Intestinal blockage by carcinoma and Blastocystis hominis infection.

Horiki, Noriyuki; Kaneda, Yoshimasa; Maruyama, Masataka; Fujita, Yoshiyuki; Tachibana, Hiroshi

doi:10.4269/ajtmh.1999.60.400

Cited by 28 publications

(11 citation statements)

References 15 publications

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“…The infections in these 4 patients resolved spontaneously following surgery for the abdominal tumors. 9 The present case highlights the unusual identification of extraintestinal forms of B hominis in the abdominal fluid, confirming the clinical suspicion of intestinal perforation in this patient. To the best of our knowledge this is the first report of cytologic identification of this organism in a sample from peritoneal fluid.…”

Section: Discussionsupporting

confidence: 82%

Cytologic Diagnosis of Blastocystis hominis in Peritoneal Fluid

et al. 2008

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Section: Discussionsupporting

confidence: 82%

Cytologic Diagnosis of Blastocystis hominis in Peritoneal Fluid

et al. 2008

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“…In contrast, Leder et al (2005) denied any correlation between clinical symptoms and B. hominis. Also, Horiki et al (1999) stated that B. hominis was not related to the occurrence of colon cancer in humans.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological variability of different genotypes of human Blastocystis hominis Egyptian isolates in experimentally infected rats

et al. 2008

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The genotyping of Blastocystis hominis clinical isolates obtained from 28 gastrointestinal symptomatic patients and 16 asymptomatic individuals were identified by polymerase chain reaction using sequenced-tagged site (STS) primers. Then, pathophysiological variability between different B. hominis genotypes was evaluated in experimentally infected rats. Only four B. hominis subtypes (1, 2, 3, and 4) were detected (18.2%, 9.1%, 54.5%, and 18.2%, respectively) in human isolates. In symptomatic isolates, subtypes 1, 3, and 4 were detected in 8 (28.6%), 16 (57.1%), and 4 (14.3%) patients, respectively. In asymptomatic isolates, subtypes 2, 3, and 4 were identified in 4 (25%), 8 (50%), and 4 (25%), respectively. Subtype 3 was the commonest in humans. Different degrees of pathological changes were found among infected rats by symptomatic subtypes compared with asymptomatic subtypes. The moderate and severe degrees of pathological changes were found only in symptomatic subtypes infected rats while mild degree was found only in asymptomatic subtypes infected rats. Only subtype 1 induced mortality rate with 25% among infected rats. On evaluation of the intestinal cell permeability in the Ussing chamber, a prominent increase in short circuit current (DeltaIsc) was found in symptomatic subtype 1 compared to symptomatic subtypes 3 and 4 infected rats. Minimal effects were found in the asymptomatic and control groups. The results proved that subtype 1 was clinically and statistically highly relevant to the pathogenicity of B. hominis while subtype 2 was irrelevant. Also, the results suggest the presence of pathogenic and nonpathogenic strains among subtypes 3 and 4.

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“…The most common symptoms in these patients are abdominal pain, diarrhea, and flatulence [32]. One study reported an overgrowth of Blastocystis after carcinoma-induced intestinal obstruction [33]. A recent case study described Blastocystis in abdominal fluid of a patient with adenocarcinoma and associated bowel perforation [8].…”

Section: Patients With Cancermentioning

confidence: 99%

Current Views on the Clinical Relevance of Blastocystis spp.

Tan

Mirza

Teo

et al. 2010

Curr Infect Dis Rep

180

174

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Blastocystis is an enteric protistan parasite of uncertain clinical relevance. Recent studies indicate that the parasite is a species complex and humans are potentially hosts to nine Blastocystis subtypes, most of which are zoonotic. Subtype 3 is the most common in prevalence studies, followed by subtype 1. Laboratory diagnosis is challenging; the currently recommended diagnostic approach is trichrome staining of direct smears coupled with stool culture. Polymerase chain reaction testing from stools or culture is useful for determining Blastocystis subtype information. The controversial pathogenesis of Blastocystis is attributed to subtype variations in virulence; although current studies seem to support this idea, evidence suggests other factors also contribute to the clinical outcome of the infection. Clinical signs and symptoms of blastocystosis include abdominal pain, diarrhea, bloating, and flatulence. Extraintestinal manifestations, predominantly cutaneous, also were reported. In vitro and animal studies shed new light on the pathobiology of Blastocystis.

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Intestinal blockage by carcinoma and Blastocystis hominis infection.

Cited by 28 publications

References 15 publications

Cytologic Diagnosis of Blastocystis hominis in Peritoneal Fluid

Cytologic Diagnosis of Blastocystis hominis in Peritoneal Fluid

Pathophysiological variability of different genotypes of human Blastocystis hominis Egyptian isolates in experimentally infected rats

Current Views on the Clinical Relevance of Blastocystis spp.

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