Intestinal permeability and morphometric recovery in coeliac disease

Johnston, S D; Smye, Mike; Watson, R. G. P.

doi:10.1016/s0140-6736(01)05495-2

Cited by 14 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This continuing inflammation might be related to an eventual involuntary exposure of the intestinal mucosa to gliadin, with induction of an immunologic response that occurs both in the lamina propria and in the epithelium with a consequent reduction of resistance of tight junctions (19)(20)(21)(22)(23). The maintenance of intestinal permeability alterations in celiac disease patients is in agreement with the literature (24,25).…”

Section: Discussionsupporting

confidence: 86%

Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects

Vilela¹,

Torres²,

Ferrari³

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects

Vilela¹,

Torres²,

Ferrari³

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

“…Previous studies have shown alterations in intestinal permeability as an indicator of intestinal function, but histologic improvement is limited to a small number of patients [37,38].…”

Section: Discussionmentioning

confidence: 98%

Intestinal Permeability and Antigliadin Antibody Test for Monitoring Adult Patients with Celiac Disease

et al. 2007

View full text Add to dashboard Cite

Celiac disease causes chronic inflammation of the intestinal mucosa and reduces surface absorption; after the withdrawal of gluten from the diet, there are clinical and histologic improvements. The intestinal permeability test and serologic tests are useful for confirming the diagnosis and monitoring patients. The goal of this study is to compare the antigliadin antibody (AGA) test with the intestinal permeability test for celiac patients on a gluten-free diet. The sample consisted of 22 celiac patients who were antigliadin immunoglobulin A-positive before treatment. After 12 months on a gluten-free diet, AGA testing was repeated and the intestinal permeability test was performed. A control group was composed of 11 healthy individuals. AGA remained positive in 40.9% of celiac patients, and the mean urinary lactulose excretion was 10.27%, that of mannitol was 10.18%, and the lactulose/mannitol ratio was 1.02. In the subgroup in which antigliadin became negative (59.1%), the value for lactulose was 3.79%, that for mannitol was 11.12%, the lactulose/mannitol ratio was 0.38, and the p value was less than 0.0001, 0.66, and less than 0.0001, respectively. When the two celiac subgroups were compared with the control group, the urinary lactulose excretion and the lactulose/mannitol ratio was less in the control group, whereas urinary mannitol excretion was greater. The p values were less than 0.0001 for the three variables, suggesting persistent lesions in mucosa of both subgroups, although to a lesser degree for those that became AGA negative. It is concluded that intestinal permeability allows a more precise clinical physiopathologic correlation than antigliadin and offers more information for the monitoring of these patients.

show abstract

“…across the brush-border membrane by a carrier-mediated process or by paracellular diffusion (30)(31)(32)(33) . These sugars have been used extensively as indicators of malabsorption in birds (23,34) and to test intestinal barrier function in multiple species (35)(36)(37) .…”

Section: Discussionmentioning

confidence: 99%

Peroxidised dietary lipids impair intestinal function and morphology of the small intestine villi of nursery pigs in a dose-dependent manner

et al. 2015

View full text Add to dashboard Cite

The objective of this study was to investigate the effect of increasing degrees of lipid peroxidation on structure and function of the small intestine of nursery pigs. A total of 216 pigs (mean body weight was 6·5 kg) were randomly allotted within weight blocks and sex and fed one of five experimental diets for 35 d (eleven pens per treatment with three to four pigs per pen). Treatments included a control diet without added lipid, and diets supplemented with 6 % soyabean oil that was exposed to heat (80°C) and constant oxygen flow (1 litre/min) for 0, 6, 9 and 12 d. Increasing lipid peroxidation linearly reduced feed intake (P < 0·001) and weight gain (P = 0·024). Apparent faecal digestibility of gross energy (P = 0·001) and fat (P < 0·001) decreased linearly as the degree of peroxidation increased. Absorption of mannitol (linear, P = 0·097) and D-xylose (linear, P = 0·089), measured in serum 2 h post gavage with a solution containing 0·2 g/ml of D-xylose and 0·3 g/ml of mannitol, tended to decrease progressively as the peroxidation level increased. Increasing peroxidation also resulted in increased villi height (linear, P < 0·001) and crypt depth (quadratic, P = 0·005) in the jejunum. Increasing peroxidation increased malondialdehyde concentrations (quadratic, P = 0·035) and reduced the total antioxidant capacity (linear, P = 0·044) in the jejunal mucosa. In conclusion, lipid peroxidation progressively diminished animal performance and modified the function and morphology of the small intestine of nursery pigs. Detrimental effects were related with the disruption of redox environment of the intestinal mucosa.

show abstract

Intestinal permeability and morphometric recovery in coeliac disease

Cited by 14 publications

References 11 publications

Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects

Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects

Intestinal Permeability and Antigliadin Antibody Test for Monitoring Adult Patients with Celiac Disease

Peroxidised dietary lipids impair intestinal function and morphology of the small intestine villi of nursery pigs in a dose-dependent manner

Contact Info

Product

Resources

About