Intestinal GLUT5 and FAT/CD36 transporters and blood glucose are reduced by a carotenoid/MUFA-rich oil in high-fat fed mice

Evangelista-Silva, Paulo Henrique; Prates, Rodrigo Pereira; Leite, Jaqueline Santos Moreira; Moreno, Lauane Gomes; Goulart-Silva, Francemilson; Esteves, Elizabethe Adriana

doi:10.1016/j.lfs.2021.119672

Cited by 8 publications

(2 citation statements)

References 57 publications

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“…The genes Scarb1 , CD36 , Stard3 , Stard5 , ApoD , GstP1 , Bcom1 and Bco2 , which play important roles in carotenoid metabolism, were found to be affected by TPT exposure. It has been reported that Scarb1 and CD36 are involved in the regulation of carotenoid pigments in body color [ 55 ]. They play a key role in carotenoid absorption [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Triphenyltin Influenced Carotenoid-Based Coloration in Coral Reef Fish, Amphiprion ocellaris, by Disrupting Carotenoid Metabolism

Zhang,

Cai,

Hou

et al. 2023

Toxics

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Triphenyltin (TPT), a kind of persistent pollutant, is prevalent in the aquatic environment and could pose a threat to coral reef fish. However, little is known about the toxicity of TPT on coral reef fish, especially regarding the representative characteristics of body coloration. Therefore, this study chose the clownfish (Amphiprion ocellaris) in order to investigate the effects of TPT exposure on its carotenoid-based body coloration under the environmentally relevant concentrations (0, 1, 10 and 100 ng/L). After TPT exposure for 60 d, the carotenoid contents were decreased and histological damage in the liver was found, shown as nuclear pyknosis and shift, lipid deposition and fibrotic tissue hyperplasia. Liver transcriptomic analysis showed that TPT exposure interfered with oxidative phosphorylation and fatty acid metabolism pathways, which related to carotenoids uptake and metabolism. Furthermore, TPT exposure led to oxidative damage in the liver, which is responsible for the changes in the antioxidant capacity of enzymes, including GSH, MDA, POD, CAT and T-SOD. TPT exposure also affected the genes (Scarb1, CD36, Stard3 and Stard5) related to carotenoid absorption and transport, as well as the genes (GstP1 and Bco2) related to carotenoid deposition and decomposition. Taken together, our results demonstrate that TPT influenced carotenoid-based coloration in coral reef fish by disrupting carotenoid metabolism, which complements the ecotoxicological effects and toxic mechanisms of TPT and provides data for the body color biology of coral reef fishes.

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Section: Discussionmentioning

confidence: 99%

Triphenyltin Influenced Carotenoid-Based Coloration in Coral Reef Fish, Amphiprion ocellaris, by Disrupting Carotenoid Metabolism

Zhang,

Cai,

Hou

et al. 2023

Toxics

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“…Incredibly, even primary intestinal cells cultured in vitro were able to be induced to express GLUT5 by fructose [65] . Interestingly, a recent study suggests that intestinal GLUT5 expression level may also be associated with lipid intake [66] . This implies that not only saccharides but also other types of nutrients may be involved in the regulation of GLUT5 expression.…”

Section: Physiological Expression Regulation Of Glut5 In Mammalsmentioning

confidence: 99%

GLUT5: structure, functions, diseases and potential applications

Song¹,

Mao²,

Wei³

2023

ABBS

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Glucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GLUT5 in human cancer has received widespread attention, and a large number of studies have focused on exploring the effects of changes in GLUT5 expression levels on cancer cell survival, metabolism and metastasis. However, due to various difficulties and shortcomings, the molecular structure and mechanism of GLUT5 have not been fully elucidated, which to some extent prevents us from revealing the relationship between GLUT5 expression and cell carcinogenesis at the protein molecular level. In this review, we summarize the current understanding of the structure and function of mammalian GLUT5 and its relationship to intestinal diseases and cancer and suggest that GLUT5 may be an important target for cancer therapy.

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Effect of Caryocar coriaceum Wittm. fixed oil on body weight and metabolic parameters of mice fed a high-fat diet

da Silva,

Borges,

de Alencar

et al. 2024

Food Chemistry Advances

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Intestinal GLUT5 and FAT/CD36 transporters and blood glucose are reduced by a carotenoid/MUFA-rich oil in high-fat fed mice

Cited by 8 publications

References 57 publications

Triphenyltin Influenced Carotenoid-Based Coloration in Coral Reef Fish, Amphiprion ocellaris, by Disrupting Carotenoid Metabolism

Triphenyltin Influenced Carotenoid-Based Coloration in Coral Reef Fish, Amphiprion ocellaris, by Disrupting Carotenoid Metabolism

GLUT5: structure, functions, diseases and potential applications

Effect of Caryocar coriaceum Wittm. fixed oil on body weight and metabolic parameters of mice fed a high-fat diet

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