Intestinal T-cell and NK/T-cell lymphomas: A clinicopathological study of 27 Chinese patients

Tang, Xuefeng; Yang, Li; Duan, Song; Guo, Hong; Guo, Qiao‐Nan

doi:10.1016/j.anndiagpath.2018.10.004

Cited by 24 publications

(26 citation statements)

References 11 publications

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“…The most common site of involvement of PIENKTL is the colon, followed by the jejunoileum and ileocecum. The prevalence is higher in the third decade of life (5)(6)(7)(8). A small number of patients with intestinal NK/T cell lymphoma will have a complication of perforation, including the case we present.…”

Section: Discussionmentioning

confidence: 70%

“…The tumor cells of PIENKTL are usually small to medium in size. The neoplastic cells of EATL are medium to large in size with prominent nucleoli, and they can have an immunoblastic or anaplastic appearance (6,(25)(26)(27). Most T cell and NK/T cell lymphomas have a common histological feature: irregular tumor cells of different shape or size mixed with inflammatory component.…”

Section: Discussionmentioning

confidence: 99%

“…However, MEITL is an exception, for it shows with monotonous small tumor cells and few reactive cells. In addition, angiocentrity can usually be observed in PIENKTL and EATL, while it is absent in MEITL (6). Most MEITLs are positive for megakaryocyteassociated tyrosine kinase, which is diagnostically useful when expressed by >80% of cells (25).…”

Section: Discussionmentioning

confidence: 99%

“…Most MEITLs are positive for megakaryocyteassociated tyrosine kinase, which is diagnostically useful when expressed by >80% of cells (25). In situ hybridization for EBER plays a key role in differential diagnosis, which is negative in EATL, MEITL, and PTCL, NOS cases while positive in PIENKTL cases (6). The diagnosis of PTCL, NOS is based on the exclusion of all the other T cell lymphomas.…”

Section: Discussionmentioning

confidence: 99%

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Case Report: Primary NK/T Cell Lymphoma Nasal Type of the Colon With Multiple Intestinal Perforations

et al. 2021

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Background: Extranodal NK/T cell lymphoma is a rare non-Hodgkin lymphoma mainly involving the upper aerodigestive tract, even rarer is primary extranasal disease involving the intestine. We present a case of primary intestinal NK/T cell lymphoma with diagnostic challenge, which eventually developed into multiple intestinal perforations.Case Presentation: A 35-year-old man presented with diarrhea and recurrent fever. Abdominal CT revealed multi-segmental intestinal wall thickening. Colonoscopy showed multiple irregular ulcers in colon. During the hospitalization, the patient developed intestinal perforation and an emergency surgery was performed. The resected specimen showed multiple perforations of the colon. The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. After recovering from surgery, the patient started receiving chemotherapy and PD-1 monoclonal antibody. Fortunately, he was discharged after significant improvement in his general condition. Eleven months follow-up was uneventful.Conclusion: Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. Most patients were definitely diagnosed only after surgical resection following complications, resulting in a poor prognosis. Therefore, doctors should maintain high suspicion of this malignancy for early diagnosis at an early stage clinically.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Case Report: Primary NK/T Cell Lymphoma Nasal Type of the Colon With Multiple Intestinal Perforations

et al. 2021

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“…CD56 and nuclear expression of MATK are positive in both MEITL and NK/T-cell lymphoma. In situ hybridization for Epstein-Barr virus-encoded small RNA (EBER) is required for confirmation of NK/T-cell lymphoma [13]. In our case, EBER was not performed as histomorphology was not consistent with NK/T-cell lymphoma.…”

Section: Discussionmentioning

confidence: 97%

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma Presenting With Jejunal Perforation: A Challanging Diagnosis

Shukla¹,

Dabadghao²,

Singh³

2020

IJCR

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Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an extremely rare and highly aggressive form of primary intestinal T-cell lymphoma previously classified as type II enteropathy-associated T-cell lymphoma (EATL). It has no clear association with coeliac disease and has varied non-specific clinical presentations and radiological findings. Herein, we discuss a case of MEITL presenting as jejunal perforation that was initially considered to be tuberculosis. Even in the presence of wellestablished epidemiological, histopathological, and immunophenotypic features, the diagnosis was delayed.

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Enteropathy‐Associated and Monomorphic Epitheliotropic Intestinal T‐cell Lymphomas

Soderquist

Shingleton

Davé

et al. 2021

The Peripheral T‐Cell Lymphomas

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Intestinal T-cell and NK/T-cell lymphomas: A clinicopathological study of 27 Chinese patients

Cited by 24 publications

References 11 publications

Case Report: Primary NK/T Cell Lymphoma Nasal Type of the Colon With Multiple Intestinal Perforations

Case Report: Primary NK/T Cell Lymphoma Nasal Type of the Colon With Multiple Intestinal Perforations

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma Presenting With Jejunal Perforation: A Challanging Diagnosis

Enteropathy‐Associated and Monomorphic Epitheliotropic Intestinal T‐cell Lymphomas

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