Intestinal lymphoid nodular hyperplasia in children: The relationship to food allergy

Abstract

Intestinal LNH should be considered a benign finding in children without red flags, because the symptoms are largely self-limiting. The use of mesalamine or elimination diet does not modify the clinical outcome compared to symptomatic therapy. The presence of food allergy was not predicted by allergy skin testing and was found in a minority of patients.

Dietary Patterns and Interventions to Alleviate Chronic Pain

“…Patients were followed-up 24 months. Clinical improvement was observed in all patients, without a specific effect of mesalamine or of the elimination diet compared to symptomatic treatment [57].…”

Ileocolonic Lymphonodular Hyperplasia in Children Related to Etiologies Ranging from Food Hypersensitivity to Familial Mediterranean Fever

“…Gurkan et al [11] reported that LNH was found 12.6% in children who underwent colonoscopy. Lucarelli et al [17] reported an increased ratio in Italian children, i.e., 36%. In previous studies, the frequency of LNH varied between 10 and 30%, with variation depending on the terminal ileum intubation, colonoscopy indications, and study design (e.g., including only isolated LNH) [10].…”

“…Lucarelli et al [17] reported a weak association between LNH and FH. They divided the isolated LNH patients into 3 groups randomly: an elimination diet group (cow’s milk, eggs, and foods positive on skin prick tests), a mesalamine group, and a symptomatic treatment group.…”

Hiperplasia nodular linfoide de colon en niños: ¿un hallazgo normal o una condición patológica subestimada?

“…Puesto que por razones éticas no se practicaron las colonoscopias de control en pacientes con mejoría clínica, no es posible establecer si existió erradicación de la hiperplasia nodular linfoide posterior al tratamiento. 55 Se carece de estudios que evalúen la administración de salicilatos por vía rectal, que pareciera ser más lógico en pacientes con afección anorrectal o colónica.…”