Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle seeds than their oil

Opyd, Paulina M.; Jurgoński, Adam

doi:10.1038/s41598-021-00397-1

Cited by 8 publications

(13 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SCFAs, mainly acetate, propionate and butyrate, are the major end products of dietary fibre fermentation in the distal intestine, and they are considered indirect nutrients for the body [ 29 ]. Interestingly, milk thistle fibre was well fermented to propionate at the expense of acetate, which confirmed previous findings of increased propionate production from milk thistle fibre in the distal gut of genetically obese rats [ 23 ]. Propionate fermentation is especially important, because after absorption into the bloodstream, this acid reaches the liver, thus decreasing lipogenesis [ 30 ].…”

Section: Discussionsupporting

confidence: 89%

“…MTSs also contained a considerable amount of fat (25%), whereas PMSs had significantly less fat (10%). Additional details on the chemical composition of MTSs used in the present study have been previously reported [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, dietary MTSs only lowered plasma triglyceride levels (vs. the FR + PMS group), which may have been partly due to their lipid fraction (25% seeds), including linoleic acid, and/or intensified propionate production in the distal intestine ( Table 3 ). Silymarin found in MTSs is known as a cholesterol-lowering factor rather than a triglyceride-lowering factor [ 23 , 25 ]. In the present study, dietary PMSs unfavourably affected the function of internal organs, as indicated by enlarged liver and kidneys after 4 weeks of feeding, and these changes were accompanied by increased ALT, AST and ALP activities, as well as blood urea concentration ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Asteraceae Seeds as Alternative Ingredients in a Fibre-Rich Diet: Protein Quality and Metabolic Effects in Rats

Koza

Jurgoński

2023

Molecules

Self Cite

View full text Add to dashboard Cite

We verified whether milk thistle seeds and pot marigold seeds provided valuable components for a fibre-rich diet and how their addition affected body composition, nitrogen balance and lipid metabolism in rats. Growing rats were fed a control diet (5% fibre) or three fibre-rich diets (24% fibre), which contained cellulose as the sole source of fibre (24%; positive control), milk thistle seeds (32%) or pot marigold seeds (39%). All diets were balanced in macronutrients, including total protein content (9%), which was half of the amount recommended for rats to maximise protein absorption and utilisation, and the ratio of plant protein to animal protein (approx. 1:1). After 4 weeks, dietary pot marigold seeds reduced body weight gain, which translated into lower gains of body fat and lean mass in rats (all at p ≤ 0.05). Protein digestibility differed among individual fibre-rich diets (p ≤ 0.05), with the lowest result having been recorded for dietary pot marigold seeds (73%), followed by dietary milk thistle seeds (78%), and the highest result having been recorded for dietary soybean protein isolate (control protein source, 89%). Nitrogen retention was higher with dietary soybean protein isolate (53%) and dietary milk thistle seeds (47%) than with dietary pot marigold seeds (38%) (p ≤ 0.05). In the caecal digesta, the concentrations of the major short-chain fatty acids were almost or >2-fold higher after dietary milk thistle seeds and pot marigold seeds than after the positive control diet (all at p ≤ 0.05). Dietary pot marigold seeds enlarged the liver and increased the plasma activities of liver enzymes but reduced hepatic lipid contents (all at p ≤ 0.05). Certain Asteraceae seeds provide components of varied nutritional quality, with milk thistle seeds being a relatively good source of protein and both types of seeds being a source of fermentable fibre. Pot marigold seeds have potential anti-obesogenic effects, but with the risk of damaging internal organs.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Asteraceae Seeds as Alternative Ingredients in a Fibre-Rich Diet: Protein Quality and Metabolic Effects in Rats

Koza

Jurgoński

2023

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…oleic acid), phytosterols, alpha tocopherol, quercitin, histamine, tannins, minerals and vitamins. 2,7,18,26…”

