Intestinal insufflation of small volume of oxygen increases systemic oxygenation in acute respiratory distress sуndrome patients

Мазурок, В.А.; Беликов, В Л; Сливин, О А

doi:10.1097/eja.0000000000000146

Cited by 5 publications

(3 citation statements)

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“…Enteral oxygenation has been used in experimental and clinical settings [4][5][6][7][8]. In particular, oxygen has been used as adjunctive therapy for clostridial myonecrosis and necrotizing fasciitis [9].…”

Section: Corresponding Authormentioning

confidence: 99%

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Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Scherbakov¹,

Malisheva²,

Sukhotskaya³

et al. 2022

ait

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Section: Corresponding Authormentioning

confidence: 99%

“…The most desirable goal of enteral oxygen therapy, however, was (and is) to increase systemic oxygenation. In 2015, we published the results of our clinical investigation describing arterial oxygenation improvement following enteral oxygen therapy [ 7 ]. Recently, similar data were obtained by Okabe et al .…”

mentioning

confidence: 99%

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Scherbakov¹,

Malisheva²,

Sukhotskaya³

et al. 2022

ait

Self Cite

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“…Moreover, at the level of systemic administration, it must be considered that oxygen is also re-infused in a venous environment (Figure 1, bottom, different red-blue nuances). The actual role of free oxygen content at the level of the vascular context, and generally at the administration site, is still to be fully studied [43][44][45]. [31].…”

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confidence: 99%

The Biological and Molecular Action of Ozone and Its Derivatives: State-of-the-Art, Enhanced Scenarios, and Quality Insights

Travagli

Iorio

2023

IJMS

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The ultimate objective of this review is to encourage a multi-disciplinary and integrated methodological approach that, starting from the recognition of some current uncertainties, helps to deepen the molecular bases of ozone treatment effects on human and animal well-being and to optimize their performance in terms of reproducibility of results, quality, and safety. In fact, the common therapeutic treatments are normally documented by healthcare professionals’ prescriptions. The same applies to medicinal gases (whose uses are based on their pharmacological effects) that are intended for patients for treatment, diagnostic, or preventive purposes and that have been produced and inspected in accordance with good manufacturing practices and pharmacopoeia monographs. On the contrary, it is the responsibility of healthcare professionals, who thoughtfully choose to use ozone as a medicinal product, to achieve the following objectives: (i) to understand the molecular basis of the mechanism of action; (ii) to adjust the treatment according to the clinical responses obtained in accordance with the principles of precision medicine and personalized therapy; (iii) to ensure all quality standards.

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Exploring alternative routes for oxygen administration

Dyson

Zacchetti

Donati

et al. 2016

ICMx

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BackgroundHypoxemia may compromise cell metabolism and organ function. Supplemental oxygen (O2) at high concentrations may prove ineffective, and issues relating to hyperoxia, barotrauma, mechanical ventilation, and extracorporeal oxygenation are well documented. Old reports suggest the potential safety and efficacy of alternative routes for O2 administration, such as intravenous or intestinal. We re-explored these routes in rat models of hypoxemia.MethodsHypoxemia was induced in spontaneously breathing, anesthetized rats by breathing a hypoxic gas mix (FiO2 0.1). Pilot studies infusing pure O2 gas caused early death, likely due to pulmonary embolism. Instead, rats (n = 6/group) were given intravenous O2 via a continuous infusion of pre-oxygenated Hartmann’s solution (10 ml/kg/h) for 3 h with normal Ringer’s lactate used in control animals. In separate experiments (n = 8/group), bowel intraluminal oxygenation was assessed with pure O2 administered through a cannula placed into the jejunal lumen at a dose of a 15 ml/kg bolus followed by a continuous infusion of 50 ml/kg/h; no treatment was given to controls. Echocardiography, arterial blood gas analysis, mean arterial pressure, muscle and liver tPO2, muscle microvascular perfused vessel density, and urine output were measured.ResultsAdministration of oxygenated Hartmann’s solution (PO2 of solution at end-experiment = 87.5 ± 1.7 kPa) was safe but did not increase either systemic or tissue oxygenation. Similarly, the administration of bowel O2 was safe but did not improve neither systemic nor liver oxygenation.ConclusionsIn this rat model of hypoxemia, the intravenous infusion of gaseous O2 was unfeasible as it induced early mortality. Although safe, both intravenous infusion of oxygenated Hartmann’s solution and bowel O2 administration were unable to improve arterial or tissue oxygenation.

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Intestinal insufflation of small volume of oxygen increases systemic oxygenation in acute respiratory distress sуndrome patients

Cited by 5 publications

References 3 publications

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

Case report of successful treatment of clostridial colitis in a child using enteral oxygen therapy

The Biological and Molecular Action of Ozone and Its Derivatives: State-of-the-Art, Enhanced Scenarios, and Quality Insights

Exploring alternative routes for oxygen administration

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