Intestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota–host co-metabolites and intestinal barrier damage

Yan, Jun; Chen, Qi; Tian, Lei; Li, Kang; Lai, Wenqing; Bian, Liping; Han, Jiahong; Jia, Rui; Liu, Xiaohua; Xi, Zhuge

doi:10.1016/j.scitotenv.2022.153279

Cited by 18 publications

(9 citation statements)

References 140 publications

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“…Disorders of gut microbiota-host co-metabolites are associated with diseases ( Yang et al., 2019 ; Yan et al., 2022 ; Qian et al., 2022 ). Correlation analysis has shown a positive correlation between the pyruvic acid and the severity of ICH.…”

Section: Discussionmentioning

confidence: 99%

Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage

Chen

Wang

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, but effective prevention and treatment strategies are lacking. Recently, gut microbiome and its metabolitesis are considered to be an influencing factor of stroke. However, little is known about the effects of the gut microbiome on ICH and host metabolic activity. Therefore, we used 16S sequencing, macrogenomics sequencing and untargeted metabolomics to explore the differences in gut microbial-metabolome interactions between patients with intracerebral hemorrhage and healthy control populations. We found a significant decrease in the phylum of Firmicutes and a significant increase of Bacteroidetes in ICH patients. At the genus level, Streptococcus, Bifidobacterium, Akkermansia, and Lactobacillus were more abundant in ICH patients. Macrogenomic analysis revealed active glycosaminoglycan degradation, heme synthesis, galactose degradation, lipopolysaccharide core region synthesis, and beta-Lactam resistance in ICH patients. Serum untargeted metabolomic analysis combined with ROC curves showed that octanoylcarnitine, decanoylcarnitine, dodecanoylcarnitine, glyceric acid, pyruvic acid, aspartic acid, methylcysteine, pyroglutamic acid, 9E-tetradecenoic acid, N-Acetylneuraminic acid, and aconitic acid were the best markers for the diagnosis of ICH. Correlation analysis showed that microbiome enriched in the gut of ICH patients were significantly correlated with serum metabolites, revealing a close correlation between the gut microbiome of ICH patients and the host metabolome, and significant differences from the healthy population. microbiota-host co-metabolites including pyruvic acid and 9E-tetradecenoic acid is associated with the the National Institutes of Health Stroke Scale (NIHSS) scores. In conclusion, microbiome-related metabolites in ICH patients was associated with the severity of ICH, the microbiota-host co-metabolites may be a potential may be potential therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage

Chen

Wang

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Several in vivo studies also demonstrated that nano-sized TiO 2 particles exert detrimental effects on the intestinal epithelium layer. As example, increased epithelial permeability leading to impaired barrier function as well as immune damage have been reported after oral exposure of juvenile mice for 28 days to foodborne TiO 2 -NP at doses close to human dietary levels ( 149 ). Whether such changes may impact allergen exposure has been recently addressed in vitro using a co-culture model composed of Caco-2 cell monolayer exposed to allergy sera-primed mast cells.…”

Section: Does Perinatal Exposure To Foodborne Np May Increase the Ris...mentioning

confidence: 99%

Perinatal exposure to foodborne inorganic nanoparticles: A role in the susceptibility to food allergy?

et al. 2022

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“…Dozens of studies have reported that the food hazards intake could induce intestinal barrier dysfunction (Snelson et al., 2021; Chassaing et al., 2022; Yan et al., 2022). Chen et al .…”

Section: Introductionmentioning

confidence: 99%

“…Dozens of studies have reported that the food hazards intake could induce intestinal barrier dysfunction (Snelson et al, 2021;Chassaing et al, 2022;Yan et al, 2022). Chen et al (2019) found that 3-MCPD intake could induce the pathological changes such as villous atrophy and immune infiltration, resulting in intestinal barrier dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Deep‐frying oil intake and risk of intestinal barrier dysfunction: a systematic review and meta‐analyses

Liu

et al. 2023

Int J of Food Sci Tech

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Summary Deep‐frying oil intake is considered to destroy body health. In this review, a meta‐analysis was performed to assess the effects of deep‐frying oil intake on the risk of intestinal barrier dysfunction. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, a systematic literature search was conducted in PubMed, Embase and Cochrane Central updated till April 2022 (CRD42022326306). A total of nine studies were included. The pooled results revealed that deep‐frying oil intake significantly exaggerated crypt damage of colon [weighted mean difference (WMD) = 4.55; 95% CI: 2.87, 6.24, P < 0.05], increased proinflammatory cytokine expression in plasma and colon tissue, and enhanced intestinal permeability [lipopolysaccharides content (WMD: 10.11 μg mL−1, 95% CI: 7.44, 12.79 μg mL−1, P < 0.05)]. Moreover, deep‐frying oil intake could change the gut microbiota and decrease the content of microbiota‐derived short‐chain fatty acids. In conclusion, our findings provide insights into the effect of deep‐frying oil intake on the intestinal barrier dysfunction.

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Intestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota–host co-metabolites and intestinal barrier damage

Cited by 18 publications

References 140 publications

Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage

Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage

Perinatal exposure to foodborne inorganic nanoparticles: A role in the susceptibility to food allergy?

Deep‐frying oil intake and risk of intestinal barrier dysfunction: a systematic review and meta‐analyses

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