Intestinal Obstruction and Mucoviscidosis

Intestinal obstruction in an adult suffering from mucoviscidosis

“…In this particular case, although a laparotomy was performed, medical treatment as described was instituted, and the patient recovered. However, operative findings agreed with the previously presented pictures of firmly adherent, viscid, putty-like material in the bowel (Mullins and others, 1965;Beck and Aterman, 1966 increased. This could be due to increasing damage to the pancreas as the disease progresses, so that, following the destruction of the pancreatic acini, the islets of Langerhans also become involved (Powell, 1968).…”

“…I t has all the features described in the triad of mucoviscidosis (Batten, 1965) : the patient had nasal polypi removed as a teenager (Goodman, 1967) ; he developed diabetes mellitus later (Anderson and others, 1965)~ and finally presented in adult life, not with respiratory complications (Anderson and others, 1965)~ but with intestinal obstruction (Faconi, 1960;Mullins and others, 1965). Mullins and others (1965)~ then Beck and Aterman (1966)~ laid great stress on diagnosis as a preliminary to treatment, since it is possible to treat these cases medically with success (Table I ) . In this particular case, although a laparotomy was performed, medical treatment as described was instituted, and the patient recovered.…”

“…This so-called 'meconium ileus' occurs in 5-10 per cent of all infants with mucoviscidosis and almost invariably requires surgical relief of the obstruction, But as more infants survive because of their improved treatment, there is an increased likelihood of adults suffering from mucoviscidosis presenting, not with respiratory complications (Anderson, Laszlo, and Brown, 1965), but as the surgical emergency of intestinal obstruction (Fanconi, * Now Surgical Registrar at the Sutton General Hospital, Sutton, Surrey. Mullins, Talamo, and di Sant Agnese, 1965; Beck and Aterman, 1966).…”

Intussusceptions arising from two different sites in a child with cystic fibrosis

“…5,15,16 Intussusception complicates distal intestinal obstruction syndrome, whereby a tenacious fecal bolus adheres to the mucosa and may act as a lead point. 11,[17][18][19] Another frequent cause for lead points in patients with CF is the appendix, [20][21][22][23][24][25][26] which is often large and distended due to inspissated mucofeculant contents, as in our case. However, it was felt that distal intestinal obstruction syndrome rather than the appendix explained the occurrence of the initial findings, as ultrasound and air enema identified a colo-colic rather than ileo-colic intussusception.…”

Light and Electron Microscopical Studies of Rectal Biopsies in Cystic Fibrosis

“…(Thomadis et al 1963). Intestinal obstruction in patients with c. f. of varying ages has been reported (Beck et al 1966)) and has been described as meconium ileus Equivalent (m. i. E.) ( J~n s m 1962).…”