Intestinal Absorption and the Activity of Enzymatic Hydrolysis of Ascorbyl-2-Phosphate in Rainbow Trout.

泰幸, 宮崎; 守, 佐藤; 〓二, 吉中; 守彦, 坂口

doi:10.2331/suisan.59.2059

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…The bioavailability and biopotency of the various salts of ascorbyl-2-polyphosphate and ascorbyl-2-monphosphate have been evaluated in different fishes. In the intestine of rainbow trout, Atlantic salmon, channel catfish, sea bass, gilthead seabream, eel, hybrid sturgeon Acipenser ruthenus X A. bueri and European catfish Silurus glundis, ascorbyl-2-mono-and polyphosphate is converted to ascorbate and absorbed (Sandnes and Waagbo 1991;Miyasaki et al 1992Miyasaki et al , 1993Buddington et al 1993;Dabrowski et al 1994;Papp et al 1995;Amerio et al 1998). Ascorbic acid is absorbed by a saturable, Na-dependent transporter (Rose and Choi 1990;Maffia et al 1993) and passive diffusion is likely to occur at higher ascorbic acid intakes.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of Ascorbyl‐2‐Monophosphate to Channel Catfish Fed Purified and Practical Diets

Sealey

Gaylord

Gatlin

et al. 2002

J World Aquaculture Soc

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Section: Discussionmentioning

confidence: 99%

Bioavailability of Ascorbyl‐2‐Monophosphate to Channel Catfish Fed Purified and Practical Diets

Sealey

Gaylord

Gatlin

et al. 2002

J World Aquaculture Soc

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“…In contrast, many data are available for fish. In vitro data obtained by Miyasaki et al (1993) with ligated intestinal segments and a comprehensive review of Dabrowski et al (1994) suggest that (i) ascorbyl phosphate is protected against oxidation in the intestinal lumen, (ii) it is at least partially hydrolysed in the intestine and, therefore, (iii) absorbed as ascorbic acid and as ascorbyl phosphate, which is hydrolysed in tissues. In summary, tissue deposition of ascorbic acid in fish is more efficient after the administration of ascorbyl phosphate than of ascorbic acid.…”

Section: Absorption Distribution Metabolism and Excretion (Adme)mentioning

confidence: 99%

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid and sodium calcium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG

2013

EFS2

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Vitamin C (formerly known as antiscorbutic vitamin) is essential for primates, guinea pigs and fish. Vitamin C, in the form of ascorbic acid and sodium calcium ascorbyl phosphate, is safe for all animal species. Setting a maximum content in feed and water for drinking is not considered necessary. Data on the vitamin C consumption of consumers are based on the levels of vitamin C in foodstuffs, including food of animal origin, produced in accordance with current EU legislation on the supplementation of feed with vitamin C. The exposure is far below the guidance level. Any potential contribution of the use of vitamin C in feed is therefore already considered in the above data. Consequently, the use of vitamin C in animal nutrition is not of concern for consumer safety. In the absence of inhalation toxicity studies it would be prudent to assume that inhalation of dust from the additives presents a health hazard to workers and measures should be taken to minimise inhalation exposure. In the absence of data, ascorbic acid and sodium calcium ascorbyl phosphate should be considered as irritant to skin and eyes and as dermal sensitisers. The supplementation of feed with vitamin C does not pose a risk to the environment. Ascorbic acid and sodium calcium ascorbyl phosphate are regarded as effective sources of vitamin C when added to feed or water for drinking

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“…In contrast, many data are available for fish. In vitro data obtained by Miyasaki et al (1993) in ligated intestinal segments and a comprehensive review by Dabrowski et al (1994) suggest that (i) ascorbyl phosphate is protected against oxidation in the intestinal lumen, (ii) it is at least partially hydrolysed in the intestine and, therefore, (iii) absorbed as ascorbic acid and as ascorbyl phosphate, which is hydrolysed in tissues. In summary, tissue deposition of ascorbic acid in fish is more efficient after the administration of ascorbyl phosphate than of ascorbic acid.…”

Section: Absorption Distribution Metabolism and Excretion (Adme)mentioning

confidence: 99%

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd

2013

EFS2

View full text Add to dashboard Cite

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd. EFSA Journal 2013;11(2) European Food Safety Authority (EFSA), Parma, Italy ABSTRACTVitamin C is essential for primates, guinea pigs and fish. Vitamin C, in the form of ascorbic acid and its calcium and sodium salts, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate, is safe for all animal species. Setting a maximum content in feed and water for drinking is not considered necessary. Data on the vitamin C consumption of consumers are based on the levels of vitamin C in foodstuffs, including food of animal origin, produced in accordance with current EU legislation on the supplementation of feed with vitamin C. The exposure is far below the guidance level. Any potential contribution of the use of vitamin C in feed is therefore already considered in the above data. Consequently, the use of vitamin C in animal nutrition is not of concern for consumer safety. In the absence of inhalation toxicity studies it would be prudent to assume that inhalation of dust from the additives presents a health hazard to workers. Sodium calcium ascorbyl phosphate is not an irritant to skin and eyes and is unlikely to be a skin sensitiser. This conclusion is extrapolated to sodium ascorbyl phosphate. In the absence of data, ascorbic acid, sodium ascorbate, calcium ascorbate and ascorbyl palmitate should be considered as irritant to skin and eyes and as dermal sensitisers. The supplementation of feed with vitamin C does not pose a risk to the environment. Ascorbic acid, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate are regarded as effective sources of vitamin C when added to feed or water for drinking. Since ascorbic acid, sodium ascorbate, calcium ascorbate and ascorbyl palmitate are authorised for use as antioxidants in food and their function in feed is essentially the same as that in food, no further demonstration of efficacy is considered necessary.

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Intestinal Absorption and the Activity of Enzymatic Hydrolysis of Ascorbyl-2-Phosphate in Rainbow Trout.

Cited by 6 publications

References 15 publications

Bioavailability of Ascorbyl‐2‐Monophosphate to Channel Catfish Fed Purified and Practical Diets

Bioavailability of Ascorbyl‐2‐Monophosphate to Channel Catfish Fed Purified and Practical Diets

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid and sodium calcium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd

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