Intestinal mucosal oxidative damage and bacterial translocation in cirrhotic rats

Chiva, M.; Guarner, Carlos; Peralta, Carmen; Llovet, Teresa; Gómez, G.; Soriano, Germán; Balanzó, J.

doi:10.1097/00042737-200302000-00007

Cited by 77 publications

(43 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this regard, increased circulating IgA and IgAIC may represent an exaggerated response of immune system to excess gut antigen exposure [34,35] , resulting from diminished mucosal integrity and spillage of IgA into the circulation. Another mechanism could involve the endotoxemia that frequently accompanies LC with PH [36] , suggested to be generated by gut flora through bacterial translocation [37,38] favored by dysfunction of intestinal barrier [33,37] . Previous literature showed that endotoxemia may decrease hepatic ASGR binding [39] .…”

Section: Discussionmentioning

confidence: 99%

Association of liver cirrhosis related IgA nephropathy with portal hypertension

Kalambokis

Christou²,

Stefanou³

et al. 2007

WJG

View full text Add to dashboard Cite

A high incidence of IgA nephropathy has been reported in patients with liver cirrhosis, though, clinically evident nephrotic syndrome is very uncommon. Impaired hepatic clearance of circulating IgA immune complexes and subsequent deposition in renal glomeruli has been considered principally in the pathogenesis of liver cirrhosis associated IgA nephropathy. Here we report on a patient with cryptogenic liver cirrhosis and splenic vein thrombosis, who presented with nephrotic syndrome. Renal biopsy showed findings consistent with IgA nephropathy. Lower endoscopy showed features of portal hypertensive colopathy. Following initiation of propranolol and anticoagulant treatment to reduce portal pressure, a gradual decrease of proteinuria and hematuria to normal range was noted. The potential p a t h o g e n e t i c ro l e o f p o r t a l hy p e r t e n s i o n i n t h e development of IgA nephropathy in cirrhotic patients is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of liver cirrhosis related IgA nephropathy with portal hypertension

Kalambokis

Christou²,

Stefanou³

et al. 2007

WJG

View full text Add to dashboard Cite

show abstract

“…However, other aspects are still subject to investigation such as its pathogenesis [12] , diagnosis [13] and prevention [14] . Although most episodes of SBP occur in patients with advanced cirrhosis with ascites, occasionally it has been observed in non-cirrhotic patients such as fulminant hepatic failure [15] , nephrotic syndrome [16] and congestive heart failure [17] .…”

Section: Discussionmentioning

confidence: 99%

Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran

Haghighat

Dehghani

Alborzi³

et al. 2006

WJG

View full text Add to dashboard Cite

INTRODUCTIONSpontaneous bacterial peritonitis (SBP) is defined as an ascitic fluid infection without a demonstrable intraabdominal cause [1] . It is a well known complication of cirrhosis in adults, occurring in 8% to 13% of patients [2][3][4][5] . The diagnosis is established by a positive ascitic fluid bacterial culture and an elevated ascitic fluid absolute polymorphonuclear leukocyte (PMN) count (≥ 2.5 × 10 5 /L). In adults, the organisms of SBP are usually gramnegative bacteria [2][3][4]6] , but they may differ in children [5,7] . The aim of the present study was to deter mine the causative agents of SBP in children with liver disease and ascites in our center. MATERIALS AND METHODSDuring a period of 2.5 years, from September 2003 to March 2006, 63 children with liver disease and ascites were prospectively studied in the Department of Pediatric Gastroenterology in Nemazee Hospital affiliated with Shiraz University of Medical Sciences, the major referral center in Southern Iran. Written consent was obtained from all parents after informing them about this study which was approved by the Ethics Committee of the University.Of the children involved in this study 12 had met the criteria for SBP (polymorphonuclear leukocyte count greater than 2.5 × 10 5 /L and positive ascitic fluid culture). In total 13 episodes of SBP were documented, of which two occurred with one patient, 4 mo apart. The patients and their parents answered a structured questionnaire, which included name, age, sex, clinical history, underlying liver diseases, history of antibiotic and diuretic use, history of previous variceal bleeding and episodes of SBP. All children had undergone a thorough physical examination.Serum albumin and glucose, urinalysis and urine culture were done in all patients. CONCLUSION: S. pneumoniae is the most common cause of SBP in the pediatric age group and we recommend a third generation cephalosporine (e.g., Ceftriaxione or Cefotaxime) for empirical therapy in children with SBP.

show abstract

“…It is a factor contributing to the damage of the intestinal mucosa (enabling thus BT) as well as to the development of oesophageal varices. We selected the spleen to body weight ratio of the experimental animal as a parameter suitable for the evaluation of portal hypertension (Oren et al, 1999;Dasarathy et al, 2002;Chiva et al, 2003). Chiva et al (2003) found that the values of the spleen to body weight ratio of the experimental animal in laboratory rats with liver cirrhosis caused by the application of tetrachloromethane were quite comparable with ours.…”

Section: Discussionmentioning

confidence: 60%

Influence of the Escherichia coli Nissle 1917 strain on complications of the chronic experimental liver damage

Kosáková¹,

Scheer²,

Lata³

et al. 2007

Vet. Med.

View full text Add to dashboard Cite

ABSTRACT:The aim of the study was evaluate the influence of the probiotic Escherichia coli Nissle 1917 strain (Mutaflor ® suspension, Ardeypharm GmbH, Herdecke, Germany) on bacterial translocation in cases of liver damage, damage to the intestinal mucosa, potential portal hypertension associated with possible development of oesophageal varices and on the bacterial population of the intestine during chronic experimental liver damage in the laboratory rat. Rats with liver damage induced by thioacetamide were divided into an experimental and control group. Experimental and control animals were applied Mutaflor and saline, respectively. Samples of blood, liver, lymph nodes and caecum for microbiological examination, of liver, duodenum and oesophagus for histological examination and of spleen for weight evaluation were collected. There were no significant differences between both groups of animals in the qualitative proportion of Staphylococcus spp., Enterococcus spp. and Proteus spp. cultured from the lymph nodes, blood and liver. The quantitative culture results on Enterococcus spp. in the caecum, liver and lymph nodes showed no significant differences between both groups. There was a significant difference between the experimental and control group in the counts of coliform bacteria. No significant differences between both groups were found in the overall damage score of the liver, duodenum and oesophagus. There were no differences in the spleen to body weight ratio of both groups. The application of Mutaflor ® suspension for eight days had no recognisable effect diminishing the selected complications of chronic liver damage caused by the administration of TAA to laboratory rats.

show abstract

Intestinal mucosal oxidative damage and bacterial translocation in cirrhotic rats

Abstract: Cirrhotic rats, particularly those with ascites and bacterial translocation, show increased malondialdehyde levels in ileal and caecal mucosa. These results suggest that mucosal oxidative damage in ileum and caecum could favour bacterial translocation in cirrhotic rats.

Cited by 77 publications

References 21 publications

Association of liver cirrhosis related IgA nephropathy with portal hypertension

Association of liver cirrhosis related IgA nephropathy with portal hypertension

Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran

Influence of the Escherichia coli Nissle 1917 strain on complications of the chronic experimental liver damage

Contact Info

Product

Resources

About