Intestinal Carbohydrate Dyspepsia

Hurst, Arthur F.; Knott, F. A.

doi:10.1093/qjmed/os-24.94.171

Cited by 20 publications

(6 citation statements)

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“…As such, carbohydrate-rich foods are particularly incriminated by the patients [5,17,55]. Indeed, a causal relationship between intake of heavily absorbable carbohydrates and chronic abdominal distress was suspected by physicians in the beginning of the last centurya phenomenon described as "Gährungsdyspepsie" by Schmidt and Strasburger in 1901 [56], and "Intestinal carbohydrate dyspepsia" by Hurst and Knott in 1932 [57]. These conditions were once recognized by highly respected clinicians, but fell into disrepute in the early 1970s, seemingly because high fiber diets became fashionable around that time [58].…”

Section: Studies On Intestinal Fermentationmentioning

confidence: 99%

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Lied

Lillestøl

Lind

et al. 2011

Scandinavian Journal of Gastroenterology

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Perceived food hypersensitivity is a prevalent, but poorly understood condition. In this review article, we summarize narratively recent literature including results of our 10 years' interdisciplinary research program dealing with such patients. The patients (more than 400) included in our studies were all adults referred to a university hospital because of gastrointestinal complaints self-attributed to food hypersensitivity. Despite extensive examinations, food allergy was seldom diagnosed. The majority of the patients fulfilled the diagnostic criteria for irritable bowel syndrome. In addition, most suffered from several extra-intestinal health complaints and had considerably impaired quality of life. However, psychological factors could explain only approximately 10% of the variance in the patients' symptom severity and 90% of the variance thus remained unexplained. Intolerance to low-digestible carbohydrates was a common problem and abdominal symptoms were replicated by carbohydrate ingestion. A considerable number of patients showed evidence of immune activation by analyses of B-cell activating factor, dendritic cells and "IgE-armed" mast cells. Multiple factors such as immune activation, disturbed intestinal fermentation, enteric dysmotility, post-infectious changes and "local" allergy in the gut as well as psychological disturbances may play a role in the pathophysiology of perceived food hypersensitivity. Hence, our results support the view that management of these patients should be interdisciplinary.

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Section: Studies On Intestinal Fermentationmentioning

confidence: 99%

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Lied

Lillestøl

Lind

et al. 2011

Scandinavian Journal of Gastroenterology

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“…The authors' incorporation of records of pancreatic secretion levels was because the study tool, the gastrogram, enabled these measurements to be made and it seemed wrong to ignore them. The authors had formed no estimate of the extent to which pancreatic function might be affected, although on an empirical basis, earlier workers routinely advised pancreatic supplements for these patients [11,12].…”

Section: Discussionmentioning

confidence: 99%

Gastric Acid Production, Pancreatic Secretions and Blood Levels of Higher Alcohols in Patients with Fungal-type Dysbiosis of the Gut

Eaton¹,

Gaier

Howard³

et al. 2002

Journal of Nutritional & Environmental Medicine

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Purpose: Patients with gut dysbioses are clinically dif cult to distinguish from those with food intolerance. The variety known as fungal-type is associated with the generation of small amounts of ethanol in the blood. A recent study has shown abnormalities of histidine metabolism. In view of this, gastric function was studied. This also provided data on pancreatic function. Design: Two groups of newly referred patients, with similar symptom pro les, attending two clinicians were studied. Group A (42 patients) had positive ethanol fermentation tests: group B (37 patients) did not. There were 20 healthy control subjects. Levels of higher alcohols, short-chain fatty acids, gastric acid production and pancreatic exocrine secretions were measured and compared statistically. Materials and Methods: Ethanol, higher alcohols and short-chain fatty acids were measured by gas-liquid chromatography. Gastric acid production, emptying time and pancreatic function were measured using a swallowed transducer. Results: A signi cant number of group A patients had elevated levels of higher alcohols;all of these also showed excess short-chain fatty acids. Group B patients showed similar ndings for both; these gures were not statistically signi cant. However, as compared with group B, group A patients were less likely to show lower levels of gastric acid and/or pancreatic enzyme production and these results were statistically highly signi cant. Conclusions: As these ndings show minimal effects on stomach and duodenum, it is suggested that fungal-type dysbiosis is largely an ileal condition. For these patients, the presence of elevated levels of higher alcohols with a positive ethanol test is a better indicator of disease severity.

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“…High carbohydrate intake in some of these patients prompted diagnostic labels such as germ-carbohydrate fermentation and intestinal carbohydrate dyspepsia [3] in the early 20th century, while later attempts include descriptions of the candidiasis hypersensitivity syndrome [4] gut fermentation syndrome [5] fungal type dysbiosis [6][7][8][9] and abnormal gut fermentation [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome

Santelmann

Howard²

2005

European Journal of Gastroenterology & Hepatology

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Many patients with irritable bowel syndrome (IBS) are disillusioned by the lack of efficacy of treatments and suffer from numerous symptoms not covered by the Rome criteria for IBS, as the current empirical treatment regimes fail to address these persistent debilitating 'IBS associated symptoms'. These symptoms are similar to other symptom complexes like chronic fatigue and the so called 'candida syndrome', and many seek help from alternative medicine. The possible role of Candida and yeasts in non-immune compromised individuals is disputed and is the subject of this review. Even if the involvement of yeasts in the aetiology of IBS still remains unclear, there is increasing evidence for yeasts being able to cause IBS-symptoms in sensitized patients via Candida products, antigens and cross-antigens. But more research is needed before antifungal treatment can be recommended as a first line treatment for IBS.

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Intestinal Carbohydrate Dyspepsia

Cited by 20 publications

References 0 publications

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Gastric Acid Production, Pancreatic Secretions and Blood Levels of Higher Alcohols in Patients with Fungal-type Dysbiosis of the Gut

Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome

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