Section: Substances Contained In Milk Thistlementioning

confidence: 99%

“Silybum marianum” – properties and application in medicine – a review

Sowińska¹,

Szpunar²

2022

Eur J Clin Exp Med

View full text Add to dashboard Cite

Introduction and aim. The subject of this article is milk thistle – a plant belonging to the Asteraceae family. Due to its properties, it has a beneficial effect on the functioning of important organs and systems of the human body. The aim of this paper was to review information on milk thistle, its use in medicine and the description of some of the chemical compounds due to which it owes its healing properties. Material and methods. The article is a review of the publicly available literature on milk thistle, the chemical composition of its compounds and its use in medicine. Analysis of the literature. Current information about “Silybum marianum” is presented. Conclusion. Milk thistle is a valuable medicinal plant due to the presence of numerous antioxidant and anti-inflammatory compounds. The benefits of supplementation with ingredients derived from milk thistle, their negligible interaction with other drugs and the lack of significant side effects, known so far, indicate that the plant described in the article can be a good medicine and a preventive measure against diseases affecting our society.

show abstract

“…Opyd and Jurgoński (2021) studied the impact of MSTO supplementation on liver disorders in genetically obese rats [7].…”

Section: Introductionmentioning

confidence: 99%

Biological <i>in Vitro</i> and <i>in Vivo</i> Studies of the Milk Thistle Seed Oil

Gaber¹,

Sedki²,

Sherbiny³

et al. 2022

FNS

View full text Add to dashboard Cite

The milk thistle plant is one of the famous plants that have been gaining popularity for its therapeutic potential for centuries. Milk thistle seed oil (MTSO) has been subjected to extensive research. The fixed oil was extracted from the seeds of Silybum marianum (L.) using petroleum ether as a solvent by a soxhlet device. GC-MS was used to identify the chemical composition of the oil. The antioxidant activity of MTSO was tested by the ABTS method, which showed the ability to inhibit lipid peroxidation. In addition, antimicrobial and antifungal investigations were examined. It proved that MTSO has an inhibitory effect against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and antifungal effects (Candida albicans). MTSO has a slightly higher effectiveness against fungi than bacteria.Moreover, the cytotoxic activities of the oil on hepatocellular and colorectal carcinoma were examined. MTSO has shown a moderate cytotoxic effect on the HCT-116 cell line and a weak effect on HePG-2. Whereas; in vivo study has been done on five diagnosed patients who have impaired liver function, and were recruited for the study. Their weight ranged from 100 ± 30 kg, their age range was between 39 -50 years. Each patient was given ten drops of MTSO daily and added to a little water for a four-week study period. MTSO has effects to improve the function of the injured liver. The present work aims to study Milk thistle seed oil, for estimating its pharmacological properties for the liver. This study focused on showing the importance of milk thistle seed oil in our lives as a source of antioxidants, anti-bacterial and anti-fungal, and as an anti-cancer of the liver and colon. It also sheds light on its importance as a treatment for impaired liver, function and fatty liver, due to its improvement in all liver function markers, so it can be hired as an effective human therapy.

show abstract

Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle seeds than their oil

Cited by 8 publications

References 53 publications

Asteraceae Seeds as Alternative Ingredients in a Fibre-Rich Diet: Protein Quality and Metabolic Effects in Rats

Asteraceae Seeds as Alternative Ingredients in a Fibre-Rich Diet: Protein Quality and Metabolic Effects in Rats

“Silybum marianum” – properties and application in medicine – a review

Biological <i>in Vitro</i> and <i>in Vivo</i> Studies of the Milk Thistle Seed Oil

Contact Info

Product

Resources

About

Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle seeds than their oil

Cited by 8 publications

References 53 publications

Asteraceae Seeds as Alternative Ingredients in a Fibre-Rich Diet: Protein Quality and Metabolic Effects in Rats

Asteraceae Seeds as Alternative Ingredients in a Fibre-Rich Diet: Protein Quality and Metabolic Effects in Rats

“Silybum marianum” – properties and application in medicine – a review

Biological &lt;i&gt;in Vitro&lt;/i&gt; and &lt;i&gt;in Vivo&lt;/i&gt; Studies of the Milk Thistle Seed Oil

Contact Info

Product

Resources

About

Biological <i>in Vitro</i> and <i>in Vivo</i> Studies of the Milk Thistle Seed Oil