Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress

Lastra, Catalina Alarcón de la; Nieto, Ana; Motilva, Virginia; Martin, M. J.; Herrerias, Juan Manuel; Cabré, Francesc; Mauleón, David

doi:10.1007/s000110050640

Cited by 23 publications

(7 citation statements)

References 30 publications

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“…Photographs showing the morphology and injury of the incised gastric tissues were taken to score the pathological lesions on the internal surface, as reported by de la Lastra et al . : scored as 0, no lesions; 1, vasodilatation or erythema; 2, 1–10 scattered small ulcers (<5 mm); 3, >10 scattered small ulcers (<5 mm); 4, 1–10 scattered moderate ulcers (5–10 mm); 5, >10 scattered moderate ulcers (5–10 mm); 6, 1–5 longitudinal ulcers (>10 mm); 7, >5 longitudinal ulcers (>10 mm). ImageJ software analysis was performed to characterize the gastric injury and was calculated as follows: …”

Section: Methodsmentioning

confidence: 99%

Tricholoma matsutake-Derived Peptides Show Gastroprotective Effects against Ethanol-Induced Acute Gastric Injury

et al. 2021

J. Agric. Food Chem.

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Acute gastric injury caused by ethanol is a frequent disorder of the gastrointestinal tract. In this study, we investigated the potential gastroprotective effects of Tricholoma matsutake-derived peptides against ethanol-triggered acute gastric injury and the associated mechanisms. Peptides SDLKHFPF and SDIKHFPF significantly attenuated the ethanol-induced decrease in GES-1 cell survival (82.39 ± 1.93 and 80.10 ± 1.08% vs 56.58 ± 1.86%), inhibited GES-1 cell apoptosis, and alleviated the ethanol-induced gastric mucosal injury (64.76 ± 3.98 and 49.29 ± 3.25%), ulcer index (3.33 ± 0.47 and 4.67 ± 0.47 vs 6.67 ± 0.47), and histopathological changes in mice. Peptide treatment inhibited the phosphorylation and nuclear translocation of nuclear factor kappa B (NF-κB), the secretion of tumor necrosis factor-α, interleukin-6, and endothelin-1. In addition, T. matsutake peptide pretreatment increased growth factor secretion, upregulated B-cell lymphoma-2, downregulated Bcl-2-associated X (Bax), and cleaved cysteinyl aspartate specific proteinase 3, thereby promoting gastric cell survival. These findings strongly suggest that T. matsutake peptides attenuate ethanol-induced inflammatory responses and apoptosis by suppressing NF-κB signaling activation, thereby enhancing gastric epithelial barrier functions.

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Section: Methodsmentioning

confidence: 99%

Tricholoma matsutake-Derived Peptides Show Gastroprotective Effects against Ethanol-Induced Acute Gastric Injury

et al. 2021

J. Agric. Food Chem.

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“…Most data on experimental NSAID-induced enteropathy have been published for acute or chronic studies using rat models [12][13][14][15][16][17][18][19][20][21]. We decided to use experimental pigs in our project because of similarities with human gastrointestinal anatomy and physiology [22].…”

Section: Discussionmentioning

confidence: 99%

Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs

et al. 2009

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“…The gastrointestinal tissues were fixed in formaldehyde (10%) and processed for histopathological studies according to the standard method and stained by hematoxylin/eosin (H&E) solutions. The pathological features of the gastrointestinal inner surface were scored as described by de la Lastra et al as follows: score 0 = no lesions; score 1 = vasodilatation or erythema; score 2 = 1–10 scattered small ulcers (<5 mm); score 3 = more than 10 scattered small ulcers (<5 mm); score 4 = 1–10 scattered medium ulcers (5–10 mm); score 5 = more than 10 scattered medium ulcers (5–10 mm); score 6 = 1–5 longitudinal ulcers (>10 mm); score 7 = more than five longitudinal ulcers (>10 mm).…”

Section: Methodsmentioning

confidence: 99%

Beneficial Effects of Camellia Oil (Camellia oleifera Abel.) on Ketoprofen-Induced Gastrointestinal Mucosal Damage through Upregulation of HO-1 and VEGF

Cheng

et al. 2014

J. Agric. Food Chem.

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Nonsteroidal anti-inflammatory drugs, such as ketoprofen, are generally used to treat pain and inflammation and as pyretic agents in clinical medicine. However, the usage of these drugs may lead to oxidative injury to the gastrointestinal mucosa. Camellia oil ( Camellia oleifera Abel.) is commonly used in Taiwan and China as cooking oil. Traditional remedies containing this oil exert beneficial health effects on the bowel, stomach, liver, and lungs. However, the effects of camellia oil on ketoprofen-induced oxidative gastrointestinal mucosal lesions remain unknown. The objective of this study was to evaluate the effect of camellia oil on ketoprofen-induced acute gastrointestinal ulcers. The results showed that treatment of Int-407 cells with camellia oil (50-75 μg/mL) not only increased the levels of heme oxygenase-1 (HO-1), glutathione peroxidase (GPx), and superoxide dismutase (SOD) mRNA expression but also increased vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2) protein secretion, which served as a mucosal barrier against gastrointestinal oxidative injury. Moreover, Sprague-Dawley (SD) rats treated with camellia oil (2 mL/kg/day) prior to the administration of ketoprofen (50 mg/kg/day) successfully inhibited COX-2 protein expression, inhibited the production of interleukin-6 (IL-6) and nitrite oxide (NO), reversed the impairment of the antioxidant system, and decreased oxidative damage in the gastrointestinal mucosa. More importantly, pretreatment of SD rats with camellia oil strongly inhibited gastrointestinal mucosal injury induced by ketoprofen, which was proved by the histopathological staining of gastrointestinal tissues. Our data suggest that camellia oil exerts potent antiulcer effects against oxidative damage in the stomach and intestine induced by ketoprofen.

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Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress

Cited by 23 publications

References 30 publications

Tricholoma matsutake-Derived Peptides Show Gastroprotective Effects against Ethanol-Induced Acute Gastric Injury

Tricholoma matsutake-Derived Peptides Show Gastroprotective Effects against Ethanol-Induced Acute Gastric Injury

Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs

Beneficial Effects of Camellia Oil (Camellia oleifera Abel.) on Ketoprofen-Induced Gastrointestinal Mucosal Damage through Upregulation of HO-1 and VEGF

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