Intestinal Immune Imbalance is an Alarm in the Development of IBD

Hu, Chunli; Liao, Shengtao; Lv, Lin; Li, Chuanfei; Mei, Zhechuan

doi:10.1155/2023/1073984

Cited by 8 publications

(4 citation statements)

References 246 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IBD benefits from resveratrol's therapeutic effects. In both Crohn's disease (CD) and ulcerative colitis (UC), it reduces pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and restores the balance between Tregs and Th17 cells [103,104]. Furthermore, resveratrol demonstrates a neuroprotective role in vitro and in vivo, showcasing its potential in tackling neurodegenerative diseases.…”

Section: Targeting Inflammation Using Natural Compoundsmentioning

confidence: 99%

Immune Diseases Associated with Aging: Molecular Mechanisms and Treatment Strategies

Kim,

Lee

2023

IJMS

View full text Add to dashboard Cite

Aging is associated with a decline in immune function, thereby causing an increased susceptibility to various diseases. Herein, we review immune diseases associated with aging, focusing on tumors, atherosclerosis, and immunodeficiency disorders. The molecular mechanisms underlying these conditions are discussed, highlighting telomere shortening, tissue inflammation, and altered signaling pathways, e.g., the mammalian target of the rapamycin (mTOR) pathway, as key contributors to immune dysfunction. The role of the senescence-associated secretory phenotype in driving chronic tissue inflammation and disruption has been examined. Our review underscores the significance of targeting tissue inflammation and immunomodulation for treating immune disorders. In addition, anti-inflammatory medications, including corticosteroids and nonsteroidal anti-inflammatory drugs, and novel approaches, e.g., probiotics and polyphenols, are discussed. Immunotherapy, particularly immune checkpoint inhibitor therapy and adoptive T-cell therapy, has been explored for its potential to enhance immune responses in older populations. A comprehensive analysis of immune disorders associated with aging and underlying molecular mechanisms provides insights into potential treatment strategies to alleviate the burden of these conditions in the aging population. The interplay among immune dysfunction, chronic tissue inflammation, and innovative therapeutic approaches highlights the importance of elucidating these complex processes to develop effective interventions to improve the quality of life in older adults.

show abstract

Section: Targeting Inflammation Using Natural Compoundsmentioning

confidence: 99%

Immune Diseases Associated with Aging: Molecular Mechanisms and Treatment Strategies

Kim,

Lee

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Similar to IgAN with unclear etiology and pathogenesis, IBD is a troublesome heterogeneous disease with an unignorable influence on millions of people worldwide [ 11–13 ]. A genome-wide study revealed that a multitude of loci associated with IgAN were related to immune-mediated IBD, intestinal barrier preservation, and gut pathogens reactions [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy

Yan,

Zhao,

Liu

et al. 2024

Renal Failure

View full text Add to dashboard Cite

The mechanisms underlying the complex correlation between immunoglobulin A nephropathy (IgAN) and inflammatory bowel disease (IBD) remain unclear. This study aimed to identify the optimal cross-talk genes, potential pathways, and mutual immune-infiltrating microenvironments between IBD and IgAN to elucidate the linkage between patients with IBD and IgAN. The IgAN and IBD datasets were obtained from the Gene Expression Omnibus (GEO). Three algorithms, CIBERSORTx, ssGSEA, and xCell, were used to evaluate the similarities in the infiltrating microenvironment between the two diseases. Weighted gene co-expression network analysis (WGCNA) was implemented in the IBD dataset to identify the major immune infiltration modules, and the Boruta algorithm, RFE algorithm, and LASSO regression were applied to filter the cross-talk genes. Next, multiple machine learning models were applied to confirm the optimal cross-talk genes. Finally, the relevant findings were validated using histology and immunohistochemistry analysis of IBD mice. Immune infiltration analysis showed no significant differences between IBD and IgAN samples in most immune cells. The three algorithms identified 10 diagnostic genes, MAPK3, NFKB1, FDX1, EPHX2, SYNPO, KDF1, METTL7A, RIDA, HSDL2, and RIPK2; FDX1 and NFKB1 were enhanced in the kidney of IBD mice. Kyoto Encyclopedia of Genes and Genomes analysis showed 15 mutual pathways between the two diseases, with lipid metabolism playing a vital role in the cross-talk. Our findings offer insights into the shared immune mechanisms of IgAN and IBD. These common pathways, diagnostic cross-talk genes, and cell-mediated abnormal immunity may inform further experimental studies.

show abstract

“…IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly manifests in two forms: ulcerative colitis (UC) and Crohn's disease (CD), both of which are characterized by chronic inflammation in the gastrointestinal tract and repeated cycles of relapse and remission. The pathogenesis of IBD appears to be associated with abnormal gut microbiota, environmental changes, gene variants, and immune response dysregulation [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Ca2+-Dependent Processes of Innate Immunity in IBD

Palestra,

Memoli,

Ventrici

et al. 2024

Cells

View full text Add to dashboard Cite

IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly manifests in two forms: ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD appears to be associated with an abnormal response of innate and adaptive immune cells. Innate immunity cells, such as macrophages, mast cells, and granulocytes, can produce proinflammatory (e.g., TNF-α) and oxidative stress (ROS) mediators promoting intestinal damage, and their abnormal responses can induce an imbalance in adaptive immunity, leading to the production of inflammatory cytokines that increase innate immune damage, abate intestinal barrier functions, and aggravate inflammation. Considering that Ca2+ signalling plays a key role in a plethora of cellular functions, this review has the purpose of deepening the potential Ca2+ involvement in IBD pathogenesis.

show abstract

Intestinal Immune Imbalance is an Alarm in the Development of IBD

Cited by 8 publications

References 246 publications

Immune Diseases Associated with Aging: Molecular Mechanisms and Treatment Strategies

Immune Diseases Associated with Aging: Molecular Mechanisms and Treatment Strategies

Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy

Ca2+-Dependent Processes of Innate Immunity in IBD

Contact Info

Product

Resources

About