Intestinal pseudo-obstruction with bacterial overgrowth in the small intestine

Pearson, A J; Brzechwa-Ajdukiewicz, A; McCarthy, C. F.

doi:10.1007/bf02235883

Cited by 56 publications

(9 citation statements)

References 10 publications

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“…In both studies, an association among some symptoms analyzed in these patients and SIBO was established. Similar findings were observed in adults: in some gastrointestinal disorders, SIBO is frequently seen, for example, with anatomic changes of the small intestine, such as jejuno-ileal ''by-pass'', that used to be performed in the 1980s to treat obesity [13,14], other forms of blind loop [15], duodenal diverticula [16], and in severe motility alterations (intestinal pseudo-obstruction) [17]. In these cases, bacterial colonization of the small intestine is associated with clinical manifestations of diarrhea, bloating, and sometimes malabsorption; all of which positively respond to antibiotic treatment [18].…”

Section: Introductionsupporting

confidence: 52%

Lactulose Hydrogen Breath Test and Functional Symptoms in Pediatric Patients

et al. 2012

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Section: Introductionsupporting

confidence: 52%

Lactulose Hydrogen Breath Test and Functional Symptoms in Pediatric Patients

et al. 2012

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“…The MMC has been called the ‘intestinal housekeeper’, because its absence or disturbance is associated with small-bowel bacterial overgrowth in patients with scleroderma or other diseases in which the MMC functions improperly [10, 11, 15, 16, 17, 18, 19]. …”

Section: Discussionmentioning

confidence: 99%

Obstructive Jaundice, Bacterial Translocation and Interdigestive Small-Bowel Motility in Rats

Nieuwenhuijs

Dijk²,

Gooszen³

et al. 2000

Digestion

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Background/Aims: Translocation of gut bacteria occurs in obstructive jaundice, the underlying mechanisms are unclear. We designed this experimental study to investigate the association between interdigestive motility and the pathogenesis of bacterial translocation during biliary obstruction. Methods: Rats were fitted with jejunal myoelectrodes for the measurement of the interdigestive migrating motor complex (MMC) and with two cannulas in the proximal common bile duct (CBD) for exteriorization of biliary flow. This allowed measurement of MMCs under control conditions with an intact enterohepatic circulation and during 3 days of CBD obstruction without surgical intervention. Mesenteric lymph nodes, liver, spleen and segments of the duodenum, the jejunum and the caecum were removed for microbial culturing. Results: The MMC cycle length increased from 17.3 min before CBD obstruction to 31.9, 34.1, and 25.3 min on days 1, 2 and 3, respectively, after CBD obstruction (p < 0.05 for all days). Bacterial levels in the jejunum were significantly higher in CBD-obstructed rats than in control rats. The translocation incidence was significantly higher in rats with CBD obstruction (6/8) than in control rats (1/8). The bacterial levels in the jejunum correlated significantly with the MMC cycle length (r = 0.60, p <0.05). Conclusion: Experimental biliary obstruction is associated with disturbance of MMCs, small-bowel bacterial overgrowth and increased bacterial translocation.

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“…Vagotomy and hemigastrectomy (7,8), scleroderma (9), diabetic autonomic neuropathy (10), and idiopathic intestinal pseudo-obstruction (11) are diseases characterized by impaired motor function of the intestine and are associated with abnormal proliferation of bacteria within the lumen of the small intestine. A specific mechanism…”

Section: Introductionmentioning

confidence: 99%

Altered myoelectric activity in the experimental blind loop syndrome.

Justus¹,

Fernández²,

Martin³

et al. 1983

J. Clin. Invest.

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A B S T R A C T Nutrient malabsorption and diarrhea are characteristic of the blind loop syndrome. Alterations in motility have been implicated as a cause of bacterial overgrowth, but the possibility that altered motility may result from alterations in the flora has not been explored. The purpose of this study was to characterize the myoelectric activity of the small intestine in the blind loop rat model. Eight groups of rats were studied: rats with self-filling blind loops, which develop bacterial overgrowth; rats with selfemptying blind loops, which are surgical controls that do not develop overgrowth; unoperated litter mates; rats with self-filling blind loops and unoperated controls treated with chloramphenicol, 200 mg/d i.p.; rats with surgically removed self-filling blind loops; operated control rats; and gnotobiotic rats with self-filling blind loops. In the untreated rats with self-filling blind loops, there was altered myoelectric activity characterized by an increased percentage of slow waves occupied by action potentials and by organized activity similar to the migrating action potential complex. Migrating action potential complex activity and percentage of slow waves occupied by action potentials were significantly decreased with chloramphenicol therapy; that decrease correlated with a decrease in aerobes and anaerobes. Migrating action potential complex activity was abolished in rats with surgically removed self-filling blind loops; they also showed a significant decrease in percentage of slow waves occupied by action potentials. Gnotobiotic rats with self-

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Intestinal pseudo-obstruction with bacterial overgrowth in the small intestine

Cited by 56 publications

References 10 publications

Lactulose Hydrogen Breath Test and Functional Symptoms in Pediatric Patients

Lactulose Hydrogen Breath Test and Functional Symptoms in Pediatric Patients

Obstructive Jaundice, Bacterial Translocation and Interdigestive Small-Bowel Motility in Rats

Altered myoelectric activity in the experimental blind loop syndrome.

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