investigate the interobserver and test-retest reproducibility of T1ρ and T2 measurements of lumbar intervertebral discs using 3T magnetic resonance imaging (MRI).Materials and MethodsThis study included a total of 51 volunteers (female, 26; male, 25; mean age, 54 ± 16.3 years) who underwent lumbar spine MRI with a 3.0 T scanner. Amongst these subjects, 40 underwent repeat T1ρ and T2 measurement acquisitions with identical image protocol. Two observers independently performed the region of interest measurements in the nuclei pulposi of the discs from L1–2 through L5–S1 levels. Statistical analysis was performed using intraclass correlation coefficient (ICC) with a two-way random model of absolute agreement. Comparison of the ICC values was done after acquisition of ICC values using Z test. Statistical significance was defined as p value < 0.05.ResultsThe ICCs of interobserver reproducibility were 0.951 and 0.672 for T1ρ and T2 mapping, respectively. The ICCs of test-retest reproducibility (40 subjects) for T1ρ and T2 measurements were 0.922 and 0.617 for observer A and 0.914 and 0.628 for observer B, respectively. In the comparison of the aforementioned ICCs, ICCs of interobserver and test-retest reproducibility for T1ρ mapping were significantly higher than T2 mapping (p < 0.001).ConclusionThe interobserver and test-retest reproducibility of T1ρ mapping were significantly higher than those of T2 mapping for the quantitative assessment of nuclei pulposi of lumbar intervertebral discs.

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“…Degeneration changes in the IVD are characterized by a loss of hydrated proteoglycan-rich matrix of the nucleus pulposus (NP) and collagen, both of which affect the mechanics of the IVD[3]. In facet joint (FJ) osteoarthritis, patients demonstrate a loss of articular cartilage matrix, morphological reconstruction of the subchondral bone, and local tissue inflammation[2, 4, 5].…”

Section: Introductionmentioning

confidence: 99%

“…Decreased GAG content may lead to an increased mobile proton density in bulk water and an increased in T1ρ relaxation times. Therefore, T1ρ mapping could be a reliable method for quantitatively assessing PG content in IVDs and cartilage without the need for a contrast agent[3, 19–21]. …”

Section: Introductionmentioning

confidence: 99%

Correlation study between facet joint cartilage and intervertebral discs in early lumbar vertebral degeneration using T2, T2* and T1ρ mapping

Zhang

Duan

et al. 2017

PLoS ONE

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Recent advancements in magnetic resonance imaging have allowed for the early detection of biochemical changes in intervertebral discs and articular cartilage. Here, we assessed the feasibility of axial T2, T2* and T1ρ mapping of the lumbar facet joints (LFJs) to determine correlations between cartilage and intervertebral discs (IVDs) in early lumbar vertebral degeneration. We recruited 22 volunteers and examined 202 LFJs and 101 IVDs with morphological (sagittal and axial FSE T2-weighted imaging) and axial biochemical (T2, T2* and T1ρ mapping) sequences using a 3.0T MRI scanner. IVDs were graded using the Pfirrmann system. Mapping values of LFJs were recorded according to the degeneration grades of IVDs at the same level. The feasibility of T2, T2* and T1ρ in IVDs and LFJs were analyzed by comparing these mapping values across subjects with different rates of degeneration using Kruskal-Wallis tests. A Pearson’s correlation analysis was used to compare T2, T2* and T1ρ values of discs and LFJs. We found excellent reproducibility in the T2, T2* and T1ρ values for the nucleus pulposus (NP), anterior and posterior annulus fibrosus (PAF), and LFJ cartilage (intraclass correlation coefficients 0.806–0.955). T2, T2* and T1ρ mapping (all P<0.01) had good Pfirrmann grade performances in the NP with IVD degeneration. LFJ T2* values were significantly different between grades I and IV (PL = 0.032, PR = 0.026), as were T1ρ values between grades II and III (PL = 0.002, PR = 0.006) and grades III and IV (PL = 0.006, PR = 0.001). Correlations were moderately negative for T1ρ values between LFJ cartilage and NP (rL = −0.574, rR = −0.551), and between LFJ cartilage and PAF (rL = −0.551, rR = −0.499). T1ρ values of LFJ cartilage was weakly correlated with T2 (r = 0.007) and T2* (r = −0.158) values. Overall, we show that axial T1ρ effectively assesses early LFJ cartilage degeneration. Using T1ρ analysis, we propose a link between LFJ degeneration and IVD NP or PAF changes.

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Intervertebral Disk Degeneration: T1ρ MR Imaging of Human and Animal Models

Abstract: The data demonstrate that rapid intervertebral disk degeneration occurs early in the degenerative cascade, between Pfirrmann grades II and III.

Cited by 32 publications

References 28 publications

Influence of Age, BMI, Gender and Lumbar Level on T1ρ Magnetic Resonance Imaging of Lumbar Discs in Healthy Asymptomatic Adults

Influence of Age, BMI, Gender and Lumbar Level on T1ρ Magnetic Resonance Imaging of Lumbar Discs in Healthy Asymptomatic Adults

Interobserver and Test-Retest Reproducibility of T1ρ and T2 Measurements of Lumbar Intervertebral Discs by 3T Magnetic Resonance Imaging

Correlation study between facet joint cartilage and intervertebral discs in early lumbar vertebral degeneration using T2, T2* and T1ρ mapping

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