Intestinal Crosstalk between Microbiota and Serotonin and its Impact on Gut Motility

Ge, Xiaolong; Pan, Junhai; Liu, Yichang; Wang, Hongkan; Zhou, Wei; Wang, Xianfa

doi:10.2174/1389201019666180528094202

Cited by 59 publications

(45 citation statements)

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“…Microbiota products such as bile acids and SCFA affect the production of serotonin, which in turn regulates gut motility (Fig. 1) [45]. Interestingly, the number of spontaneous gut passages has been related to NEC development, suggesting that microbiota have an effect on both gut function and subsequent disease.…”

Section: Microbiota and Necmentioning

confidence: 99%

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

et al. 2019

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Necrotizing enterocolitis (NEC) is a relatively common disease in very-low-birth-weight infants and is associated with high mortality and morbidity. In survivors, neurodevelopmental impairment is frequently seen. The exact etiology remains largely to be elucidated, but microbiota are considered to play a major role in the development of NEC. Furthermore, emerging evidence exists that the microbiota is also of importance in brain function and development. Therefore, microbiota characterization has not only potential as a diagnostic or even preventive tool to predict NEC, but may also serve as a biomarker to monitor and possibly even as a target to manipulate brain development. Analysis of fecal volatile organic compounds, which shape the volatile metabolome and reflect microbiota function and host interaction, has been shown to be of interest in the diagnosis of NEC and late-onset sepsis. In this review, we discuss evidence of the role of the complex interplay between microbiota, NEC, and brain development, including the brain-gut axis in preterm infants.

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Section: Microbiota and Necmentioning

confidence: 99%

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

et al. 2019

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“…As is common in gut dysbiosis, levels of SCFAs such as butyrate are decreased in ASD ( 18 ). Butyrate inhibits histone deacetylase (HDAC) enzymes which participate in the serotonergic system ( 19 ), and can induce melatonin ( 20 ). Elevated whole-blood serotonin levels were observed in patients with ASD following meta-analysis ( 21 ), and levels of melatonin in urine, plasma, and the pineal gland are also lower in patients with ASD ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders

et al. 2020

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Background Autism spectrum disorder (ASD) is a type of neurodevelopmental disease that is frequently accompanied by sleep disorder. Herein, we investigated changes in the gut microbiota and its metabolites correlated with core symptoms and sleep problems in children with ASD. Methods One hundred and twenty children diagnosed with ASD based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria were enrolled in our study. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood Autism Rating Scale (CARS) were used to assess autism symptoms, and the Children Sleep Habits Questionnaire (CSHQ) was employed to evaluate sleep problems in children with ASD. The 120 children were divided into a sleep disorder group (n = 60) and a control group without sleep disorder (n = 60) according to the CSHQ answers. Illumina MiSeq analysis of 16S rRNA genes was used to compare differences in gut microbiota, and metabolomics analysis was employed to asses associated metabolites. Results SRS and CARS scores for the sleep disorder group were significantly higher than for the control group ( p < 0.05). The abundances of butyrate-producing bacteria Faecalibacterium and Agathobacter were reduced significantly in the sleep disorder group ( p < 0.05), and this was negatively correlated with CSHQ score ( p = 0.007 and p = 0.014, respectively). The abundance of Agathobacter was also negatively associated with the ABC language score ( p = 0.044). Furthermore, levels of 3-hydroxybutyric acid and melatonin were significantly lower ( p < 0.05) while serotonin levels were higher ( p < 0.05) in the sleep disorder group. The 3-hydroxybutyric acid level was positively associated with Faecalibacterium abundance ( p = 0.000), and melatonin was positively associated with the abundance of Faecalibacterium ( p = 0.036) and Agathobacter ( p = 0.041). We also observed negative correlations between 3-hydroxybutyric acid and CSHQ ( p = 0.000) and CARS ( p = 0.009), between melatonin and CSHQ ( p = 0.002) and ABC sensory score ( p = 0.021), and a positive correlation between serotonin and CSHQ ( p = 0.002) and ABC sensory score ( p = 0.025). Conclusions ASD children with sleep disorder exhibited declines in the abundance of Faecalibacterium and Agathobacter , decreased leve...

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“…In terms of diet, it can directly tune enteric neuron activity and regulate the construction and function of intestinal microbes [6]. The gut flora possesses huge potential in the biosynthesis and biotransformation of intestinal neurotransmitters such as 5-HT, which is an important monoamine involved in controlling GI movement and neural functions [28]. Results of this study indicate that electroacupuncture can significantly restore the α diversity of intestinal microbiota.…”

Section: Discussionmentioning

confidence: 99%

Regulating the Enteric Nervous System against Obesity in Mice by Electroacupuncture

Ding

Chen

Zhong

et al. 2020

Neuroimmunomodulation

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Background and Objectives: The enteric nervous system (ENS) dominates the onset of obesity and has been shown to regulate nutrient absorption and energy metabolism. Methods and Study Design: This study was performed to investigate the role of electroacupuncture in regulating ENS function in obese mice. Obese mice were obtained by highfat diet. 16S rRNA pyrosequencing, Western blotting, quantitative PCR, and neurotransmitter analysis were used for this purpose. Results: Body weight, Lee index, serum lipid, leptin, and adiponectin levels, and other basic indices were significantly ameliorated after electroacupuncture intervention. The pathological ENS scores, serum neurotransmitter levels, and intestinal transit rate were markedly changed in obese mice. Moreover, electroacupuncture promoted the diversity of gut microbiota. No significant differences were observed 21 and 28 days after electroacupuncture. Conclusions: These results suggested ENS may be a new treatment approach to obesity.

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Intestinal Crosstalk between Microbiota and Serotonin and its Impact on Gut Motility

Cited by 59 publications

References 0 publications

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders

Regulating the Enteric Nervous System against Obesity in Mice by Electroacupuncture

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