Inteurleukin-8 gene variations and the susceptibility to schizophrenia

Afia, Amira Ben; Aflouk, Youssef; Saoud, Hana; Zaâfrane, F.; Gaha, L.; Jrad, Besma Bel Hadj

doi:10.1016/j.psychres.2020.113421

Cited by 10 publications

(9 citation statements)

References 91 publications

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“…In addition, the rs1126647 SNP appears to predispose more particularly females to the paranoid form. The rare haplotypes TTT, ACT, and TCT haplotypes at rs4073-rs2227306-rs1126647, each comprising the risk allele rs1126647T, were related to the higher risk of paranoid schizophrenia, whereas only the TCT arrangement constitutes a risk factor for general schizophrenia (127).…”

Section: Cytokine Polymorphisms In Schizophreniamentioning

confidence: 94%

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

2021

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Cytokines are one of the most important components of the immune system. They orchestrate the brain's response to infectious and other exogenous insults and are crucial mediators of the cross-talk between the nervous and immune systems. Epidemiological studies have demonstrated that severe infections and autoimmune disorders, in addition to genetic predisposition, are risk factors for schizophrenia. Furthermore, maternal infection during pregnancy appears to increase the risk of schizophrenia, and proinflammatory cytokines may be negatively involved in the neurodevelopmental process. A cytokine imbalance has been described in the blood and cerebrospinal fluid of schizophrenia patients, particularly in the T helper type 1 [Th1] and type 2 [Th2] cytokines, albeit the results of such studies appear to be contradictory. Chronic stress, likewise, appears to contribute to a lasting proinflammatory state and likely also promotes the disorder. The aim of this mini-review is to investigate the roles of different cytokines in the pathophysiology of schizophrenia and define how cytokines may represent key molecular targets to regulate for the prevention and treatment of schizophrenia. How current antipsychotic drugs impact cytokine networks is also evaluated. In this context, we propose to change the focus of schizophrenia from a traditionally defined brain disorder, to one that is substantially impacted by the periphery and immune system.

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Section: Cytokine Polymorphisms In Schizophreniamentioning

confidence: 94%

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

2021

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“…using the DSM-IV and ICD-10 criteria showed a high rate of paranoid form and a low rate for hebephrenic and catatonic forms in the Austria population of Vienna [ 38 ]. On the other hand, undifferentiated forms were very frequent in the Tunisian population followed by Paranoid forms [ 39 ]. The first-born siblings were the most affected by schizophrenia in our study (31.1% of cases).…”

Section: Discussionmentioning

confidence: 99%

Descriptive study of cases of schizophrenia in the Malian population

Mounkoro

Diakité

et al. 2021

BMC Psychiatry

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Background Schizophrenia is a relatively common disease worldwide with a point prevalence of around 5/1000 in the population. The aim of this present work was to assess the demographic, clinical, familial, and environmental factors associated with schizophrenia in Mali. Methods This was a prospective descriptive study on a series of 164 patients aged at least 12 years who came for a follow-up consultation at the psychiatry department of the University Hospital Center (CHU) Point G in Mali between February 2019 and January 2020 for schizophrenia spectrum disorder as defined by DSM-5 diagnostic criteria. Results Our results revealed that the male sex was predominant (80.5%). The 25–34 age group was more represented with 44.5%. The place of birth for the majority of our patients was the urban area (52.4%), which also represented the place of the first year of life for the majority of our patients (56.1%). We noted that the unemployed and single people accounted for 56.1 and 61% respectively. More than half of our patients 58.5% reported having reached secondary school level. With the exception of education level, there was a statistically significant difference in the distribution of demographic parameters. Familial schizophrenia cases accounted for 51.7% versus 49.3% for non-familial cases. The different clinical forms were represented by the paranoid form, followed by the undifferentiated form, and the hebephrenic form with respectively 34, 28 and 17.1%. We noted that almost half (48.8%) of patients were born during the cold season. Cannabis use history was not observed in 68.7% of the patients. The proportions of patients with an out-of-school father or an out-of-school mother were 51.2 and 64.2%, respectively. Conclusion The onset of schizophrenia in the Malian population has been associated with socio-demographic, clinical, genetic and environmental characteristics.

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“…Notably, females displayed a significant association between the rs1126647 T allele and the T/T genotype, correlating with an elevated risk of paranoid schizophrenia. In males, this predisposition was observed specifically in those carrying the rs1126647 T/T genotype [186]. Moreover, the presence of the rs1126647 T allele and T/T genotype in paranoid schizophrenia was significantly associated with an adult-onset age of 24 years and older.…”

Section: Cxcl8 Gene and Snpsmentioning

confidence: 93%

“…The CXCL8 gene is located on chromosome 4q13-21 and comprises four exons and three introns, featuring a unique CAT-and TATA-like structure [113,185,186]. The proximal segment of the CXCL8 promoter includes around 200 nucleotides within the 5 ′ -flanking region of the CXCL8 gene, playing a significant role in regulating the transcription of this gene [187].…”

Section: Cxcl8 Gene and Snpsmentioning

confidence: 99%

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Shkundin,

Halaris

2024

JPM

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Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation and disease progression. Additionally, CXCL8 gene polymorphisms can alter IL-8 production, leading to potential differences in disease susceptibility, progression, and severity across populations. IL-8 levels vary among neuropsychiatric conditions, demonstrating sensitivity to psychosocial stressors and disease severity. IL-8 can be detected in blood circulation, cerebrospinal fluid (CSF), and urine, making it a promising candidate for a broad-spectrum biomarker. This review highlights the need for further research on the diverse effects of IL-8 and the associated implications for personalized medicine. A thorough understanding of its complex role could lead to the development of more effective and personalized treatment strategies for neuropsychiatric conditions.

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Inteurleukin-8 gene variations and the susceptibility to schizophrenia

Cited by 10 publications

References 91 publications

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

Descriptive study of cases of schizophrenia in the Malian population

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

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