Intestinal injury can be effectively prevented by Dunaliella salina in gamma irradiated rats

Abstract

Dunaliella salina (D. salina) is one of the most common microalgae that is used as human food. It is isolated from the salty lakes in El-Fayoum and Lake of Bardawil-Sinai in Egypt and can withstand very high concentrations of salt: The potentiality of D. salina , a unicellular biflagellate green alga to protect against intestinal injury induced after radiation exposure was studied. D. salina was given orally in doses of 100 and 200 mg/kg to male Wistar rats for 5 days before exposure to 6 Gray (Gy) gamma radiation and continued for a further two days. Rats were sacrificed 24 h later and intestinal segments were dissected out. One segment was examined histologically and another was used to prepare homogenates to assess relevant biochemical parameters reflecting intestinal injury. Radiation exposure led to a rise in the histological damage score, an increase in tissue tumor necrosis factor (TNF-α), interleukin (IL-1β) and thiobarbituric acid reactive substances (TBARS) but a reduction in tissue reduced glutathione (GSH) and in serum citrulline. Pretreatment with either dose of D. salina effectively reduced the severity of intestinal mucositis induced by gamma radiation.

Disturbances in Thyroid Hormone Metabolism in Rats Exposed to γ- Radiation and Carbon Tetrachloride: The Role of N- acetyl cysteine and Sodium Selenite

“…The inability of the liver to compensate for the imbalance of the redox system leads to the activation of the stress-sensitive signaling pathways or cascades as NF-κB. NF-κB is one of the central regulators in oxidative stressinduced inflammation through upregulation of several pro-inflammatory molecules as TNF-α, IL-1β, IL6, iNOS that culminate into hepatic injury (Alkhaklaf & Khalifa, 2018;Khayyal et al, 2019). The results of the present study indicated an increase in IL-1β associated with NF-κB in rats exposed to radiation and/or CCl 4 .…”

Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF-β and MMP9

“…Group 3: received silymarin (100 mg/kg, orally) [19] daily for 4 weeks after TAA. Groups 4 and 5: received D. salina powder (100 and 200 mg/kg, orally) [20,21] daily for 4 weeks after TAA.…”

Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

“…This anti-inflammatory activity was attributed to the regulation of NF-κB expression. A similar anti-inflammatory effect was produced by D. salina in rats with intestinal injury produced by gamma irradiation [ 96 ]. Moreover, D. salina showed anti-inflammatory effects in rats with diabetic neuropathy induced by streptozotocin [ 46 ] and thioacetamide-induced hepatic encephalopathy [ 52 ].…”