Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model

Shi, Lei; Zhang, Binghong; Yu, Honggang; Yu, Jie-Ping; Xi, Juanli

doi:10.1515/jpm.2007.096

Cited by 12 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been previously noted that disordered villi and inflammatory cell infiltration were observed in the duodenum of quail subjected to cold stress [ 27 ]. After hypoxic-ischemic cold stress, Wistar rat pups’ small intestine mucosa showed severe separation of the submucosa from the lamina propria, necrosis, and loss of villi structure [ 28 ]. Muscle edema of the ileum and necrosis of the villi with partial loss of epithelial structures were observable in premature neonatal rats subjected to cold stress and hypoxia [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model

Sun

Song

Zou

et al. 2022

IJMS

View full text Add to dashboard Cite

Endotherms are easily challenged by chronic cold stress. In this study, the development and injury of the small intestine in the Min pig model and Yorkshire pig model under chronic cold stress, and the molecular mechanisms by which glucose supplementation reduces small intestinal mucosal damage were investigated. The results showed that morphological structure lesions of the jejunal mucosa and ileal mucosa were visible in Yorkshire pigs under chronic cold stress. Meanwhile, the Occludin mRNA and protein expression in jejunal mucosa of Yorkshire pigs was decreased. Chronic cold stress enhanced the expression of Toll-like receptor 4 (TLR4), the myeloid differentiation main response 88 (MyD88), nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), cleaved caspase-1, mature-IL-1β, and high-mobility group box 1 (HMGB 1) mRNA and protein expression in jejunal mucosa of Yorkshire pigs, whereas the mRNA and protein of Bax was triggered in ileal mucosa. In Min pigs, no such deleterious consequences were observed. Dietary glucose supplementation ameliorates small intestinal mucosal injury, declined TLR4 and MyD88 expression in jejunal mucosa. In conclusion, chronic cold stress induced the small intestinal mucosa damage in Yorkshire pigs, whereas glucose supplementation mitigated the deleterious effects of chronic cold stress on the small intestine.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model

Sun

Song

Zou

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…roles of pro-inflammatory cytokines in the development of NEC (Seitz et al, 2005), the roles of enterocyte migration in the resolution of NEC (Cetin et al, 2004), and the protective effects of various agents including: maternal cortisol (Israel et al, 1990), intestinal trefoil factor (Guthmann and Kluthe, 2007;Shi et al, 2007), vitamin E (Cadir et al, 2008), captopril (Zani et al, 2008), polyunsaturated fatty acid supplementation , the inhibition of NF-κB (De Plaen et al, 2007), administration of pentoxifylline (Travadi et al, 2006), granulocyte colony stimulating factor (Canpolat et al, 2006), arginine (Shah and Shah, 2007) and anti-TNF-α (Halpern et al, 2006). Taken together, these studies illustrate the important role that the rat model has played in advancing our understanding of NEC pathogenesis and in devising novel therapeutic approaches for this disease.…”

Section: Clinical Puzzlementioning

confidence: 99%

The development of animal models for the study of necrotizing enterocolitis

Sodhi

Richardson

Gribar

et al. 2008

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

Necrotizing enterocolitis (NEC) is the leading cause of death and long-term disability from gastrointestinal disease in preterm infants, and is characterized by acute and chronic intestinal inflammation that may lead to systemic sepsis and multi-system organ failure. NEC typically develops in the preterm infant after the administration of tube feeds, although it may occasionally be seen in full-term babies. Despite extensive clinical experience in the management of patients with NEC, the underlying cellular and molecular mechanisms leading to its development remain incompletely understood. Several animal models have therefore been developed in a variety of species in order to study the pathogenesis of NEC and to develop more effective treatment strategies. This review seeks to examine the pros and cons of animal models that have been developed in the study of NEC over the past 30 years. It will highlight the various strengths and weaknesses of experimental approaches that have been used, and discuss potential directions for the development of such models for the future.

show abstract

“…Trefoil factor 3 (TFF3) is the most abundant in the intestine (65) contributing to the viscoelastic properties of the mucus layer (66) and modulating epithelial healing processes (64). Impaired production of MUC2 and TFF3 has been reported in clinical and experimental NEC (12,67), and intraperitoneal administration of TFF3 reduced NEC-like injury in neonatal rats (59,70).…”

mentioning

confidence: 99%

Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis

Khailová¹,

Dvorak

Arganbright³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

168

159

View full text Add to dashboard Cite

show abstract

Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model

Abstract: ITF may provide a new way for the therapy of NEC in rats.

Cited by 12 publications

References 32 publications

Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model

Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model

The development of animal models for the study of necrotizing enterocolitis

Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis

Contact Info

Product

Resources

About