Intestinal archaea inversely associated with childhood asthma

Barnett, David J.M.; Mommers, Monique; Penders, John; Arts, Ilja C. W.; Thijs, Carel

doi:10.1016/j.jaci.2019.02.009

Cited by 23 publications

(19 citation statements)

References 9 publications

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“…The presence of M. stadtmanae in stool samples from 6-to 10-year-old children has been associated in a dose-dependent manner with a reduced risk of being diagnosed with asthma (Barnett et al, 2019). This effect was independent of parental asthma status (Barnett et al, 2019). Only 8.3% of samples tested in this study were positive for M. stadtmanae, however, and certain archaeal proteins have actually been proposed to have pro-inflammatory (Blais Lecours et al, 2011) or allergenic properties (Bragin et al, 2018).…”

Section: Archaea-emerging Players In Human Gutmentioning

confidence: 49%

“…A role for intestinal archaea in the dysbiosis-asthma paradigm was recently suggested by a study in a subset of 472 children from the KOALA birth cohort in the Netherlands (Barnett et al, 2019). The presence of M. stadtmanae in stool samples from 6-to 10-year-old children has been associated in a dose-dependent manner with a reduced risk of being diagnosed with asthma (Barnett et al, 2019).…”

Section: Archaea-emerging Players In Human Gutmentioning

confidence: 98%

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The Role of Lung and Gut Microbiota in the Pathology of Asthma

et al. 2020

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Section: Archaea-emerging Players In Human Gutmentioning

confidence: 49%

Section: Archaea-emerging Players In Human Gutmentioning

confidence: 98%

The Role of Lung and Gut Microbiota in the Pathology of Asthma

et al. 2020

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“…Moreover, increased abundance of M. stadtmanae was found to frequently correlate with disease and inflammation, in particular in inflammatory bowel disease 118,131 . In combination with its observed high pro-inflammatory potential, activation of the inflammasome, as well as strong B-cell and T-cell responses within the draining lymph nodes due to M. stadtmanae entering the bloodstream 18,115,132 , suggest a potential involvement in the development and or manifestation of disease. By contrast, a recent publication showed an association between M. stadtmanae carriage and a lower risk of asthma in young children, which is indicative for a beneficial role for M. stadtmanae 132 .…”

Section: Archaea In Human Health and Diseasementioning

confidence: 99%

The host-associated archaeome

et al. 2020

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Host-associated microbial communities have an important role in shaping the health and fitness of plants and animals. Most studies have focused on the bacterial, fungal or viral community, but have often neglected the archaeal component. The archaeal community, the so-called archaeome, is now growingly recognized as an important component of host-associated microbiomes. It is composed of various lineages, including mainly Methanobacteriales and Methanomassiliicoccales (Euryarchaeota), as well as representatives of the Thaumarchaeota. Host-archaeome interactions were mostly delineated from methanogenic archaea in the gastrointestinal tracts, where they contribute to substantial methane production, and are potentially also involved in disease-relevant processes. In this Review, we discuss the diversity and potential role of archaea associated with protists, plants and animals. We also present our current understanding of the archaeome in humans, the specific adaptations involved in interaction with the resident community as well as the host, and its role in health and disease.

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“…Until recently, bacterial members of a microbiome have been the primary focus of studies for reasons that include better established tools (molecular, analytic and reference knowledge base) to profile and understand bacterial ecology. However, there is increasing interest in non-bacterial members of the microbiota and their potential role in asthma pathogenesis [30][31][32] . For example, a recent study 30 of bronchoalveolar lavage (BAL) and endobronchial brush (EB) samples showed significant differences in the fungal microbiota of asthmatic subjects with type 2-high versus type 2-low asthma phenotype irrespective of inhaled corticosteroid use which did not differ between the two subgroups.…”

Section: Asthma and Associated Microbiome Features Across Mucosal Compartmentsmentioning

confidence: 99%

Ecological interactions in asthma: from environment to microbiota and immune responses

Kozik

Huang²

2020

Current Opinion in Pulmonary Medicine

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Purpose of Review-Asthma is a heterogeneous condition shaped not only by genetics but also host conditioning by environmental factors. Recognizing the ecological context of microbeimmune interactions across environments and body sites is a necessary step towards better understanding how human microbiota influence or drive the pathogenesis and pathophysiology of asthma in its various presentations.Recent Findings-There is increasing evidence of a critical role for microbiota in asthma pathogenesis and outcomes across various body compartments, including the upper and lower airways and gut. We discuss recent studies from this area including: 1) development of a method to quantify microbial farm-effect in non-farm environments, 2) relationships between environmental microbial exposures and asthma prevalence across different geographies, 3) microbiome-mediated responses to ozone, and 4) microbiome-immune interactions within and across body compartments. Beyond bacteria, recent reports of asthma-associated differences in archaea and fungal organisms also are highlighted.Summary-Collective evidence warrants application of an ecological framework to advance mechanistic insights into microbiota-immune interactions in asthma. This is necessary to achieve goals of developing successful therapeutic interventions targeting modification of microbiomes.

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Intestinal archaea inversely associated with childhood asthma

Cited by 23 publications

References 9 publications

The Role of Lung and Gut Microbiota in the Pathology of Asthma

The Role of Lung and Gut Microbiota in the Pathology of Asthma

The host-associated archaeome

Ecological interactions in asthma: from environment to microbiota and immune responses

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