2002
DOI: 10.1016/s1053-2498(02)00464-3
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Intimal hyperplasia and coronary flow reserve after heart transplantation: association with big endothelin-1

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Cited by 10 publications
(7 citation statements)
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“…15 Thus, the decrease in plasma ET-1 levels elicited by Tac may help maintain eNOS levels and the related protective effects of NO. This result has important implications, as increased ET-1 levels were associated with progression of intimal hyperplasia post-transplant, 16 whereas decreasing levels with ET-1 blockade attenuated AV development in rodent cardiac allograft models. 17 Oxidative stress is a well-known contributor to endothelial dysfunction.…”
Section: Discussionmentioning
confidence: 94%
“…15 Thus, the decrease in plasma ET-1 levels elicited by Tac may help maintain eNOS levels and the related protective effects of NO. This result has important implications, as increased ET-1 levels were associated with progression of intimal hyperplasia post-transplant, 16 whereas decreasing levels with ET-1 blockade attenuated AV development in rodent cardiac allograft models. 17 Oxidative stress is a well-known contributor to endothelial dysfunction.…”
Section: Discussionmentioning
confidence: 94%
“…Namely, while the stimulated endothelin system has gained special prognostic interest, the value of measuring plasma BET levels in patients with advanced disease left ventricular ejection fraction (LVEF) <20% is well established. Therefore, BET-1 assessment will be used for determination of doxorubicine-CHF and estimation of subsequent deterioration (4,7,17,18).…”
Section: Introductionmentioning
confidence: 99%
“…30,31 Wexberg and colleagues reported the relationship between intimal hyperplasia as a chronic rejection and big endothelin-1. 32 Our study suggests that using endothelin receptor antagonist before heart transplantation can prevent transplant vasculopathy and graft failure.…”
Section: Discussionmentioning
confidence: 72%