Intestinal Permeability and Absorption in Dogs with Traumatic Injury

Streeter, Elizabeth M.; Zsombor-Murray, Erika; Moore, Kari E.; Steiner, Jörg M.; Rozanski, Elizabeth A.; Michel, Kathryn E.; Williams, D. A.; Freeman, Lisa M.

doi:10.1892/0891-6640(2002)016<0669:ipaaid>2.3.co;2

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…The dogs in the previous study were different than humans in that by 72 hours after trauma, the L/R ratios were returning to normal, whereas humans continued to have abnormal L/ R ratios 96 hours after trauma. Poor intestinal blood flow could be responsible for the intestinal mucosal damage in both the study of Streeter et al 18 and our study. However, visceral ischemia is not supported by the study of Van Citters and Franklin, 19 who showed no reduction in splanchnic blood flow in exercising sled dogs.…”

Section: Discussionsupporting

confidence: 62%

“…A study on dogs with traumatic injury (eg, blunt trauma with fractures, hemothorax, or pneumothorax) found that their L/R ratio was significantly higher at 48 hours after trauma than that of controls. 18 Although mean values were not presented in that study, inspection of the figures shows that control dogs had a mean L/R of approximately 0.06, whereas dogs 48 hours after trauma had a mean L/R of approximately 0.10. The dogs in the previous study were different than humans in that by 72 hours after trauma, the L/R ratios were returning to normal, whereas humans continued to have abnormal L/ R ratios 96 hours after trauma.…”

Section: Discussionmentioning

confidence: 80%

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Sustained Strenuous Exercise Increases Intestinal Permeability in Racing Alaskan Sled Dogs

Davis

Willard

Williamson

et al. 2005

Veterinary Internal Medicne

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We assessed gastric and intestinal permeability and performed gastroscopy to evaluate the effects of sustained strenuous exercise on the gastrointestinal tract in racing sled dogs. Three teams of racing Alaskan sled dogs were examined approximately 1 week before and 24 hours after the 2003 Iditarod sled dog race (1,100 miles in 10 days). Each examination consisted of the administration of a solution of sucrose, lactulose, and rhamnose to evaluate gastric and intestinal permeability, as well as gastroscopy to visually inspect the gastric mucosa. Of the 54 dogs examined before the race, 16 completed the course and contributed data to the analysis. Sustained strenuous exercise was associated with an increased frequency of gastric erosions or ulcerations seen endoscopically (0% prerace versus 61% postrace). A significant postrace increase occurred in the median lactulose to rhamnose ratio in both serum and urine (0.11 versus 0.165, P = .0363; 0.11 versus 0.165, P = .0090, respectively). No significant differences were found in median serum or urinary sucrose concentrations when pre- and postrace values were compared. No correlation was found between visible gastric lesions and the concentration of sucrose in serum or urine samples obtained 4-5 hours after administration of the sugar solutions. We conclude that sustained strenuous exercise is associated with increased intestinal permeability, but the sucrose permeability test as we performed it did not correlate with visible gastric lesions.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 80%

Sustained Strenuous Exercise Increases Intestinal Permeability in Racing Alaskan Sled Dogs

Davis

Willard

Williamson

et al. 2005

Veterinary Internal Medicne

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“…51 GI disturbances in critically ill dogs have been poorly documented; however, a recent prospective study documented an increase in GI permeability in dogs with traumatic injury. 74 Additionally, research models have documented diminished canine intestinal motility following sublethal endotoxemia. 75 Clearly, further evaluation of GI function is warranted in critically ill dogs.…”

Section: Gi Dysfunctionmentioning

confidence: 99%

Multiple organ dysfunction syndrome in humans and dogs

Johnson

Gaynor

Chan

et al. 2004

J Vet Emergen Crit Care

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Objective: To describe the clinical appearance and theories on the pathogenesis of multiple organ dysfunction syndrome (MODS) in humans, and to review the evidence suggesting that a similar syndrome occurs in critically ill dogs. Human-based studies: Currently, there are a multitude of publications describing the pathogenesis and clinical course of MODS in humans. Providing much of the basis for on-going research and the development of clinical applications, a consensus statement made by the American College of Chest Physicians and Society of Critical Care Medicine defined parameters that had guided and shaped much of what is known about MODS. Veterinary-based studies: To date, there are few publications describing MODS in dogs and much of what is known has been derived from case reports and reviews of various critical illnesses in dogs. While a similar syndrome of multiple organ dysfunction likely exists in dogs, a consensus statement defining clinical parameters has not been made. Data sources: Veterinary and human literature review. Conclusions: The development of MODS in human critical illness is widely recognized and major strides have been made in the understanding of this complex syndrome. Scoring schemes applied to human MODS patients have established that with increasing numbers of failing organs, there is a worse prognosis. As a similar finding likely exists in dogs, an awareness of MODS is vital to veterinary critical care clinicians and a consensus definition of MODS in dogs is warranted. (J Vet Emerg Crit Care 2004; 14(3): 158-166)

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