Intestinal melanoma: A broad spectrum of clinical presentation

Patti, Rosalia; Cacciatori, Matilde; Guercio, Giovanni; Territo, Valentina; Vita, Gaetano Di

doi:10.1016/j.ijscr.2012.03.033

Cited by 32 publications

(34 citation statements)

References 16 publications

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“…The polypoid pattern is the one most commonly found in small bowel metastasis [2,10,11] which is also true in our case and that may be the reason why the patient developed intussusception; the polypoid lesion acting as lead point.…”

Section: Discussionsupporting

confidence: 74%

“…The failure to detect metastasis is due to lack of specific symptoms early in the disease or they are asymptomatic [9]. Sometimes, small bowel melanoma presents with emergency clinical picture due to intestinal obstruction or intestinal intussusception and rarely as bowel perforation [2]. In a review of 13 pathologic specimen of intussusception, lipoma was the most common benign tumor and metastatic malignant melanoma was the most common malignant tumor [10].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection allows getting the final pathologic diagnosis. It is also reported that surgical intervention increased survival significantly; especially when resection is complete on microscopic examination [2,12].…”

Section: Discussionmentioning

confidence: 99%

“…Gastrointestinal tract malignant melanomas are rare form of neoplasm that may be either primary or metastatic. Small bowel metastatic deposits attributed to malignant melanoma originating from skin primary are found in 2-5% of patients [2]. The melanoma of the small bowel is often asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

“…The melanoma of the small bowel is often asymptomatic. If symptoms are present they are usually nonspecific and can vary from abdominal pain (17 -64%), occult or gross bleeding (24 -84%) and weight loss (10 -47%) [2]. Diagnosis is often delayed until the illness complicated and become an emergency, such as intestinal hemorrhage, obstruction and perforation [3].…”

Section: Introductionmentioning

confidence: 99%

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Ileo-ileal intussusception due to small bowel melanoma

Muleta¹,

Abdisa²,

Berhane³

2016

Arch Clin Cases

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Gastrointestinal tract malignant melanoma is an uncommon form of neoplasm that may be either primary or metastatic. Diagnosis is often delayed until the illness becomes an emergency due to complications, such as intestinal hemorrhage, obstruction and perforation. We report a case of 42 year-old Ethiopian male patient presented to the emergency department with sign and symptoms of intestinal obstruction. The patient underwent laparotomy, ileo-ileal intussusception reduced and small bowel mass resection done. The histopathologic examination confirmed malignant small bowel melanoma. The purpose of this case report is to discuss clinical presentation and pathologic features of this rare condition with a review of the current literature.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ileo-ileal intussusception due to small bowel melanoma

Muleta¹,

Abdisa²,

Berhane³

2016

Arch Clin Cases

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Management of intussusception in patients with melanoma

Perez

Sun

Farley

et al. 2019

Journal of Surgical Oncology

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Background Increased cross‐sectional imaging for surveillance of metastatic melanoma has led to more diagnoses of asymptomatic intussusception. Methods We performed a multi‐institutional retrospective review of patient records with a history of metastatic melanoma and a diagnosis of intussusception. Patients were divided into three groups: 1) asymptomatic patients without current evidence of melanoma (no evidence of disease [NED]); 2) asymptomatic intussusception and known active metastatic melanoma; 3) symptomatic intussusception and known active metastatic melanoma; the number of patients requiring surgery and intraoperative findings were recorded. Results We reviewed 73 patients diagnosed with intussusception from 2004 to 2017. Among asymptomatic patients with NED (n = 16), 14 spontaneously resolved and 2 underwent pre‐emptive surgery without abnormal intraoperative findings. Of asymptomatic patients with active metastatic disease (n = 32), 25 were initially observed and 7 underwent pre‐emptive surgery and 9 of the 25 initially observed patients required surgery for development of symptoms. In this group, all 16 patients undergoing surgery (50% of the group) had intraoperative findings of intussusception and/or metastatic intestinal melanoma.. All symptomatic patients with metastatic melanoma (n = 25) underwent surgery; all had intraoperative findings of intussusception and/or metastatic melanoma except 1 (Meckel's diverticulum). Conclusion Asymptomatic patients with NED do not require surgery and intussusception will likely resolve spontaneously. Asymptomatic patients with known metastatic melanoma may be initially observed, but a low threshold for surgery should be maintained. Symptomatic patients with known metastases should undergo surgery.

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Metastatic Melanoma to the Small Bowel and Colon: A Systematic Review of the Global Experience and Institutional Cohort Analysis Detailing a Rare Clinical Entity

Yee,

Thielen,

Truong

et al. 2024

Journal of Surgical Oncology

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IntroductionCutaneous melanoma is among the most common solid tumors to metastasize to the gastrointestinal (GI) tract. Literature summarizing the clinical experience and features of this unique pathology is lacking.MethodsA systematic review of the available literature reporting clinically salient features of melanoma metastases to the small and large intestines was conducted. Additionally, we surveyed our institutional experience of surgically treated melanoma metastasis to the small bowel and colon. A descriptive analysis was performed. Kaplan–Meier curves with log‐rank tests were used to analyze time‐to‐event intervals. Univariable and multivariable Cox logistic regression models were generated to identify predictors of survival.ResultsOver 100 studies including 1153 patients were included. GI metastases predominantly affected males, were in the small bowel/jejunum, equally presented as solitary and multiple lesions, and were generally not the first site of distant metastatic disease. The median time from primary lesion diagnosis to GI metastasis was 48 months. Analysis of our institutional cohort suggested that survival in patients receiving complete GI‐specific surgical resection and immune checkpoint inhibitors (ICIs) was prolonged compared to palliative resection and without ICI therapy. Positive prognostic factors for survival following GI metastasis included fewer GI metastatic lesions, complete resection, and longer duration between primary tumor diagnosis and GI metastasis.ConclusionsGI metastases are a sign of advanced metastatic melanoma. Clinical suspicion of metastatic involvement in patients with a history of melanoma who develop any abdominal symptoms or anemia should remain high. Receipt of complete surgical resection and ICIs may prolong survival in disseminated melanoma.

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Intestinal melanoma: A broad spectrum of clinical presentation

Abstract: Small bowel melanoma is rare and the diagnosis done late. Imaging techniques are recommended in order to obtain early diagnosis of gastrointestinal metastases.

Cited by 32 publications

References 16 publications

Ileo-ileal intussusception due to small bowel melanoma

Ileo-ileal intussusception due to small bowel melanoma

Management of intussusception in patients with melanoma

Metastatic Melanoma to the Small Bowel and Colon: A Systematic Review of the Global Experience and Institutional Cohort Analysis Detailing a Rare Clinical Entity

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