Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients

Shibagaki, Kotaro; Itawaki, Ayako; Miyaoka, Yoichi; Kishimoto, Kenichi; Takahashi, Yusuke; Kotani, Shunsuke; Mishiro, Tsuyoshi; Oshima, Naoki; Kawashima, Kousaku; Ishimura, Norihisa; Onuma, Hideyuki; Nagasaki, Makoto; Nagase, Mamiko; Araki, Asuka; Kadota, Kyuichi; Kushima, Ryoji; Ishihara, Shunji

doi:10.1007/s00428-021-03237-9

Cited by 9 publications

(11 citation statements)

References 37 publications

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“…Recently, various histological-types of gastric epithelial tumors have been diagnosed in H. pylori-uninfected patients (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The endoscopic features of gastric epithelial tumors in individuals without H. pylori infection are understood by EGD endoscopists (19) and have been frequently reported (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Intestinal-type well-differentiated adenocarcinomas are endoscopically detected in the antrum as depressed lesions with mild surrounding elevation, although these are rarely noted in patients negative for H. pylori (13,14). Pyloric gland type adenomas detected in H. pylori-uninfected subjects are endoscopically detected as elevated lesions in non-atrophic fundic gland areas and those with an immunohistochemically gastric phenotype (15).…”

Section: Methodsmentioning

confidence: 99%

“…Among the various types of gastric epithelial tumors, undifferentiated signet-ring cell carcinoma, gastric adenocarcinoma of fundic-gland type, conventional and raspberry-type gastric foveolar tumors, intestinal-type well-differentiated adenocarcinomas, and pyloric gland type adenomas have been reported in H. pylori-uninfected cases (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). In the present study, hyperplastic polyps were not included as gastric epithelial tumors because endoscopic or surgical treatment for this polyp is usually considered unnecessary.…”

Section: Introductionmentioning

confidence: 95%

“…Helicobacter pylori infection is a well-known risk factor for gastric cancer development, while the occurrence of such cancer is considered rare in H. pylori-uninfected cases (1)(2)(3)(4)(5). However, the development of gastric cancer in H. pyloriuninfected individuals in Japan has recently been frequently reported, and there is an increasing awareness of such cases (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Thus, the detection of gastric cancer in individuals not infected with H. pylori is important for endoscopists who perform esophagogastroduodenoscopy (EGD).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Gastric Epithelial Tumors in <i>Helicobacter pylori</i>-uninfected Individuals Undergoing a Medical Checkup

Okimoto,

Adachi,

Ebisutani

et al. 2024

Intern. Med.

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Objective This study investigated the prevalence of gastric epithelial tumor in Helicobacter pyloriuninfected subjects who underwent esophagogastroduodenoscopy (EGD) as part of an annual checkup. Methods A total of 20,540 EGD examinations of H. pylori-uninfected individuals (12,917 men, 7,623 women; mean age 51.5±9.2 years old) were performed between April 2016 and March 2023. The prevalence of gastric epithelial tumor discovery and the size and location of each lesion type were analyzed. Results According to 20,540 examinations, 61 gastric epithelial tumors were endoscopically and histologically diagnosed in 58 of the subjects, with a prevalence rate of 0.28%. These tumors included signet-ring carcinoma (n=10, 0.05%), gastric adenocarcinoma of fundic-gland type (n=10, 0.05%), intestinal-type welldifferentiated adenocarcinoma (n=2, 0.01%), and raspberry-type gastric foveolar tumors (n=36, 0.18%). One subject had two intestinal-type well-differentiated adenocarcinomas, and two each had two raspberry-type gastric foveolar tumors. The mean sizes of the signet-ring carcinomas, gastric adenocarcinoma of fundicgland type, intestinal-type well-differentiated adenocarcinomas, and raspberry-type gastric foveolar tumors were 6.4, 4.7, 5.0, and 3.4 mm, respectively. Each lesion was located at a specific site in the stomach characteristic of its type. ConclusionIn the present H. pylori-uninfected subjects, the prevalence of gastric epithelial tumors found on an EGD examination was 0.28%. Endoscopic examination should be performed in H. pylori-uninfected individuals to detect such tumors in characteristic locations.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Gastric Epithelial Tumors in <i>Helicobacter pylori</i>-uninfected Individuals Undergoing a Medical Checkup

Okimoto,

Adachi,

Ebisutani

et al. 2024

Intern. Med.

Self Cite

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“…Atrophic gastritis is led by H. pylori infection and has a high risk of gastric cancer (Kato et al, 2019). Although eradication of H. pylori may reduce the risk of gastric cancer in the general population, nevertheless, it does exist and is associated with the degree of atrophy and intestinal metaplasia (Shibagaki et al, 2021). Specific H. pylori antibodies and CagA may act together on the progression of intestinal metaplasia in non-atrophic gastritis (Song et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of different types of Helicobacter pylori: New evidence from non-amplified white light endoscopy

Liu

Kong²,

Hui³

et al. 2023

Front. Microbiol.

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BackgroundDifferent types of Helicobacter pylori (H. pylori) were analyzed to determine their infection characteristics using serology, pathology, and non-magnification white light endoscopy combined with the Kimura–Takemoto classification, and the regular arrangement of collecting venules (RAC) as well.Materials and methodsA retrospective analysis of 685 inpatients who have completed the 14C-urea breath test, the H. pylori antibody typing classification, the serum gastric function tests (PGI/PGII/G-17), the endoscope detection, and the pathological examinations.ResultsThe levels of PGI, PGII, and G-17 were in descending order from the type I H. pylori infection group to the type II H. pylori infection group than the control group (F = 14.31; 26.23; 9.12, P < 0.01). Using the Kimura–Takemoto classification, there were significant differences among the three groups of different degrees of atrophy (χ2=29.81; 482.78; 292.5, P< 0.01). Based on the characteristics of RAC, the H. pylori infection rates were in descending order from the type I H. pylori infection group to the type II H. pylori infection group than the control group (χ2= 200.39; 174.72; 143.51, P < 0.01). The type I H. pylori infection group had higher grades than those of the type II H. pylori infection group in the OLGA and OLGIM staging systems, while the differences are statistically significant only in the OLGA staging system (χ2=10.63, P < 0.05).ConclusionWith the aid of non-amplified white light endoscopy, we found new evidence of type I H. pylori infection accelerating the progression of gastric mucosal atrophy through the degree of atrophy and the range of infection, whereas type II H. pylori infection has a low ability of migration and atrophy progression. Individual virulence factor-based eradication therapy may be a better choice in future.

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Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -naïve patients: a multicenter retrospective analysis

Kotani,

Shibagaki,

Hirahara

et al. 2023

J Gastroenterol

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Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients

Cited by 9 publications

References 37 publications

Prevalence of Gastric Epithelial Tumors in <i>Helicobacter pylori</i>-uninfected Individuals Undergoing a Medical Checkup

Prevalence of Gastric Epithelial Tumors in <i>Helicobacter pylori</i>-uninfected Individuals Undergoing a Medical Checkup

Characteristics of different types of Helicobacter pylori: New evidence from non-amplified white light endoscopy

Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -naïve patients: a multicenter retrospective analysis

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