Intestinal Cancer in Patients with Crohn's Disease: A Population Study in Central Israel

Fireman, Zvi; Grossman, Alon; Lilos, Pearl; Hacohen, Dalia; Meir, S. Bar; Rozen, Paul; Gilat, Tuvia

doi:10.3109/00365528909093058

Cited by 106 publications

(47 citation statements)

References 8 publications

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“…Those who were less than 30 years old at the time of diagnosis of CD had a higher relative risk than those diagnosed at an older age. In pa tients with any colonic involvement, diagno sis at an early age entailed a comparative risk of 20.9, compared with 2.2 in those diagnosed after age 30 [8], Four earlier population-based studies found no association between CD and colo rectal cancer [20][21][22][23], However, all four failed to correct their data for the small subsets of their populations that were actually at risk, namely those with extensive, long-standing, unresected colonic disease.…”

Section: Risk In CDmentioning

confidence: 77%

Inflammatory Bowel Disease and Colon Cancer: A Review

Jain

Peppercorn²

1997

Dig Dis

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Extensive and long-standing colitis due to Crohn’s disease and ulcerative colitis is associated with an increased incidence of colorectal cancer. Colonoscopy with biopsies for mucosal dysplasia can help stratify those patients who are at increased risk. However, the effectiveness of surveillance programs has been questioned. Newer molecular techniques may eventually lead to the development of more accurate screening tools, but at this time there is not enough evidence to support their widespread use.

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Section: Risk In CDmentioning

confidence: 77%

Inflammatory Bowel Disease and Colon Cancer: A Review

Jain

Peppercorn²

1997

Dig Dis

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“…In Crohn disease patients, the distribution of adenocarcinoma mirrors that of inflammation. Therefore, Crohn diseaserelated adenocarcinoma more frequently occurs in the Several studies have shown an increased risk for developing adenocarcinoma in the small bowel in Crohn disease patients, with a relative risk 15-50 times greater than that of the general population [2,[32][33][34]. The cumulative risk has been reported as 0.2% at 10 years, and 2.2% at 25 years after the onset of the disease [6].…”

Section: Discussionmentioning

confidence: 97%

Small bowel adenocarcinoma in Crohn disease: CT-enterography features with pathological correlation

et al. 2011

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“…The appearance of colorectal cancer in our patients with Crohn’s disease is a reality, despite the fact that Greece, due to environmental and other factors, has the lowest incidence of colorectal cancer among the European Union countries. We must bear in mind, however, that in some Mediterranean countries such as Israel [45]and countries of north Europe (Sweden) [46], the incidence of colorectal cancer among patients with Crohn’s disease is not different from that expected in the general population.…”

Section: Discussionmentioning

confidence: 99%

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

Triantafillidis

Emmanouilidis²,

Manousos³

et al. 2000

Digestion

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The aim of this prospective study was to elucidate the clinical features and natural history of Crohn’s disease in Greece. One hundred and fifty-five Greek patients with definite diagnosis of Crohn’s disease were followed-up for a mean period of 9.7 years and evaluated for clinical patterns and course of illness. The male/female ratio was 1.58:1. The peak incidence of the disease was observed between 20 and 30 years of age. The majority of patients were urban dwellers and of higher socio-economic level compared to the general population of Greece. In almost 50% of the patients symptoms of the disease started below the age of 30, although in almost one in every 5 cases, symptoms appeared after the age of 50. Familial clustering of inflammatory bowel disease was observed in 1.3%. The pattern of anatomic involvement was: ileocolic 33.3%, colon 33.3% and small bowel 33.3%. The kind of predominant symptoms at the time of diagnosis was related to the anatomic location of the disease. At least one extraintestinal manifestation appeared in 42% of patients. Perianal disease was noticed in 21.3% with fistulae and abscesses being the most common manifestation. Fifty-one percent of patients were operated upon at least once during the follow-up period because of acute abdomen, bad response to conservative treatment and fistulae and abscesses. Emergency operation was required in 17.3% of the patients. Evolution to cancer was observed in 3 patients (2%). During the follow-up period of 9.7 ± 6.5 years, 18 patients (11.6%) died. A considerable mortality was noticed in the surgically treated group of patients, while in the nonoperated group the disease was running with milder symptoms. It is concluded that some of the clinicoepidemiological characteristics of patients with Crohn’s disease in Greece are in accordance with those reported from western as well as the neighboring Mediterranean countries. However, other parameters such as the higher incidence of the disease in males, the low incidence of familial clustering, and the low incidence of perianal disease, underline the importance of environmental, genetic and other factors on the evolution and behavior of the disease in different parts of the world.

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Intestinal Cancer in Patients with Crohn's Disease: A Population Study in Central Israel

Cited by 106 publications

References 8 publications

Inflammatory Bowel Disease and Colon Cancer: A Review

Inflammatory Bowel Disease and Colon Cancer: A Review

Small bowel adenocarcinoma in Crohn disease: CT-enterography features with pathological correlation

Clinical Patterns of Crohn’s Disease in Greece: A Follow-Up Study of 155 Cases

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