Intestinal Protein Loss in Crohn's Disease

Alpha 1-antitrypsin, a reliable endogenous marker for intestinal protein loss and its application in patients with Crohn's disease.

“…If all patients with Crohn's disease lost serum proteins into the intestinal lumen one should expect a quantitative correlation of intestinal protein loss or serum albumin concentrations and extent and/or severity of disease. 13 17 This was not so in our cases. Even patients with apparent curative resection had raised values while others with a high activity index or those with extensive involvement had relatively minor protein losses (Figs.…”

Risk factors for vitamin D deficiency in patients with Crohn’s disease

“…Protein-losing enteropathy occurs commonly, and protein-bound 25-OHD also might be lost in the diseased intestine. 17 The active phase of Crohn's disease may be associated with a protein-losing enteropathy that may account for the low levels of 25-OHD. An analogous situation is the nephritic syndrome; in these patients, protein-bound 25-OHD is lost in the urine and vitamin D deficiency commonly occurs.…”

Protein-Losing Enteropathies

“…This is evident in the fact that serum albumin values are not infrequently reduced in active IBD and sometimes are severely reduced (Steinfeld et al, 1960;Beeker et al, 1972). In addition, as mentioned before, metabolic studies of IBD patients with radiolabeled albumin disclosed that many patients have increased fractional catabolic rates of albumin, as well as abnormal findings in tests for loss of protein into the GI tract (Steinfeld et al, 1960).…”