Intestinal Absorption of Sugars

Crane, Robert K.

doi:10.1152/physrev.1960.40.4.789

Cited by 612 publications

(198 citation statements)

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“…A low concentration of phlorizin, a characteristic inhibitor of sugar absorption in the adult intestine (Crane, 1968), was also found to inhibit significantly sugar accumulation by jejunal rings of neonatal intestine (Table 1). Thus the inhibition of sugar absorption in vitro is similar in developing and mature intestine (Sanford, 1967).…”

Section: Resultsmentioning

confidence: 93%

Sugar absorption by foetal and neonatal rat intestine in vitro.

Bamford¹,

Ingham²

1975

The Journal of Physiology

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1. Sugar absorption by foetal and neonatal rat intestine has been examined using an in vitro accumulation technique. 2. The capacity for active sugar absorption is present in the rat intestine by the 17th day of gestation. Considerable variation in uptake occurs during the first month post partum; the greatest uptake place during the first week. 3. The absorption of sugars by the developing gut resembles in several respects that by the mature intestine. However, the adult pattern of functional localization along the intestine is not fully established until after the 3rd week post partum. 4. Kinetic studies indicate that variations with age in the distribution of sugar ‘carriers’ along the intestine, rather than changes in the ‘carriers’ themselves, account for the observed variations in absorption.

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Section: Resultsmentioning

confidence: 93%

Sugar absorption by foetal and neonatal rat intestine in vitro.

Bamford¹,

Ingham²

1975

The Journal of Physiology

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“…In the present work, however, the structural requirements of sugars for antagonism of the dextran response do not correspond with those of any known transport system. The systems investigated include the penetration of sugars into muscle cells (Battaglia & Randle, 1959 and human erythrocytes (LeFevre & Marshall, 1958), and active transport in the intestine (Cori, 1925;Crane, 1960;Rosenberg, 1961;Wilbrandt & Rosenberg, 1961). Some of the sugars which increase the potential or support fluid transfer across the intestinal wall (Barry, Dikstein, Matthews, Smyth & Wright, 1964) also differ from those which are potent antagonists of the dextran response.…”

Section: Discussionmentioning

confidence: 99%

Structural Requirements of Sugars as Antagonists of the Vascular Response to Dextran in Rat Skin

Poyser

West

1968

British Journal of Pharmacology and Chemotherapy

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The increase in vascular permeability induced by dextran in rat skin is inhibited by the simultaneous intradermal administration of glucose and certain other sugars (Beraldo, Dias Da Silva & Lemos Fernandes, 1962). These sugars also prevent the local vascular changes produced by other polysaccharides (Poyser & West, 1965;Harris, Luscombe & Poyser, 1967) and inhibit the release of histamine in vitro by dextran from tissue mast cells (Goth, 1961;Beraldo et al., 1962;Dias Da Silva & Lemos Fernandes, 1965). In the present paper, an attempt has been made to determine the structural and stereospecific requirements of sugars for activity as antagonists of the dextran response. The mechanism of inhibition by these carbohydrates has also been investigated. METHODSInhibition by sugars and other agents of the vascular response to dextran in rat skin was studied using the method of Poyser & West (1965). Each antagonist was dissolved in dextran (1 mg/ml.) and injected intradermally, in volumes of 0.1 ml., into the shaved ventral abdominal skin of male hooded Lister rats (body weight about 200 g). Each rat received eight to ten intradermal injections immediately after the intravenous injection of azovan blue dye (7 mg/kg). Thirty minutes later the rats were killed, and the reaction to each injection was assessed by measuring the mean diameter of the blue area on the inner surface of the skin. The response given by dextran (100 jug) in the presence of each sugar or other agent was then expressed as a percentage of that found in its absence. From the log dose/inhibition curves, doses producing 50% inhibition (termed the ID50 values) were obtained. Each value shown in the tables is the mean and standard error of three experiments, each using at least three rats.

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“…Often, the alkaline phosphatase is found to be located in the microvilli of cells which deal with absorption of nutrients (Moog 1962, Hitanen 1973. Crane (1960) proposes that the alkaline phosphatase is involved in sugar absorption, while Przelecka et al (1962) and Dominas et al (1963) mention increased activity of the enzyme in vertebrate intestine after a lipid rich diet. Ono (1974), on the other hand, did not observe differences in alkaline phosphatase ac tivity in rat small intestine when different diets (protein or lipid) are applied and he proposed that the enzyme participates in the absorption of both kinds of nu trients.…”

Section: B Acid Phosphatasementioning

confidence: 99%