Intestinal parasites of conventionally maintained BALB/c mice and <i>Mastomys coucha</i> and the effects of a concomitant schistosome infection

Higgins-Opitz, Susan B.; Dettman, C. D.; Dingle, C.E.; Anderson, Celia B.; Becker, P J

doi:10.1258/002367790780866137

Cited by 10 publications

(4 citation statements)

References 10 publications

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“…In the comparison of the present results with those reported by Gonçalves et al (1998) referring to worm burdens, inbred mice investigated here, harbored smaller parasite loads and are in accordance with Higgins-Opitz et al (1990) and Moulia et al (1995) that refer to lower prevalences of S. obvelata in inbred mice strains.…”

Section: Discussionsupporting

confidence: 91%

Patterns of infection with the nematodes Syphacia obvelata and Aspiculuris tetraptera in conventionally maintained laboratory mice

Bazzano¹,

Restel²,

Pinto

et al. 2002

Mem. Inst. Oswaldo Cruz

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Data on the frequency, distribution and mean intensity of the helminth fauna recovered from outbred and inbredLaboratory animals are suitable and necessary for the proper development of several biological assays. The utilization of these standard models is recommended aiming at the attainment of reliable and reproductible results. In despite of this approach, laboratory animals are seldom investigated for autochthonous ecto and endoparasites prior to their utilization in experiments. In conventional, semi-open facilities, rodent colonies are frequently infected with helminths. These parasites, if undetected, can interfere in the development of protocols and alter the interpretation of final results (Pinto et

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Section: Discussionsupporting

confidence: 91%

Patterns of infection with the nematodes Syphacia obvelata and Aspiculuris tetraptera in conventionally maintained laboratory mice

Bazzano¹,

Restel²,

Pinto

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…There are several references to the occurrence of interactions between infection with other parasites and S. mansoni, both in experimental models and in humans, showing negative or positive interactions 8,15,19,24,27 . In this study mice coinfected with T. canis -S.mansoni showed in the 23 rd and 70 th days after infection, lower production of anti-Toxocara antibodies when compared to the group infected only by the ascarid (Fig.…”

Section: Savigny Et Al (1979)mentioning

confidence: 99%

IgG Antibody responses in mice coinfected with Toxocara canis and other helminths or protozoan parasites

Lescano

Nakhle

Ribeiro³

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe immune response expressed by IgG antibodies in BALB/c mice experimentally infected with Toxocara canis, was studied with the aim of verifying the possible in vivo cross-reactivity between antigens of T. canis and other parasites (Ascaris suum, Taenia crassiceps, Schistosoma mansoni, Strongyloides venezuelensis and Toxoplasma gondii). Experiments included three groups of mice: one infected only by T. canis, another with one of the other species of parasites and a third concomitantly infected with T. canis and the other species in question. Animals were bled by orbital plexus at 23, 38 and 70 days post infection (p.i.). Sera were analyzed for anti-Toxocara antibodies by ELISA and Immunoblotting, using excretion-secretion antigens (ES), obtained from culture of thirdstage larvae of T. canis. For all experiments a control group comprised by ten non-infected mice was used. Only in the case of A. suum infection, in these experimental conditions, the occurrence of cross-reactivity with T. canis was observed. However, in the case of co-infection of T. canis -S. mansoni, T. canis -S. venezuelensis and T. canis -T. crassiceps the production of anti-Toxocara antibodies was found at levels significantly lower than those found in mice infected with T. canis only. Co-infection with S. mansoni or S. venezuelensis showed lower mortality rates compared to what occurred in the animals with single infections. Results obtained in mice infected with T. canis and T. gondii showed significant differences between the mean levels of the optical densities of animals infected with T. canis and concomitantly infected with the protozoan only in the 23 rd day p.i.

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“…For example, BALB/c mice with concomitant schistosome infection have significantly increased prevalences of T. muris, since the immunological changes may alter the susceptibilities of the host to the parasite [9]. In the present study, some of the proteins affected by the infection were related to immune response (Fig.…”

mentioning

confidence: 58%

Effects of Tritrichomonas muris on the Mouse Intestine: A Proteomic Analysis

et al. 2009

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Abstract:Although Tritrichomonas muris is a common parasite often detected in experimental animals including mice, its pathogenesis in host animals remains unclear. Proteomics can be used to specifically analyze biochemical host-parasite interaction and immune responses of the host to parasites. However, proteomics have not yet been applied to T. muris studies. Here, the effects of T. muris on the host were analyzed by proteomics. We found that 10 different proteins were expressed in T. muris-infected mice intestines compared with noninfected intestines. The identified proteins represented several functions mainly related to stress, immune response, metabolism and signal transduction. The results suggest that T. muris infection may affect processes that are acclimatizing to the environmental changes caused by the infection in the mouse intestine.

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Intestinal parasites of conventionally maintained BALB/c mice and Mastomys coucha and the effects of a concomitant schistosome infection

Cited by 10 publications

References 10 publications

Patterns of infection with the nematodes Syphacia obvelata and Aspiculuris tetraptera in conventionally maintained laboratory mice

Patterns of infection with the nematodes Syphacia obvelata and Aspiculuris tetraptera in conventionally maintained laboratory mice

IgG Antibody responses in mice coinfected with Toxocara canis and other helminths or protozoan parasites

Effects of Tritrichomonas muris on the Mouse Intestine: A Proteomic Analysis

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