Background: Intussusception in adult patients is occurred in different reasons. Objectives: The purpose of the present study was to see the spectrum of etiology among adult intussusception patients. Methodology: This case series was performed in the Department of Surgery at Shaheed Suhrawardy Medical College, Dhaka from July 2014 to June 2015 for a period of 1(one) year. All the patients presented with intussusceptions were selected as study population. A detailed history was obtained from each patient. Patients with the age of ≥18 years, regardless the symptoms like onset, duration, intensity, progression were included for this study. Per-operative diagnosis was further confirmed by histopathology of the resected specimen. Result: A total number of 11 cases were recruited after fulfilling the inclusion and exclusion criteria. Gastro intestinal stromal tumour (GIST) was the most common etiology of intussusceptions which was 5(45.5%) cases followed by adenocarcinoma which was 2(18.2%) cases. Meckel"s diverticulum, Intestinal TB, Lipoma and Leiyomyomatous polyp were also found in 1 case each. Conclusion: Adult intussusception is most commonly occurred due to gastro intestinal stromal tumour followed by adenocarcinoma.