Intestinal phages interact with bacteria and are involved in human diseases

Han, Shuwen; Ding, Kefeng

doi:10.1080/19490976.2022.2113717

Cited by 52 publications

(40 citation statements)

References 155 publications

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“…There has recently been a renewed interest in the use of bacteriophages (phages) for clinical and environmental applications. In contrast to antibiotics, phages are specific in their targets without directly affecting the normal microbiota of the host, and they are capable of auto-dosing for phage replication [ 15 ]. However, a major concern regarding the use of phages in the treatment of infectious diseases was the emergence of phage-resistant mutants [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

Liang

Huang

Cui

et al. 2022

IJMS

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Effective phage cocktails consisting of multiple virus types are essential for successful phage therapy against pandrug-resistant pathogens, including Salmonella enterica serovar (S.) Typhimurium. Here we show that a Salmonella phage, F118P13, with non-productive infection and a lytic phage, PLL1, combined to inhibit pandrug-resistant S. Typhimurium growth and significantly limited resistance to phages in vitro. Further, intraperitoneal injection with this unique phage combination completely protected mice from Salmonella-induced death and inhibited bacterial proliferation rapidly in various organs. Furthermore, the phage combination treatment significantly attenuated the inflammatory response, restored the generation of CD4+ T cells repressed by Salmonella, and allowed macrophages and granulocytes to participate in immunophage synergy to promote bacterial clearance. Crucially, the non-productive phage F118P13 is less likely to be cleared by the immune system in vivo, thus providing an alternative to phage cocktail against bacterial infections.

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Section: Introductionmentioning

confidence: 99%

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

Liang

Huang

Cui

et al. 2022

IJMS

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“…Recent studies have demonstrated a correlation between gut phage composition and host health, phage therapy as an antibacterial agent, and the application of genetically engineered phages in gut microbiome remodeling (154, 155). Directed chemical manipulation provides additional tools for deciphering the chemical biology of the gut microbiome and designing phagecontaining supplements to target remodeling of the gut microbiota (156). The elimination of specific pathogens can correct gut dysbiosis and improve gut barrier function (157).…”

Section: Small Molecule Compounds Engineer the Gut Microbiomementioning

confidence: 99%

Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy

Zhang

Zhu²,

Yu³

et al. 2023

Front. Nutr.

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Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient absorption and prevents pathogenic entry, harmful metabolites, and endotoxin absorption. Recent advances have highlighted the association between severely damaged intestinal barriers and diabetes, obesity, fatty liver, and cardiovascular diseases. Evidence indicates that an abated intestinal barrier leads to endotoxemia associated with systemic inflammation, insulin resistance, diabetes, and lipid accumulation, accelerating obesity and fatty liver diseases. Nonetheless, the specific mechanism of intestinal barrier damage and the effective improvement of the intestinal barrier remain to be explored. Here, we discuss the crosstalk between changes in the intestinal barrier and metabolic disease. This paper also highlights how to improve the gut barrier from the perspective of natural medicine, gut microbiota remodeling, lifestyle interventions, and bariatric surgery. Finally, potential challenges and prospects for the regulation of the gut barrier-metabolic disease axis are discussed, which may provide theoretical guidance for the treatment of metabolic diseases.

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“…In rabbits with IL-1 beta-mediated fever, Lj exerts antipyretic activity, inhibiting the expression of the receptor EP3 in pre-optic anterior hypothalamus [ 148 ]. Finally, for its content in bifido-flavonoids, LJ inhibits the NF-kB pathway with abrogation of COX2 and PGE2 synthesis [ 149 ]. The main antipyretic compounds are indicated in Figure 3 .…”

Section: Antipyretic Moleculesmentioning

confidence: 99%

Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications

et al. 2023

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Fever represents an elevation of body temperature, that exerts a protective effect against pathogens. Innate immune cells and neurons are implicated in the regulation of body temperature. Pathogen-associated molecular patterns, i.e., lipopolysaccharides from Gram-negative bacteria and peptidoglycan and lipoteichoic acid from Gram-positive bacteria are exogenous pyrogens, that bind to Toll-like receptors on immune and non-immune cells. The subsequent release of pro-inflammatory cytokines [interleukin-1 (IL-1), IL-6 and Tumor necrosis factor-alpha] and their passage through the brain trigger the febrile response. In fact, neurons of the pre-optic area produce prostaglandin E2 (PGE2), that, in turn, bind to the PGE2 receptors; thus, generating fever. Apart from classical non-steroidal anti-inflammatory drugs, i.e., aspirin and acetaminophen, various botanicals are currently used as antipyretic agents and, therefore, their mechanisms of action will be elucidated.

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Intestinal phages interact with bacteria and are involved in human diseases

Cited by 52 publications

References 155 publications

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy

Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications

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