Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives.

Munkholm, Pia; Langholz, Ebbe; Hollander, Daniel; Thornberg, Klaus J.; Orholm, Marianne; Katz, Kent D.; Binder, Vibeke

doi:10.1136/gut.35.1.68

Cited by 177 publications

(110 citation statements)

References 22 publications

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“…Similar findings have been shown by Soderholm et al [23] . While Munkholm [32] and Jogerson et al [21] found a negative correlation of age with the absorption of mannitol and excretion of 51 CrEDTA, respectively.…”

Section: Discussionmentioning

confidence: 99%

Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease

Benjamin¹,

Makharia²,

Ahuja³

et al. 2008

WJG

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INTRODUCTIONIntestinal permeability (IP) is the property of the intestinal epithelium which refers to the facility with which it allows molecules to pass through by non-mediated diffusion [1] . IP has been implicated in the pathogenesis and frequent relapses of Crohn's disease (CD) [2][3][4][5][6] . Seven to 18% higher relapse rate has been reported in patients with increased IP compared to those with normal IP [7][8][9][10][11] . Moreover, RAPID COMMUNICATIONIntestinal permeability and its association with the patient and disease characteristics in Crohn's disease Abstract AIM: To assess the intestinal permeability (IP) in patients with Crohn's disease (CD) and study the association of IP with the patient and disease characteristics.

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Section: Discussionmentioning

confidence: 99%

Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease

Benjamin¹,

Makharia²,

Ahuja³

et al. 2008

WJG

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show abstract

“…DCA, the other secretory bile acid, also has an extremely low aqueous concentration in the cecum because of its insolubility (2). Thus (37)(38)(39)(40)42).…”

Section: Discussionmentioning

confidence: 99%

“…If this occurs, CDCA would also enter the mucosa via the paracellular pathway and interact directly with the basolateral membrane of the enterocytes, as well as with mast cells. In conditions of intestinal inflammation, in which both intestinal permeability and the number of mucosal mast cells might be expected to be elevated (37)(38)(39)(40), the tissue might be expected to respond to much lower concentrations of CDCA present in the colonic contents.…”

Section: Discussionmentioning

confidence: 99%

Mast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon.

Gelbmann¹,

Schteingart²,

Thompson³

et al. 1995

J. Clin. Invest.

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Certain dihydroxy bile acids cause secretory diarrhea when present in the colonic lumen at inappropriately high concentrations. However, the mechanism underlying the secretagogue activity has not been fully elucidated. Experiments were performed to test whether mast cells and one of their major mediators, histamine, might contribute to the secretory effect. Chenodeoxycholic acid, a secretory bile acid, and ursodeoxycholic acid, a nonsecretory, hydrophilic bile acid, were compared for their ability to induce chloride secretion across segments of mouse colon mounted in Ussing chambers. Chenodeoxycholic acid, but not ursodeoxycholic acid, induced dose-dependent, biphasic chloride secretion that was greater after serosal than mucosal addition and was greater in distal versus proximal colonic segments. The secretory effect of chenodeoxycholic acid was inhibited by H1 histamine receptor antagonists and modified by the cyclooxygenase inhibitor indomethacin. However, it was unaffected by an H2 histamine receptor antagonist or by atropine. Secretory effects of chenodeoxycholic acid were diminished in magnitude and delayed in colonic tissues from mice with a genetic deficiency of tissue mast cells. Concentrations of chenodeoxycholic acid inducing secretion also released histamine from tissue segments. These data indicate that mast cells and histamine-mediated processes contribute significantly to the secretory effects of dihydroxy bile acids in the murine colon. (J. Clin. Invest. 1995. 95:2831-2839

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“…Ulcerative colitis and Crohn's disease alter intestinal permeability [25], allowing systemic exposure to antigens that would otherwise be excluded. Gastrointestinal alteration has similarly been noted in undifferentiated spondyloarthropathy [26].…”

Section: Journal Of Infectious Diseases and Preventive Medicinementioning

confidence: 99%

Arthritis through Geologic Time and its Environmental Implications

Rothschild¹,

Wen²,

Deng³

et al. 2013

J Anc Dis Prev Rem

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The evolutionary significance of the geometric increased in prevalence of a specific disease, a form of inflammatory arthritis referred to as spondyloarthropathy, suggests either an as yet undetermined organismal benefit or an increase in environmental contamination. Recognized on the basis of sacroiliac joint pathology, the character and prevalence were assessed in Rhinoceridae in North American, European and Asian paleontological collections. Bemalambda had identical pathology to that found in Corythodon. Sacroiliac fusion was noted in seven Plesiaceratherium gracile and in two Coelodonta antiquitatis. Miocene and Pleistocene occurrence in Europe and Asia revealed the identical trend to that noted in North America. Given the independent occurrence (Europe/Asia and North America) and parallel increase in population penetrance of spondyloarthropathy through geologic time and evidence from contaminated human sites, the results provides a window to an environmental exposure problem that has exacerbated over geologic time.

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Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives.

Cited by 177 publications

References 22 publications

Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease

Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease

Mast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon.

Arthritis through Geologic Time and its Environmental Implications

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