Intestinal spirochetosis and colon diverticulosis

Lima, Marcus Aurelho de; Barbosa, André Luís; Santos, Vitorino Modesto dos; Misiara, Felipe Prata

doi:10.1590/s0037-86822005000100011

Cited by 6 publications

(7 citation statements)

References 9 publications

(4 reference statements)

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“…At the time of sampling she was reported to have influenza-like symptoms and she had suffered from diverticulitis. It was unclear whether these complaints were linked to the colonization, although an association between diverticulitis and intestinal spirochaetosis has been reported previously (Lima et al, 2005). The woman had a pet dog in her house but a faecal sample taken from the animal was negative for B. pilosicoli.…”

Section: B Pilosicoli Amongst Long-term Residents Of Perthmentioning

confidence: 94%

Isolation of the anaerobic intestinal spirochaete Brachyspira pilosicoli from long-term residents and Indonesian visitors to Perth, Western Australia

Margawani

Robertson

Hampson

2009

Journal of Medical Microbiology

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Brachyspira pilosicoli is an anaerobic spirochaete that colonizes the large intestine of humans and various species of animals and birds. The spirochaete is an important enteric pathogen of pigs and poultry, but its pathogenic potential in humans is less clear. In the current study, the occurrence of B. pilosicoli in faecal samples from 766 individuals in two different population groups in Perth, Western Australia, was investigated by selective anaerobic culture. Of 586 individuals who were long-term residents of Perth, including children, elderly patients in care and in hospital and individuals with gastrointestinal disease, only one was culture positive. This person had a history of diverticulitis. In comparison, faeces from 17 of 180 (9.4 %) Indonesians who were short-or medium-term visitors to Perth were positive for B. pilosicoli. The culture-positive individuals had been in the city for between 10 days and 4.5 years (median 5 months). Resampling of subsets of the Indonesians indicated that all negative people remained negative and that some positive individuals remained positive after 5 months. Two individuals had pairs of isolates recovered after 4 and 5 months that had the same PFGE types, whilst another individual had isolates with two different PFGE types that were identified 2 months apart. Individuals who were culture-positive were likely to have been either colonized in Indonesia before arriving in Perth or infected in Perth following contact with other culture-positive Indonesians with whom they socialized. Colonization with B. pilosicoli was not significantly associated with clinical signs at the time the individuals were tested, although faeces with wet-clay consistency were 1.5 times more likely (confidence interval 0.55-4.6) than normal faeces to contain B. pilosicoli.

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Section: B Pilosicoli Amongst Long-term Residents Of Perthmentioning

confidence: 94%

Isolation of the anaerobic intestinal spirochaete Brachyspira pilosicoli from long-term residents and Indonesian visitors to Perth, Western Australia

Margawani

Robertson

Hampson

2009

Journal of Medical Microbiology

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“…Human intestinal spirochetosis (HIS) is an uncommon entity often evolving unsuspected and may be incidentally detected in male patients who underwent colonoscopy with biopsy evaluations. [1][2][3][4][5][6] The major predisposing factors are male homosexuality and immunocompromised health conditions; the patients may be asymptomatic or have abdominal pain and chronic watery or bloody diarrhea. [1][2][3][4][5][6] The agents are from the Brachyspiraceae family (Brachyspira aalborgi and Brachyspira pilosicoli), and intestinal changes as polyps, diverticula, tubular adenoma, and aphthous ulcers are described.…”

Section: Human Intestinal Spirochetosis: a Challenging Conditionmentioning

confidence: 99%

“…[1][2][3][4][5][6] The major predisposing factors are male homosexuality and immunocompromised health conditions; the patients may be asymptomatic or have abdominal pain and chronic watery or bloody diarrhea. [1][2][3][4][5][6] The agents are from the Brachyspiraceae family (Brachyspira aalborgi and Brachyspira pilosicoli), and intestinal changes as polyps, diverticula, tubular adenoma, and aphthous ulcers are described. [1][2][3][4][5][6] Diagnosis confirmation depends on histopathology features including the classical presence of the agents in epithelial surface appearing as thread-like structures mimicking a palisade ("blue fringe").…”

