Intestinal resection affects whole-body arginine synthesis in neonatal piglets

Lansing, Marihan; Slim, George; Wizzard, Pamela; Rafii, Mahroukh; Pencharz, Paul B.; Nation, Patrick N.; Beggs, Megan R; Alexander, R. Todd; Wales, Paul W.; Turner, Justine; Ball, Ron O

doi:10.1038/s41390-020-01139-1

Cited by 1 publication

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“…Furthermore, oral ARG supplementation may result in dose-dependent GI distress, causing increased activity and bioavailability of CIT compared to ARG. Lancing et al recently demonstrated that intestinal resection in neonatal piglets affected whole-body ARG synthesis but that the resected animals exhibited increased ARG synthesis after adjusting for absolute small intestinal length [ 37 ]. In another experiment, Jiang et al showed that continuous oral supplementation of L-ARG can stimulate IA after gut resection in rats [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Dietary Protein on the Management of Pediatric Short Bowel Syndrome

2023

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Essential amino acids (AAs) play a key role in stimulating intestinal adaptation after massive small gut resection. The nutritional effect of dietary amino acids during intestinal regrowth has received considerable attention in recent years. This review explores the significance of dietary amino acids in the nutritional management of infants and children with intestinal failure and short bowel syndrome (SBS) as reported in the medical literature over the last three decades. A literature search was conducted using electronic databases. Breast milk emerged as the first-line enteral regimen recommended for infants with SBS. Hydrolyzed formulas (HFs) or amino acid formulas (AAFs) are recommended when breast milk is not available or if the infant cannot tolerate whole protein milk. The superiority of AAFs over HFs has never been demonstrated. Although glutamine (GLN) is the main fuel for enterocytes, GLN supplementation in infants with SBS showed no difference in the child’s dependence upon parenteral nutrition (PN). Circulating citrulline is considered a major determinant of survival and nutritional prognosis of SBS patients. Early enteral nutrition and dietary supplementation of AAs following bowel resection in children are essential for the development of intestinal adaptation, thereby eliminating the need for PN.

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Section: Introductionmentioning

confidence: 99%