Intestinal Microbes and Hematological Malignancies

Abstract

Hematological malignancies are diverse, with high malignancy characteristics, poor prognoses, and high mortality rates. The development of hematological malignancies is driven by genetic factors, tumor microenvironment factors, or metabolic factors; however, even when considering all of these factors, one still cannot fully estimate the risk of hematological malignancies. Several recent studies have demonstrated an intimate connection between intestinal microbes and the progression of hematological malignancies, and gut microbes play a primary role in the initiation and progression of hematological tumors through direct and indirect mechanisms. Thus, we summarize the correlation between intestinal microbes and hematological malignancies’ onset, progression, and therapeutic effect in order to better understand how intestinal microbes affect their initiation and progression, especially in leukemia, lymphoma, and multiple myeloma, which may provide potential therapeutic targets for improving the survival of patients with hematological malignancies.

Probióticos No Tratamento Do Mieloma Múltiplo: Uma Revisão

“…Vários fatores podem contribuir para o surgimento desses tumores, incluindo genética, ambiente, dieta e microbioma. No entanto, esses fatores também podem afetar os micróbios intestinais, resultando em diferenças entre os pacientes com tumores (Zhu et al, 2023). No contexto do mieloma múltiplo (MM), a microbiota intestinal desempenha um papel crucial na modulação da imunidade do câncer e nos resultados do tratamento (Lu et al, 2021).…”