Intestinal T-Cell Lymphoma with Severe Hypereosinophilic Syndrome in a Cat

Abstract

ABSTRACT. A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic with only prednisolone administration, the cat presented with hematemesis, weight loss, and severe anorexia 512 days after the initial presentation. Subsequently, gastrointestinal perforation developed, and the cat died on Day 536. Histopathological examination of autopsy specimens revealed mixed cellular infiltration including eosinophils and neoplastic lymphocytes in the intestinal lymph nodes, intestine, liver, spleen, and pancreas. Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome.

Eosinophilic meningomyelitis associated with T‐cell lymphoma in a cat

“…In the cat of the present report, eosinophils predominated in the CSF, and were found throughout the neoplasm. However, unlike previous reports of hypereosinophilic syndrome or paraneoplastic hypereosinophilia associated with gastrointestinal T‐cell lymphoma, no peripheral blood or bone marrow eosinophilia was present . Tissue and/or peripheral blood eosinophilia occurs in association with various human lymphoid malignancies, especially Hodgkin's lymphoma and T‐cell‐derived neoplasms .…”

Equine multi‐systemic eosinophilic epitheliotropic disease

“…; Takeuchi et al . ). Systemic hypereosinophilia has also been reported to precede the development of lymphoma in man (Gleich and Leiferman ).…”

“…; Takeuchi et al . , ). These cats tend to be middle aged or older and typically demonstrate marked peripheral eosinophilia and may have eosinophilic infiltration of the liver, lungs, spleen, lymph nodes, gastrointestinal tract, heart and adrenals (Wilson et al .…”

“…; Takeuchi et al . , ). Additionally, association with chronic valvular endocarditis has been observed in a cat (unpublished).…”

“…Affected dogs are frequently young, and Rottweilers may be predisposed (Sykes et al 2001;James and Mansfield 2009). Cats may also demonstrate a multi-systemic hypereosinophilic syndrome (Wilson et al 1996;Barrs et al 2002;Marchetti et al 2005;Takeuchi et al 2008Takeuchi et al , 2012. These cats tend to be middle aged or older and typically demonstrate marked peripheral eosinophilia and may have eosinophilic infiltration of the liver, lungs, spleen, lymph nodes, gastrointestinal tract, heart and adrenals (Wilson et al 1996;Barrs et al 2002;Takeuchi et al 2008Takeuchi et al , 2012.…”