Intestine-Specific Ablation of Mouse atonal homolog 1 (Math1) Reveals a Role in Cellular Homeostasis

Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling

“…This is a malignant human colon carcinoma cell line that differentiates, upon contact inhibition of cell growth, into normal-appearing polarized goblet cells that synthesize and secrete colonspecific mucin (Augeron and Laboisse, 1984;Augenlicht et al, 1987;Laburthe et al, 1989;Merlin et al, 1994). Since transition between these states seems to recapitulate the normal growth arrest and lineage-specific differentiation of colonic progenitor cells that is mediated by reduction of Notch signaling in the intestine (Yang et al, 2001;Shroyer et al, 2007), we focused on this cell line to investigate the potential role of Notch signaling in general, and Jagged1 specifically, in regulating Notch signaling in the colon carcinoma cell phenotype.…”

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis

“…Rosa-YFP (Srinivas et al, 2001) and K15-CREPR mice (Morris et al, 2004) were obtained from The Jackson Laboratory. Atoh1 flox/flox mice (Shroyer et al, 2007) were obtained from H.Y. Zoghbi (Baylor College of Medicine, Houston, TX).…”

“…Conditional deletion of Atoh1 in all cells of the developing trunk region using Hoxb1-CRE resulted in the absence of MC specification in the paw and the back skin epidermis, but MCs of the whisker region were still present (Maricich et al, 2009). To determine whether Atoh1 expression in epidermal progenitors and their progeny is required for MC specification in all body locations, including the whisker region, we deleted the floxed alleles of the Atoh1/Math1 gene (Shroyer et al, 2007) in the developing skin epidermis using K14-CRE mice (Vasioukhin et al, 2001). Mice deficient for Atoh1 in the skin epidermis (Atoh1 conditional knockout [cKO]) were born alive at a Mendelian ratio and were macroscopically indistinguishable from control mice (Fig.…”

Stox1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation

“…29,[42][43][44][45] Although Math1 appears to bind to the E-box of the DNA promoter regions of specific genes by a competition …”