Intestinal Host-Microbiome Interactions

Tjalsma, Harold; Boleij, Annemarie

doi:10.5772/30225

Cited by 2 publications

(2 citation statements)

References 125 publications

(124 reference statements)

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“…The feces sampled for this study reflect the bacterial flora of the lower large intestine. However, mucosa‐associated bacteria differ from those recovered from feces and are rather uniformly distributed throughout the colon . Both diseases are associated with bacterial fermentation and generation of d ‐lactate and other substances.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Fecal Flora in Goat Kids with and without Floppy Kid Syndrome

Bleul¹,

Fassbind

Ghielmetti³

et al. 2013

Veterinary Internal Medicne

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Background: Floppy kid syndrome (FKS) affects goat kids in the first month of life and is associated with high morbidity and mortality rates. The condition is characterized by neurological signs that can be ascribed to increased plasma D-lactate concentrations. The source of D-lactate has not been identified conclusively, but D-lactate-producing bacteria in the large intestine are thought to be involved.Objectives: To determine the number of colony-forming unit (CFUs) of certain groups of bacteria in the feces of kids with and without FKS.Animals: Nineteen goat kids with clinical signs of FKS, acidemia (pH ≤ 7.2), and plasma D-lactate concentration >7 mM and 15 healthy goat kids without acidemia (pH >7.2) and D-lactate concentration <1 mM.Methods: In this case-control study, the goat kids were examined clinically and blood was collected to measure D-lactate concentration, blood gases, and acid-base parameters. Fecal samples were collected and the total aerobic bacterial count and CFU counts of coliforms, enterococci, staphylococci, streptococci, lactobacilli, and clostridia were determined using the surface plating method.Results: Goat kids with FKS had a mean plasma D-lactate concentration of 10.9 AE 3.7 mM compared with 0.3 AE 0.9 mM in healthy kids, and significantly greater CFU counts for enterococci, streptococci, staphylococci, and lactobacilli than healthy kids.Conclusions and Clinical Importance: The groups of bacteria present in greater numbers in the feces of goat kids with FKS include several D-lactate-producing species, which makes dysbacteriosis a likely cause of the increased plasma D-lactate concentration in FKS.

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Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Fecal Flora in Goat Kids with and without Floppy Kid Syndrome

Bleul¹,

Fassbind

Ghielmetti³

et al. 2013

Veterinary Internal Medicne

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“…E. Coli strains can be classified into 4 main categories based on phylogenetic analyses: A, B1, B2, and D. 45 Most commensal strains belong to group A, while virulent extra-intestinal strains primarily belong to group B2 and, to a lesser extent, group D. 46 Although E. coli is a common gut bacterium that is recovered from both colorectal cancer patients and healthy controls, yet, colorectal cancer patients have more pathogenic strains of E. coli than healthy persons. 47 , 48 Aside from other cyclomodulins produced by E. coli such as cytolethal distending toxins and cytotoxic necrotizing factors, these pathogenic strains also produce colibactin, which when in contact with mammalian cells, is capable of inducing a specific cytopathic effect known as megalocytosis. 49 …”

Section: Pathogenic Bacteria and Colorectal Cancermentioning

confidence: 99%

Microbiome Dysbiosis, Dietary Intake and Lifestyle-Associated Factors Involve in Epigenetic Modulations in Colorectal Cancer: A Narrative Review

Kwao-Zigah,

Bediako-Bowan,

Boateng

et al. 2024

Cancer Control

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Background: Colorectal cancer is the second cause of cancer mortality and the third most commonly diagnosed cancer worldwide. Current data available implicate epigenetic modulations in colorectal cancer development. The health of the large bowel is impacted by gut microbiome dysbiosis, which may lead to colon and rectum cancers. The release of microbial metabolites and toxins by these microbiotas has been shown to activate epigenetic processes leading to colorectal cancer development. Increased consumption of a ‘Westernized diet’ and certain lifestyle factors such as excessive consumption of alcohol have been associated with colorectal cancer. Purpose: In this review, we seek to examine current knowledge on the involvement of gut microbiota, dietary factors, and alcohol consumption in colorectal cancer development through epigenetic modulations. Methods: A review of several published articles focusing on the mechanism of how changes in the gut microbiome, diet, and excessive alcohol consumption contribute to colorectal cancer development and the potential of using these factors as biomarkers for colorectal cancer diagnosis. Conclusions: This review presents scientific findings that provide a hopeful future for manipulating gut microbiome, diet, and alcohol consumption in colorectal cancer patients’ management and care.

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Intestinal Host-Microbiome Interactions

Cited by 2 publications

References 125 publications

Quantitative Analysis of Fecal Flora in Goat Kids with and without Floppy Kid Syndrome

Quantitative Analysis of Fecal Flora in Goat Kids with and without Floppy Kid Syndrome

Microbiome Dysbiosis, Dietary Intake and Lifestyle-Associated Factors Involve in Epigenetic Modulations in Colorectal Cancer: A Narrative Review

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