Intestinal iron bio-accessibility changes by Lignin and the subsequent impact on cell metabolism and intestinal microbiome communities

Abstract

The detrimental effects of high concentrations of colonic iron have been linked to intestinal inflammation and microbial dysbiosis. Exploiting chelation against this luminal pool of iron may restore intestinal health...

Influence of Dietary Fibre and Protein Fractions on the Trace Element Bioaccessibility of Turnip Tops (Brassica rapa) Growing under Mediterranean Conditions

“…Indeed, this Fe chelating ability has also been associated with other insoluble fibre fractions. Thus, Horniblow et al [53] have recently shown in cell line models (RKO and Caco-2 cells) a significant decrease in intracellular Fe concentration and ferritin expression in the presence of lignin. In our study, we hypothesised that adsorption of Fe to insoluble cellulose also led to insolubilisation of this element in the gastrointestinal model proposed, thus decreasing Fe bioaccessibility.…”

Iron Intake and Human Health

“…While the biopolymeric compound was safe and well tolerated, there were no changes to microbiota populations, and the iron-chelating ability of alginate was presumed to be confounded, possibly by the presence of other dietary chelators in the luminal food matrix content. Further published research by the same authors [ 31 ] showed that another biopolymer compound, namely, lignin, chelated iron and restricted its availability to detrimental proteobacteria while promoting the growth of favored beneficial bacteroides. Hence, lignin could be used to control microbial dysbiosis and inflammation associated with gut disorders.…”