Intestinal infusion of a liquid diet alters CCK and NPY concentrations in specific brain areas of rats

Della‐Fera, Mary Anne; Koch, James R.; Gingerich, Ronald L.; Baile, Clifton A.

doi:10.1016/0031-9384(90)90338-5

Cited by 10 publications

(1 citation statement)

References 20 publications

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“…Della-Fera et al reported that intestinal infusion of a liquid diet altered CCK and NPY concentration in specific brain areas of rat [10]. Ziotopoulou et al [44] showed that differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice.…”

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confidence: 99%

Effect of Capsaicin on Cholecystokinin and Neuropeptide Y Expressions in the Brain of High-fat Diet Fed Rats

Park

et al. 2004

J. Vet. Med. Sci.

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ABSTRACT. Capsaicin, one of the pungent principles of hot pepper, has been reported to cause a cessation of increases in body weight and fat gain induced by high-fat feeding. Especially, in body weight and feeding control, cholecystokinin (CCK) has been well known as a satiety signal and neuropeptide Y (NPY) has been described as one of the most potent orexigenic signals. This study was carried out to investigate the effect of capsaicin on CCK-and NPY-immunoreactivities (IR) in the brain of high-fat fed rats. The animals were divided into normal-fat diet (NF), high-fat diet (HF) and high-fat diet containing capsaicin (HF-CAP) groups. Mean body weight gain (MBWG) of HF group was higher than that of NF group. However, in HF-CAP group, MBWG was lower than that of HF group. CCK-IR in suprachiasmatic nucleus (SCN), paraventricular nucleus (PVN), median eminence (ME), arcuate nucleus (ARC) and amygdala was not prominent in all the groups. In cerebral cortex, CCK-IR was more reduced in HF-CAP group than in the other groups. In the HF-CAP group, NPY-IR in the hypothalamic nuclei, amygdala and cerebral cortex was more poorly found than in the NF and HF groups. It is concluded that (1) NPY-IR may react more sensitively on capsaicin than CCK-IR, (2) no rapid increase of body weight in cap saicin treated rats may result from the diminished food intake through the low expression of NPY in hypothalamus in HF-CAP group. KEY WORDS: capsaicin, cholecystokinin, high-fat diet, immunohistochemistry, neuropeptide Y.

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confidence: 99%

Effect of Capsaicin on Cholecystokinin and Neuropeptide Y Expressions in the Brain of High-fat Diet Fed Rats

Park

et al. 2004

J. Vet. Med. Sci.

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Neuropeptide Y in Multiple Hypothalamic Sites Controls Eating Behavior, Endocrine, and Autonomic Systems for Body Energy Balance

Stanley¹

1993

The Biology of Neuropeptide Y and Related Peptides

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Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding

Brown¹,

Coscina²

1995

Pharmacology Biochemistry and Behavior

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Intestinal infusion of a liquid diet alters CCK and NPY concentrations in specific brain areas of rats

Cited by 10 publications

References 20 publications

Effect of Capsaicin on Cholecystokinin and Neuropeptide Y Expressions in the Brain of High-fat Diet Fed Rats

Effect of Capsaicin on Cholecystokinin and Neuropeptide Y Expressions in the Brain of High-fat Diet Fed Rats

Neuropeptide Y in Multiple Hypothalamic Sites Controls Eating Behavior, Endocrine, and Autonomic Systems for Body Energy Balance

Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding

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