Section: Human Intestinal Spirochetosis: a Challenging Conditionmentioning

confidence: 99%

“…[1][2][3][4][5][6] Metronidazole, clindamycin, macrolides, and penicillin G are utilized to treat symptomatic patients. [1][2][3][4][5][6] We read the recent retrospective study of Garcia-Hernandez et al performed in Spain between 2009 and 2018, which detected six men who had sex with men and acquired the sexually transmitted HIS. The median age of these patients was 31.5 years, 50% were HIV-positive, 30% had rectal gonorrhea, one had rectal Chlamydia trachomatis, and in all of them, the serological tests for syphilis were negative.…”

Section: Human Intestinal Spirochetosis: a Challenging Conditionmentioning

confidence: 99%

“…[1][2][3][4][5][6] The agents are from the Brachyspiraceae family (Brachyspira aalborgi and Brachyspira pilosicoli), and intestinal changes as polyps, diverticula, tubular adenoma, and aphthous ulcers are described. [1][2][3][4][5][6] Diagnosis confirmation depends on histopathology features including the classical presence of the agents in epithelial surface appearing as thread-like structures mimicking a palisade ("blue fringe"). [1][2][3][4][5][6] Metronidazole, clindamycin, macrolides, and penicillin G are utilized to treat symptomatic patients.…”

Section: Human Intestinal Spirochetosis: a Challenging Conditionmentioning

confidence: 99%

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Human intestinal spirochetosis: A challenging condition

Santos

Modesto²,

Modesto

2022

Int J STD AIDS

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Penicillin resistance in the intestinal spirochaete Brachyspira pilosicoli associated with OXA-136 and OXA-137, two new variants of the class D β-lactamase OXA-63

Mortimer-Jones

Phillips

et al. 2008

Journal of Medical Microbiology

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Penicillin resistance mediated by b-lactamase activity has been reported previously in the anaerobic intestinal spirochaete Brachyspira pilosicoli, and a novel class D b-lactamase (OXA-63) hydrolysing oxacillin was described recently in a resistant human strain from France. In the current study, 18 B. pilosicoli strains from Australia and Papua New Guinea were tested for ampicillin and oxacillin susceptibility, and investigated for the presence of the class D b-lactamase gene bla OXA-63 using PCR. PCR products were amplified from seven human and four porcine strains that were penicillin resistant, but not from seven penicillin-sensitive strains. Sequence analysis of the whole gene amplified from seven of the resistant strains from humans and pigs revealed only minor nucleotide differences among them, but there were significant differences compared with bla OXA-63 . The predicted amino acid sequence of the enzyme from all seven strains had the same key structural motifs as the previously reported OXA-63, but two variants with 94-95 % identity with OXA-63 were identified. OXA-136 had an additional amino acid and 12 other consistent amino acid substitutions compared with OXA-63. OXA-137 had the same differences compared with OXA-63 as OXA-136, but had an additional amino acid substitution at position 16. No structures consistent with integrons or transposons were found in the nucleotide sequences in the vicinity of bla OXA-136 in partially sequenced B. pilosicoli strain 95/1000, and the GC content (25.2 mol%) of the gene was similar to that of the whole genome. The gene encoding OXA-136 from B. pilosicoli strain Cof-10 conferred penicillin resistance on Escherichia coli. This study shows that penicillin resistance in human and porcine B. pilosicoli strains from Australia is associated with the production of two variants of OXA-63, and that susceptible strains lack the genes encoding OXA-63 or the variants.

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Intestinal spirochetosis and colon diverticulosis

Abstract: ABSTRACT

Cited by 6 publications

References 9 publications

Isolation of the anaerobic intestinal spirochaete Brachyspira pilosicoli from long-term residents and Indonesian visitors to Perth, Western Australia

Isolation of the anaerobic intestinal spirochaete Brachyspira pilosicoli from long-term residents and Indonesian visitors to Perth, Western Australia

Human intestinal spirochetosis: A challenging condition

Penicillin resistance in the intestinal spirochaete Brachyspira pilosicoli associated with OXA-136 and OXA-137, two new variants of the class D β-lactamase OXA-63

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