Intestinal disorders caused by scurvy

Poussier, M.; Osmak, Liliana; Naouri, A.; Rouber, X

doi:10.1016/j.clinre.2013.08.010

Cited by 2 publications

(5 citation statements)

References 4 publications

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“…Furthermore, a comparison between plasma levels of ascorbate and pool sizes showed a very poor correlation… In general, it is fair to say that scurvy appeared when the body pool fell below 300 mg” ([56], p. 441). The most undisputable evidence of scurvy symptoms is that they disappear with vitamin C administration [13,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185].…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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Section: Discussionmentioning

confidence: 99%

“… 13 Treatment consists of high doses of vitamin C up to 1 g initially followed by a maintenance dose. 13 …”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C measurement in either serum or urine can be used with accuracy, with a level below 0.25 mg/dL suggestive of scurvy. 13 Treatment consists of high doses of vitamin C up to 1 g initially followed by a maintenance dose. 13 Our patient's symptoms presented us with many diagnostic challenges over the 9 months that she had her oral ulcers and other nonspecific symptoms, before her easy bruising and perifollicular hemorrhage occurred.…”

Section: Case Descriptionmentioning

confidence: 99%

“…13 Treatment consists of high doses of vitamin C up to 1 g initially followed by a maintenance dose. 13 Our patient's symptoms presented us with many diagnostic challenges over the 9 months that she had her oral ulcers and other nonspecific symptoms, before her easy bruising and perifollicular hemorrhage occurred. Systemic autoimmunity was suspected early on, and when her 14. cutaneous vasculitis occur.…”

Section: Case Descriptionmentioning

confidence: 99%

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Sailing the ship of life: scurvy and autoimmunity . . .

Essien

Jacocks

Carroll

2022

Therapeutic Advances in Chronic Disease

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Celiac disease (CD) is a multisystem disorder known to manifest in a multitude of ways to include diarrhea, anemia, and nutritional deficiencies. The malabsorptive state can present as certain classical conditions such as autoimmune gastritis and osteopenia/osteoporosis but scurvy is less recognized within the literature. In this case, we present a unique presentation of scurvy as a result of an undiagnosed CD.

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Intestinal disorders caused by scurvy

Cited by 2 publications

References 4 publications

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Sailing the ship of life: scurvy and autoimmunity . . .

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