Intestinal Absorption of Inorganic Mercury in Rat

Piotrowski, J. K.; Szymańska, Joanna; Skrzypińska-Gawrysiak, Małgorzata; Kotelo, Jolanta; Sporny, Stanisław

doi:10.1111/j.1600-0773.1992.tb00426.x

Cited by 17 publications

(9 citation statements)

References 12 publications

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“…After ingestion, a slight amount of methylmercury is converted by intestine germs to inorganic form (Nakamura et al, 1977;Rowland et al, 1980) which is not as well bioavailable as the organic form (Clarkson, 1971;Kostial et al, 1978;Piotrowski et al, 1992;) and the majority of methylmercury is distributed ubiquitously in all tissues Data are mean ± SD. NS, not significant.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury

et al. 2010

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All forms of mercury are considered poisonous. Methylmercury, one organic form, is highly toxic to many organs. The aim of the present study was to assess the effects of this form on the reproductive system in the rat. For this, 20 male rats were divided into two groups. One, which is considered as reference, received tap water. The second group received tap water containing methylmercury at the rate of 20 mg l⁻¹ for 8 weeks. At the end of the experiment, blood samples were collected for the determination of total mercury and plasma testosterone. The left testes were used for the determination of total mercury and histological examination. Appropriate centrifugation was applied on right testes to extract interstitial and seminiferous tubular fluids. The epididymides were homogenised for the sperm count. Our results showed a dramatic fall in the plasma testosterone in the contaminated animals. The fall in plasmatic testosterone seems to be in relation with the decrease in the secretion of testosterone. In association with this, the concentration of testosterone in seminiferous tubules fluid dropped about 55% in the poisoned animals in comparison with the controls. Despite this, no decrease in the epididymal sperm count in contaminated rats was observed.

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Section: Discussionmentioning

confidence: 99%

Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury

et al. 2010

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“…Published values for the absolute bioavailability of mercuric chloride in adult animals range from 1-25% (Kostial et al, 1978;Piotrowski et al, 1992;Nielsen and Andersen, 1990). If more reports of the bioavailability of other forms of mercury become available, they too are likely to vary.…”

Section: Better Characterization Of the Variation In Absolute Bioavaimentioning

confidence: 97%

ATSDR Science Panel on the Bioavailability of Mercury in Soils: Lessons Learned

1997

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On the basis of discussion and analysis during and following an ATSDR science panel on the bioavailability of mercury in soils, it is apparent that the default assumption of 100% relative bioavailability for mercury-contaminated soils is excessively conservative. However, current knowledge does not allow the development of default assumptions or guidelines for determining relative bioavailability of mercury in soils. Until such default assumptions or guidelines can be developed, site-specific assays of bioavailability, preferably using either animal bioassays or validated in vitro techniques, may provide the best approach for estimating soil-mercury bioavailability.

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“…@ and at higher doses compared to low doses. (32) In adult mice, "true absorption" of mercuric chloride (determined by comparing the whole-body retention at 3-14 days following oral vs. intraperitoneal administration of a single dose) was estimated to be 20-25% (range 17-30%). '24)…”

Section: In Vivo Estimates Of the Bioavailability Of Inorganic Mercurmentioning

confidence: 99%

Current Views on the Oral Bioavailability of Inorganic Mercury in Soil: Implications for Health Risk Assessments

1997

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Due to the presence of mercury at a number of major contaminated sites in the United States, the bioavailability of inorganic mercury in soil following ingestion has emerged as an important public health issue. Studies of the leachability/solubility of inorganic mercury in soil have shown that it is largely immobile, thereby suggesting that it will not be readily available for absorption in the gastrointestinal tract. Ignoring the effect of the soil matrix on decreasing bioavailability may result in a substantial overprediction of risks due to ingestion of contaminated soil. This paper discusses current knowledge about the oral bioavailability of inorganic mercury in soil and offers suggestions about how these data may be applied in human health risk assessment. Though precise estimates are not available, in vivo and in vitro estimates of the bioavailability of different inorganic mercury species in different matrices suggest that the bioavailability of mercury in soil is likely to be significantly less, on the order of at least three- to tenfold, than the bioavailability of mercuric chloride, the species used to derive the toxicity criteria for inorganic mercury. Because bioavailability can vary significantly with soil type, soil aging, the presence of co-contaminants and other factors, it is suggested that whenever the fiscal aspects justify a more precise estimate of bioavailability, site-specific estimates be developed. To develop a database for identifying a less expensive and more efficient method for estimating bioavailability, it is suggested that in vivo studies be conducted concurrently with in vitro studies. However, due to the lack of precision associated with the derivation of the most widely-used health guidance value for inorganic mercury (the USEPA RfD), additional work to address the uncertainties in the RfD is recommended.

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Intestinal Absorption of Inorganic Mercury in Rat

Cited by 17 publications

References 12 publications

Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury

Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury

ATSDR Science Panel on the Bioavailability of Mercury in Soils: Lessons Learned

Current Views on the Oral Bioavailability of Inorganic Mercury in Soil: Implications for Health Risk Assessments

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