Intestinal parasitosis and associated factors among diabetic patients attending Arba Minch Hospital, Southern Ethiopia

Alemu, Getaneh; Abdu, Jemal; Zerdo, Zerihun

doi:10.1186/s13104-018-3791-x

Cited by 14 publications

(13 citation statements)

References 10 publications

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“…Besides, individuals from rural areas are more likely to be engaged in farming and domestic work which exposes them to these intestinal parasite infections. However, this result differed from the findings reported in Arba Minch, Ethiopia, where the prevalence of parasitic infections was higher from the urban areas 33 (15.3%) than in rural areas 9 (4.2%) [ 15 ]. This might be due to the difference in hygiene and sanitation usage in these two particular areas and could be due to the migration of DM patients from rural to urban areas so that overpopulation can result in a high prevalence of intestinal parasites [ 11 , 16 ].…”

Section: Discussioncontrasting

confidence: 90%

The Prevalence of Intestinal Parasites and Their Associated Factors among Diabetes Mellitus Patients at the University of Gondar Referral Hospital, Northwest Ethiopia

Ambachew

Assefa

Tegegne

et al. 2020

Journal of Parasitology Research

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Background. Worldwide, more than one-sixth of the population is infected by intestinal parasites, of which the majority live in developing countries. On the other hand, the prevalence of diabetes mellitus has been increasing over recent decades in developing countries. Patients with diabetes mellitus encountered impaired immunity and suffer from the consequences of infection particularly intestinal parasitic infection. Objective. This study is aimed at assessing the prevalence of intestinal parasites and associated factors among diabetes mellitus patients at the University of Gondar Referral Hospital, Northwest Ethiopia. Methods and Materials. An institutional-based cross-sectional study was conducted at the University of Gondar Comprehensive Specialized Referral Hospital from February 15 to March 30, 2018. A total of 234 diabetes mellitus patients were enrolled. A systematic random sampling technique was used to select study participants. Sociodemographic and clinical data were collected using a semistructured questionnaire. A 5-gram stool sample was collected to identify parasitic infection using a direct wet mount and formal-ether concentration technique. Data was entered and analyzed by using SPSS version 20. A p value of ≤0.05 was considered as statistically significant. Result. In the current study, the overall prevalence of intestinal parasite infection among diabetics was 45 (19.2%). The parasites identified in this study were Ascaris lumbricoides 15 (6.41%), Entamoeba histolytica/dispar 9 (3.85%), Hookworm 9 (3.85%), Schistosoma mansoni 7 (3%), Enterobius vermicularis 3 (1.3%), and Giardia lamblia 2 (0.9%). Poor educational background ( AOR = 3.62 ; 95% CI (1.038, 12.65); p = 0.043 ), poor hygiene and sanitation ( AOR = 4.67 ; 95% CI (1.82, 12.07); p = 0.001 ), and inappropriate latrine usage ( AOR = 5.41 ; 95% CI (1.43, 20.56); p = 0.013 ) were significantly associated with the prevalence of intestinal parasitic infection among diabetes mellitus patients. Conclusion. The overall prevalence of intestinal parasitic infection among diabetes mellitus patients was relatively high. There should be continued prevention, control, and management of intestinal parasitic infection in such a study population.

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Section: Discussioncontrasting

confidence: 90%

The Prevalence of Intestinal Parasites and Their Associated Factors among Diabetes Mellitus Patients at the University of Gondar Referral Hospital, Northwest Ethiopia

Ambachew

Assefa

Tegegne

et al. 2020

Journal of Parasitology Research

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“…Current evidence about the relationship between pathophysiological mechanisms of diabetes and COVID-19 are limited and further research is still needed. (280,282,283), and Giardia lamblia (283). Interestingly, diabetic patients who were treated with metformin had less P. falciparum infections compared to untreated patients (276).…”

Section: Coronaviruses (Cov)mentioning

confidence: 99%

“…Patients with T2DM have an elevated risk of infection with Plasmodium falciparum ( 276 ), Toxoplasma gondii ( 277 ), Opisthorchis viverrini ( 278 ), Strongyloides stercoralis ( 279 ), Cryptosporidium parvum ( 280 ), Blastocystis hominis ( 281 ), Ascaris lumbricoides ( 280 , 282 , 283 ), and Giardia lamblia ( 283 ). Interestingly, diabetic patients who were treated with metformin had less P. falciparum infections compared to untreated patients ( 276 ).…”

Section: Effects Of T2dm On the Susceptibility Of Patients To Infectimentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro-and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.

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“…Intestinal parasites and diabetes have been constantly evaluated, mainly due to the possibility of immune dysfunction in diabetes allowing the development of more severe parasitic infections 9 . In this context, certain parasitic infections can occur more frequently in patients with diabetes mellitus than in non-diabetics 1 , 5 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Blastocystis subtypes in patients with diabetes mellitus from the Midwest region of Brazil

Melo

Mazzaro

Gomes‐Gouvêa

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Intestinal parasitosis and associated factors among diabetic patients attending Arba Minch Hospital, Southern Ethiopia

Cited by 14 publications

References 10 publications

The Prevalence of Intestinal Parasites and Their Associated Factors among Diabetes Mellitus Patients at the University of Gondar Referral Hospital, Northwest Ethiopia

The Prevalence of Intestinal Parasites and Their Associated Factors among Diabetes Mellitus Patients at the University of Gondar Referral Hospital, Northwest Ethiopia

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Blastocystis subtypes in patients with diabetes mellitus from the Midwest region of Brazil

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