Intima-media thickness of common femoral vein is increased in Behçet's disease

Sevik, Gizem; Ergelen, Rabia; Ağaçkiran, S. Kutluğ; Direşkeneli, Haner; Alıbaz-Öner, Fatma

doi:10.1016/j.clim.2023.109306

Cited by 5 publications

(9 citation statements)

References 21 publications

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“…Similar to other studies in which the VWT was measured in BD ( Supplementary Table S1 ), we found that the VWT of the CFV was significantly higher in the BD group than in the other study groups. While the WWT of the mean right CFV of BD patients in the present study was 0.68 ± 0.12 mm, it was found to be between 0.68–0.92 mm in other studies [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. In the present study, the WWT of the CFV had an advantage in 79.8% sensitivity and 64.7% specificity at a cutoff value of 0.58 mm.…”

Section: Discussioncontrasting

confidence: 77%

“…Notably, in a previous study, there was no significant increase in the CIMT and femoral artery IMT in cases of BD [ 30 ]. Inflammation, which is thought to be the cause of increased wall thickness in vessels, is more prominent in veins than in arteries in BD cases [ 17 ]. Moreover, in cases presenting BD compared with arterial involvement, venous involvement affects the intimal layer and may cause significant changes in the vessel wall [ 17 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation, which is thought to be the cause of increased wall thickness in vessels, is more prominent in veins than in arteries in BD cases [ 17 ]. Moreover, in cases presenting BD compared with arterial involvement, venous involvement affects the intimal layer and may cause significant changes in the vessel wall [ 17 , 31 ]. However, information regarding the histopathology of the venous involvement in BD is limited.…”

Section: Discussionmentioning

confidence: 99%

“…In cases of BD, although there is no histological evidence, it has been reported that venous inflammation, which may cause endothelial dysfunction and a thrombosis tendency, may increase the venous wall thickness [ 10 ]. However, it is currently unknown whether venous inflammation is mainly mediated by vasa vasorum affecting the adventitia, as in arterial disease, or by endothelial inflammation causing intimal thickening [ 17 ]. In the relevant literature, the number of studies evaluating the venous IMT is limited.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these findings, it has been suggested that the measurement of the common femoral vein (CFV) thickness can be a valuable, practical, and cost-effective diagnostic tool for diagnosing BD [ 9 ]. Furthermore, it has been reported that the thickening of the intima–media of the CFV may occur in patients with BD in addition to increased VWT [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet’s Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis

Erturk,

Sarıkaya,

Coşkun

et al. 2023

Diagnostics

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Recurrent oral ulcers, which are the first and most common manifestation of Behçet’s disease (BD), have several etiological causes but are often idiopathic and known as recurrent aphthous stomatitis (RAS). In recent years, publications have drawn attention to the fact that whole-wall thickness (WWT) and intima–media thickness (IMT) measurements of the common femoral vein (CFV) may be useful in the diagnosis of BD, which are independent of organ involvement. In this study, the usefulness of the WWT and IMT of the CFV measured by venous Doppler ultrasound (US) was investigated in differentiating BD presenting with oral ulcers from RAS. Patients with BD (n = 84), patients with RAS (n = 85), and healthy controls (HCs) (n = 70) were the three groups included. Both the right and left WWT of the CFV were significantly higher in the BD compared with the HCs and RAS groups (p < 0.001). The diagnostic cutoff values of ≥0.58 mm for the WWT of the CFV performed well against both the patients with RAS and HCs for the discrimination of BD (sensitivity = 79.8%, specificity = 64.7%). In patients with recurrent oral ulcers, the WWT of the CFV measurement may be a distinctive new diagnostic tool for the differential diagnosis of BD and RAS.

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