Intimate cell contacts at the epithelial/mesenchymal interface in embryonic mouse lung

Bluemink, John G.; Maurik, P. van; Lawson, Kirstie A.

doi:10.1016/s0022-5320(76)80071-8

Cited by 121 publications

(45 citation statements)

References 37 publications

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“…46 These contacts are transient in nature and are only observed between the epithelial cells in the end-buds of the initial 4 to 12 branches of the early rudiment and the dense capsular mesenchyme surrounding these endbuds. 58 - 59 Similar contacts have been described in the developing kidney, 61 lung, 62 and tooth buds. 63 Data from in vitro transfilter studies 1722 - 23 -33 supported a role for diffusible extracellular matrix molecules in the induction and maintenance of salivary gland morphogenesis.…”

supporting

confidence: 65%

Epithelial-Mesenchymal Interactions in the Development of Salivary Glands

Cutler

Gremski

1991

Critical Reviews in Oral Biology & Medicine

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The full expression of both morphogenesis and secretory cell differentiation in salivary glands is modulated or controlled, at least in part, by interactions between the salivary epithelium and the surrounding mesenchyme. Salivary gland morphogenesis and cytodifferentiation are partially linked but independently regulated processes. This presentation reviews the information that establishes the role of various extracellular matrix molecules and direct epithelial-mesenchymal interactions in the induction, control, and maintenance of morphogenesis and secretory cell differentiation in salivary glands.

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supporting

confidence: 65%

Epithelial-Mesenchymal Interactions in the Development of Salivary Glands

Cutler

Gremski

1991

Critical Reviews in Oral Biology & Medicine

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“…In addition to the role of epithelial-interstitial connections in leukocyte migration, transbasal lamina epithelial/interstitial connections seem to play some role in the development, maintenance, and repair in lung and other tissues (24)(25)(26)(27)(28)(29). These contacts have been implicated in the epithelial/mesenchymal communication necessary for the embryonic development of tissues (30)(31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Alteration of Fibroblast Architecture and Loss of Basal Lamina Apertures in Human Emphysematous Lung

Sirianni¹,

Milaninezhad²,

Chu³

et al. 2006

Am J Respir Crit Care Med

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Rationale:In normal human lung, single alveolar fibroblasts link capillary endothelium to type 2 pneumocytes through apertures in the endothelial and epithelial basal laminae. These fibroblasts are hypothesized to play a role in cellular communication between the endothelium and epithelium and are positioned to provide leukocytes a surface on which they may migrate through the interstitium. Objectives: To determine whether fibroblasts link the endothelium to the epithelium in emphysematous lung and to compare basal lamina aperture frequency with previously published results. Methods: We performed transmission electron microscopy serial section three-dimensional reconstructions of emphysematous regions of human alveolar wall and a quantitative analysis of basal lamina apertures beneath 403 type 2 pneumocytes. Measurements and Main Results: Our three-dimensional reconstruction demonstrated that the fibroblasts subtending type 2 pneumocytes in emphysematous lung no longer link these epithelial cells to the capillary endothelium through basal lamina apertures. Basal lamina apertures may be absent below some type 2 pneumocytes. Our morphometric analysis showed that their frequency and area beneath type 2 pneumocytes is significantly reduced in emphysematous regions when compared with nonemphysematous regions of matched control lung. Conclusions: We conclude that the endothelial/fibroblast/epithelial linkage is disrupted in emphysematous human lungs and postulate this disruption may disturb leukocyte migration and account for their accumulation in the alveolar interstitium of emphysematous lung tissue.

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“…The connective tissue in this region, associated with the tunica adventitia of the vessel wall, was more fibrous and probably contained more fibroblasts than the connective tissue associated with the distal lung. The role of the extracellular matrix in modification of epithelial cell development is well documented in the lungs of rats and mice-animals whose lungs contain no respiratory bronchiole (Bluemink et al, 1976;Masters, 1976;Smith and Fletcher, 1979;Des Biens, 1974, 1975). Des Biens (1974, 1975) describe the influence on epithelial development of the myoblast and fibroblast under the bronchial, primitive respiratory bronchiolar, and the alveolar regions.…”

Section: Discussionmentioning

confidence: 99%

Morphogenesis of the respiratory bronchiole in rhesus monkey lungs

et al. 1988

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The epithelium of the respiratory bronchiole in the adult rhesus monkey consists of two populations: a pseudostratified epithelium with basal, mucous goblet, and ciliated cells located near the pulmonary artery (PA); and a simple cuboidal epithelium composed only of nonciliated bronchiolar epithelial (or Clara) cells in areas away from the PA. This study describes the pattern of differentiation of these two epithelial populations, and their relationship to the PA and to the time of appearance of alveoli in the respiratory bronchiole of the rhesus monkey during the period of 90-125 days gestational age (DGA). These events were related to changes in the adjacent parenchyma. Dissected airways of infusion-fixed, critical-point-dried lungs were evaluated by scanning microscopy followed by light microscopy of the same airways. At 54% of gestation (90 DGA), the distal airway was lined by a mixture of ciliated and nonciliated cells. By 67% of gestation (110 DGA), the ciliated cells were confined to the epithelium over the PA. The underlying connective tissue initially was cellular containing few fibers but was fibrous by 76% of gestation (125 DGA). Alveolarization began near the most distal cartilage at 57% of gestation (95 DGA), the same period at which secondary septation occurred in the distal acinus. Thus, alveolarization occurred simultaneously in two centers: 1) the proximal centriacinar region in the vicinity of the most distal cartilage and 2) the distal lung parenchyma. The duration of centriacinar alveolarization was short, approximately 5 days.

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Intimate cell contacts at the epithelial/mesenchymal interface in embryonic mouse lung

Cited by 121 publications

References 37 publications

Epithelial-Mesenchymal Interactions in the Development of Salivary Glands

Epithelial-Mesenchymal Interactions in the Development of Salivary Glands

Alteration of Fibroblast Architecture and Loss of Basal Lamina Apertures in Human Emphysematous Lung

Morphogenesis of the respiratory bronchiole in rhesus monkey lungs

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