Intestinal Delivery of Probiotics: Materials, Strategies, and Applications

Li, Chengcheng; Wang, Zi‐Xi; Xiao, Huining; Wu, Fu‐Gen

doi:10.1002/adma.202310174

Cited by 8 publications

(1 citation statement)

References 236 publications

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“…Natural polymer-based materials (e.g., polysaccharides, proteins, and lipids) are biocompatible, food-grade, biodegradable, and widely available, making them ideal matrixes for protection and controlled delivery of probiotics [ 7 ]. For example, proteins, including soybean protein, whey protein, and soybean protein isolate (SPI), etc., are used as encapsulation materials for probiotics due to their low cost, abundant sources, and high nutritional properties [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Delivery of Probiotics with Cellulose-Based Films and Their Food Applications

Yang,

Zhang,

2024

Polymers

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Probiotics have attracted great interest from many researchers due to their beneficial effects. Encapsulation of probiotics into biopolymer matrices has led to the development of active food packaging materials as an alternative to traditional ones for controlling food-borne microorganisms, extending food shelf life, improving food safety, and achieving health-promoting effects. The challenges of low survival rates during processing, storage, and delivery to the gut and low intestinal colonization, storage stability, and controllability have greatly limited the use of probiotics in practical food-preservation applications. The encapsulation of probiotics with a protective matrix can increase their resistance to a harsh environment and improve their survival rates, making probiotics appropriate in the food packaging field. Cellulose has attracted extensive attention in food packaging due to its excellent biocompatibility, biodegradability, environmental friendliness, renewability, and excellent mechanical strength. In this review, we provide a brief overview of the main types of cellulose used for probiotic encapsulation, as well as the current advances in different probiotic encapsulating strategies with cellulose, grafted cellulose, and cellulose-derived materials, including electrospinning, cross-linking, in-situ growth, casting strategies, and their combinations. The effect of cellulose encapsulation on the survival rate of probiotics and the patented encapsulated probiotics are also introduced. In addition, applications of cellulose-encapsulated probiotics in the food industry are also briefly discussed. Finally, the future trends toward developing encapsulated probiotics with improved health benefits and advanced features with cellulose-based materials are discussed.

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Section: Introductionmentioning

confidence: 99%

Delivery of Probiotics with Cellulose-Based Films and Their Food Applications

Yang,

Zhang,

2024

Polymers

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Probiotics‐Loaded Selenium Nanoparticles Effectively Alleviated DSS‐Induced Colitis by Scavenging ROS and Remodeling Intestinal Innate Immune and Microbiota

Yao,

Xue,

Lessing

et al. 2024

Advanced Therapeutics

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Alterations in the intestinal microenvironment, including increased levels of reactive oxygen species (ROS), abnormalities in intestinal mucosal immune regulation, and dysbiosis of the intestinal microbiota, are crucial to the development of inflammatory bowel disease (IBD). Herein, an oral colon‐targeting Se‐Probiotic@Alginate bead (BLSe) with ROS‐scavenging ability and gut immune‐microbiota microenvironment remodeling ability is developed using alginate as the primary outer shell encapsulated with probiotics Bacillus licheniformis (BL) and selenium nanoparticles stabilized by yeast glucan (SeNPs). In vitro studies have shown that SeNPs possess antioxidant activity and BLSe exhibits excellent stability in gastric fluids and are released in intestinal fluids. In vivo studies have also shown that BLSe significantly alleviated dextran sulphate sodium (DSS)‐induced colitis in mice by inhibiting colon shortening, enhancing antioxidant activity, reducing pro‐inflammatory cytokine secretion, and protecting the intestinal mucosal barrier. 16S ribosomal RNA sequencing shows that BLSe can remodel the composition of the gut microbiota by improving bacterial diversity and restoring the relative abundance of beneficial bacteria in the colon. Overall, this study advances a promising probiotic‐based nanomedicine for managing IBD.

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Review: Biomacromolecules‐based encapsulation technologies for the protection of oxygen‐sensitive next‐generation probiotics

Phùng,

Karbowiak

2024

Food Biomacromolecules

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In the recent years, various strains of the gut microbiota have been discovered to possess significant therapeutic potential, they are defined as next‐generation probiotics (NGPs). Akkermansia, Faecalibacterium, Bacteriodes, Eubacterium, and Bifidobacteria are among the typical NGP strains which exhibit several interesting bioactivities as live biotherapeutics. However, some strains of NGP are extremely sensitive to oxygen, such as Faecalibacterium prausnitzii. This hinders their cultivation and large‐scale production. Therefore, it is essential to develop a strategy to protect them during production, storage, and colonic administration. This review, highlights key NGP strains developed in recent years, alongside the encapsulation strategies used to protect them. The primary criterion for selecting encapsulating techniques is their feasibility to be performed under strictly anaerobic conditions. Various processes have been selected according to the physical forms of the products, including liquid, gel, and solid forms, as well as the final shaping of the product. The critical factors for selecting encapsulation materials include biocompatibility, safety, effective oxygen barrier properties, and an optimal release profile in the gastrointestinal tract. This review discusses protection strategies aimed at improving the survival and thereby effectiveness of NGPs.

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Intestinal Delivery of Probiotics: Materials, Strategies, and Applications

Cited by 8 publications

References 236 publications

Delivery of Probiotics with Cellulose-Based Films and Their Food Applications

Delivery of Probiotics with Cellulose-Based Films and Their Food Applications

Probiotics‐Loaded Selenium Nanoparticles Effectively Alleviated DSS‐Induced Colitis by Scavenging ROS and Remodeling Intestinal Innate Immune and Microbiota

Review: Biomacromolecules‐based encapsulation technologies for the protection of oxygen‐sensitive next‐generation probiotics

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