Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

Piperni, Elisa; Nguyen, Long H.; Manghi, Paolo; Kim, Hanseul; Pasolli, Edoardo; Andreu-Sánchez, Sergio; Arrè, Alberto; Bermingham, Kate M.; Blanco-Míguez, Aitor; Manara, Serena; Valles-Colomer, Mireia; Bakker, Elco; Busonero, Fabio; Davies, Richard; Fiorillo, Edoardo; Giordano, Francesca; Hadjigeorgiou, George; Leeming, Emily R.; Lobina, Monia; Masala, Marco; Maschio, Andrea; McIver, Lauren J.; Pala, Mauro; Pitzalis, Maristella; Wolf, Jonathan; Fu, Jingyuan; Zhernakova, Alexandra; Cacciò, Simone M.; Cucca, Francesco; Berry, Sarah E.; Ercolini, Danilo; Chan, Andrew T.; Huttenhower, Curtis; Spector, Tim D.; Segata, Nicola; Asnicar, Francesco

doi:10.1016/j.cell.2024.06.018

Cited by 9 publications

(1 citation statement)

References 118 publications

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“…Epidemiological studies and phylogenetic analysis of the small subunit ribosomal RNA (SSU rRNA) gene have revealed over 44 different subtypes, twelve of which STs 1-9, 12, 16, 23 have been identified in human stool samples [5], [6], [7], [8], [9]. Blastocystis was initially designated as a parasite and linked with IBS and other gastrointestinal disorders [10], [11]; however, more recent studies have indicated a negative correlation between the presence of the organism and gastrointestinal symptoms [8], [9], [12], [13], () muddling its association with disease. Blastocystis' genetic diversity further complicates interpretations, with many studies finding no relationship between inter and intra-subtype diversity and disease [9], [12].…”

Section: Introductionmentioning

confidence: 99%

The impact of antibiotics on the presence of the protozoan anaerobeBlastocystisand the surrounding microbiome: a case study

Newton,

Edwards,

Thompson

et al. 2024

Preprint

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Background: Blastocystis, the most prevalent eukaryotic gut microbe in humans, has a global distribution. Studies have linked its presence with distinct gut microbiome and metabolome profiles compared to those where the organism is absent. However, the in vivo effect of antibiotics on Blastocystis and the surrounding gut microbiome remains understudied. This case study aimed to explore how antibiotic consumption influences the presence of Blastocystis and the subsequent changes in the gut microbiome and metabolome of an individual with irritable bowel syndrome (IBS). Methods: Stool samples from an IBS patient, collected at various time points, were tested for Blastocystis presence using RT-PCR targeting the SSUrRNA gene, followed by sequencing of positive samples. Illumina sequencing determined the gut microbiome composition, while one-dimensional proton NMR spectroscopy analysed the metabolome composition. Statistical analyses were conducted to identify relationships between antibiotic consumption, bacterial diversity, metabolome composition, and Blastocystis presence. Results: Antibiotics significantly impacted the gut microbiome, with diversity declining early in the antibiotic course, then recovering later and post-course. Blastocystis was detected early, late, and post-course but not mid-course, coinciding with the decline in bacterial diversity. No significant differences were observed between Blastocystis-positive and Blastocystis-negative samples. However, bacterial composition significantly differed between samples collected before, early, and after the antibiotic course compared to those collected mid-course. Metabolite groups, including short-chain fatty acids, amino acids, and succinate, exhibited changes throughout the antibiotic course, indicating that gut metabolite composition is affected by antibiotic consumption. Discussion/Conclusion: While antibiotics did not significantly impact Blastocystis colonisation, they did cause a mid-course decline in microbial diversity and Blastocystis presence. The study also revealed significant alterations in important metabolites such as SCFAs and amino acids throughout the antibiotic course, with an altered metabolome observed post-course. This case study underscores the complex interactions between antibiotics, gut microbiota, and metabolites, highlighting the resilience of Blastocystis in the gut ecosystem.

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Section: Introductionmentioning

confidence: 99%

The impact of antibiotics on the presence of the protozoan anaerobeBlastocystisand the surrounding microbiome: a case study

Newton,

Edwards,

Thompson

et al. 2024

Preprint

View full text Add to dashboard Cite

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When the microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social sustainability

Zhou,

Xu,

Zhang

et al. 2024

iMetaOmics

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The convergence of microbiome science with the One Health principle heralds a transformative era in biology, prioritizing the collective well‐being of humans, animals, and the environment. This review delves into the intricate dance between microbiomes and their hosts, revealing their profound impact on health, nutrient cycles, and climate change. Championing a unified approach to health issues across diverse kingdoms of life, One Health emerges as a holistic strategy, underscored by a proposed universal balance theory, “Balance of Dynamic Factors.” This theory spotlights the equilibrium within microbial and human‐animal‐environment interactions, offering a revolutionary pathway to global health and social well‐being. It paves the way for disease prevention, health equity, and sustainability, all of which are purviews of a balanced ecological system. We navigate the challenges and opportunities of this integrative approach, culminating in a call for action for the incorporation of microbiome science into health policies, precision medicine, legislation, eco‐health projects, and education, thereby setting the stage for harmonious coexistence with our planet.

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Accelerating the paradigm shift in Blastocystis research

Tomiak,

Stensvold

2024

Trends in Parasitology

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Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

Cited by 9 publications

References 118 publications

The impact of antibiotics on the presence of the protozoan anaerobeBlastocystisand the surrounding microbiome: a case study

The impact of antibiotics on the presence of the protozoan anaerobeBlastocystisand the surrounding microbiome: a case study

When the microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social sustainability

Accelerating the paradigm shift in Blastocystis research

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